CPPs-modified chitosan as permeability-enhancing chemotherapeutic combined with gene therapy nanosystem by thermosensitive hydrogel for the treatment of osteosarcoma

Chemotherapy resistance of osteosarcoma (OS) is still the crux of poor clinical curative effect.E3 ubiquitin-protein ligase Rad18 (Rad18) contributed to doxorubicin resistance in OS, which ultimately mediated DNA damage tolerance and led to a poor prognosis and chemotherapy response in patients. In...

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Veröffentlicht in:	International journal of biological macromolecules 2024-05, Vol.267 (Pt 2), p.130915-130915, Article 130915
Hauptverfasser:	Cao, Jie, Zhu, Chenghong, Cao, Ziqi, Ke, Xue
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bone Neoplasms - drug therapy Bone Neoplasms - genetics Bone Neoplasms - pathology Bone Neoplasms - therapy cell death Cell Line, Tumor Cell penetrating peptide Cell-Penetrating Peptides - chemistry Cell-Penetrating Peptides - pharmacology Chemotherapy resistance chitosan Chitosan - chemistry DNA damage Doxorubicin Doxorubicin - chemistry Doxorubicin - pharmacology drug delivery systems drug therapy encapsulation gene therapy Genetic Therapy - methods Humans hydrogels Hydrogels - chemistry immune system Immunogenic cell death immunotherapy lungs metastasis Mice nanoparticles Nanoparticles - chemistry Osteosarcoma Osteosarcoma - drug therapy Osteosarcoma - genetics Osteosarcoma - pathology peptides Permeability prognosis siRad18 Temperature thermosensitivity ubiquitin-protein ligase
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