Life-time exposure to decabromodiphenyl ethane (DBDPE) caused transgenerational epigenetic alterations of thyroid endocrine system in zebrafish

Because of its ubiquitous occurrence in the environment, decabromodiphenyl ethane (DBDPE), a novel brominated flame retardant, has been widely concerned. However, its transgenerational thyroid disrupting potential and intricate mechanism are barely explored. Therefore, zebrafish embryos were exposed...

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Veröffentlicht in:	The Science of the total environment 2024-11, Vol.950, p.175337, Article 175337
Hauptverfasser:	Sun, Yumiao, Wang, Xiaochen, Guo, Wei, Li, Fan, Hua, Jianghuan, Zhu, Biran, Guo, Yongyong, Han, Jian, Yang, Lihua, Zhou, Bingsheng
Format:	Artikel
Sprache:	eng
Schlagworte:	adults chronic exposure Danio rerio Decabromodiphenyl ethane DNA methylation endocrine system environment epigenetics flame retardants Neurotoxicity progeny promoter regions sexual maturity Thyroid disruption thyroid hormones toxicity transcription (genetics) Transgenerational toxicity
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