The role of HMGB1 on SiC NPs-induced inflammation response in lung epithelial-macrophage co-culture system

In recent years, carbonized silicon nanoparticles (SiC NPs) have found widespread scientific and engineering applications, raising concerns about potential human health risks. SiC NPs may induce pulmonary damage through sustained inflammatory responses and oxidative stress, with unclear toxicity mec...

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Veröffentlicht in:	Food and chemical toxicology 2024-08, Vol.190, p.114762, Article 114762
Hauptverfasser:	Chen, Xiao, Zhang, Linyuan, Yu, Changyan, Duan, Airu, Jiao, Bo, Chen, Yuanyuan, Dai, Yufei, li, Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	advanced glycation end products AM-AT II co-culture coculture cytokines cytotoxicity epithelium High mobility group box 1 (HMGB1) human health inflammation Inflammatory lungs macrophages nanoparticles nucleoproteins oxidative stress silicon Silicon carbide nanoparticles (SiC NPs) TLR4–RAGE crosstalk Toll-like receptor 4
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