Methylation Levels in the 5' Region of the TBX20 Gene in the Ascending Aorta Change in Opposite Direction in Atherosclerosis and Aneurysm
We found hypomethylation of five CpG sites in the 5' region of TBX20 gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262...
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| Veröffentlicht in: | Russian journal of genetics 2024-07, Vol.60 (7), p.977-981 |
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| container_title | Russian journal of genetics |
| container_volume | 60 |
| creator | Koroleva, Iu. A. Goncharova, I. A. Zarubin, A. A. Shipulina, S. A. Sleptsov, A. A. Panfilov, D. S. Kozlov, B. N. Nazarenko, M. S. |
| description | We found hypomethylation of five CpG sites in the 5' region of
TBX20
gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262250 region changes in opposite direction in aortic dissection and aortic atherosclerosis. The results suggest an alteration in epigenetic regulation both in aortic atherosclerosis and aortic aneurysm. |
| doi_str_mv | 10.1134/S102279542470042X |
| format | Article |
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TBX20
gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262250 region changes in opposite direction in aortic dissection and aortic atherosclerosis. The results suggest an alteration in epigenetic regulation both in aortic atherosclerosis and aortic aneurysm.</description><identifier>ISSN: 1022-7954</identifier><identifier>EISSN: 1608-3369</identifier><identifier>DOI: 10.1134/S102279542470042X</identifier><language>eng</language><publisher>Moscow: Pleiades Publishing</publisher><subject>aneurysm ; Animal Genetics and Genomics ; aorta ; atherosclerosis ; Biomedical and Life Sciences ; Biomedicine ; dissection ; DNA methylation ; epigenetics ; genes ; Human Genetics ; Microbial Genetics and Genomics ; Short Communications</subject><ispartof>Russian journal of genetics, 2024-07, Vol.60 (7), p.977-981</ispartof><rights>Pleiades Publishing, Inc. 2024. ISSN 1022-7954, Russian Journal of Genetics, 2024, Vol. 60, No. 7, pp. 977–981. © Pleiades Publishing, Inc., 2024.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c203t-63f9f20708a3b4e466fa090ec76957fc299595ccb3c299ed36317684c97f26e93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1134/S102279542470042X$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1134/S102279542470042X$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids></links><search><creatorcontrib>Koroleva, Iu. A.</creatorcontrib><creatorcontrib>Goncharova, I. A.</creatorcontrib><creatorcontrib>Zarubin, A. A.</creatorcontrib><creatorcontrib>Shipulina, S. A.</creatorcontrib><creatorcontrib>Sleptsov, A. A.</creatorcontrib><creatorcontrib>Panfilov, D. S.</creatorcontrib><creatorcontrib>Kozlov, B. N.</creatorcontrib><creatorcontrib>Nazarenko, M. S.</creatorcontrib><title>Methylation Levels in the 5' Region of the TBX20 Gene in the Ascending Aorta Change in Opposite Direction in Atherosclerosis and Aneurysm</title><title>Russian journal of genetics</title><addtitle>Russ J Genet</addtitle><description>We found hypomethylation of five CpG sites in the 5' region of
TBX20
gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262250 region changes in opposite direction in aortic dissection and aortic atherosclerosis. The results suggest an alteration in epigenetic regulation both in aortic atherosclerosis and aortic aneurysm.</description><subject>aneurysm</subject><subject>Animal Genetics and Genomics</subject><subject>aorta</subject><subject>atherosclerosis</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>dissection</subject><subject>DNA methylation</subject><subject>epigenetics</subject><subject>genes</subject><subject>Human Genetics</subject><subject>Microbial Genetics and Genomics</subject><subject>Short Communications</subject><issn>1022-7954</issn><issn>1608-3369</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9UM1OwzAMrhBIjMEDcMsNLgUnadPmWAYMpKFJMKTdqixzt05dWpIWaY_AW5NucELiYlvfj2V_QXBJ4YZSHt2-UWAskXHEogQgYvOjYEAFpCHnQh772dNhz58GZ85tACiA4IPg6wXb9a5SbVkbMsFPrBwpDWnXSOIr8oqrHq-LPTC7mzMgYzT4K8mcRrMszYpktW0VGa2VWe3ZadPUrmyR3JcW9X67RzNvsrXTVV9LR5RZksxgZ3duex6cFKpyePHTh8H748Ns9BROpuPnUTYJNQPehoIXsmCQQKr4IsJIiEKBBNSJkHFSaCZlLGOtF7wfcckFp4lIIy2TggmUfBhcH_Y2tv7o0LX5tvRvVJUyWHcu5zTmCXCegpfSg1T7c53FIm9suVV2l1PI-9jzP7F7Dzt4nNf6MGy-qTtr_Ef_mL4BU_eDrA</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Koroleva, Iu. A.</creator><creator>Goncharova, I. A.</creator><creator>Zarubin, A. A.</creator><creator>Shipulina, S. A.</creator><creator>Sleptsov, A. A.</creator><creator>Panfilov, D. S.</creator><creator>Kozlov, B. N.</creator><creator>Nazarenko, M. S.</creator><general>Pleiades Publishing</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240701</creationdate><title>Methylation Levels in the 5' Region of the TBX20 Gene in the Ascending Aorta Change in Opposite Direction in Atherosclerosis and Aneurysm</title><author>Koroleva, Iu. A. ; Goncharova, I. A. ; Zarubin, A. A. ; Shipulina, S. A. ; Sleptsov, A. A. ; Panfilov, D. S. ; Kozlov, B. N. ; Nazarenko, M. S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c203t-63f9f20708a3b4e466fa090ec76957fc299595ccb3c299ed36317684c97f26e93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>aneurysm</topic><topic>Animal Genetics and Genomics</topic><topic>aorta</topic><topic>atherosclerosis</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>dissection</topic><topic>DNA methylation</topic><topic>epigenetics</topic><topic>genes</topic><topic>Human Genetics</topic><topic>Microbial Genetics and Genomics</topic><topic>Short Communications</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Koroleva, Iu. A.</creatorcontrib><creatorcontrib>Goncharova, I. A.</creatorcontrib><creatorcontrib>Zarubin, A. A.</creatorcontrib><creatorcontrib>Shipulina, S. A.</creatorcontrib><creatorcontrib>Sleptsov, A. A.</creatorcontrib><creatorcontrib>Panfilov, D. S.</creatorcontrib><creatorcontrib>Kozlov, B. N.</creatorcontrib><creatorcontrib>Nazarenko, M. S.</creatorcontrib><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Russian journal of genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Koroleva, Iu. A.</au><au>Goncharova, I. A.</au><au>Zarubin, A. A.</au><au>Shipulina, S. A.</au><au>Sleptsov, A. A.</au><au>Panfilov, D. S.</au><au>Kozlov, B. N.</au><au>Nazarenko, M. S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Methylation Levels in the 5' Region of the TBX20 Gene in the Ascending Aorta Change in Opposite Direction in Atherosclerosis and Aneurysm</atitle><jtitle>Russian journal of genetics</jtitle><stitle>Russ J Genet</stitle><date>2024-07-01</date><risdate>2024</risdate><volume>60</volume><issue>7</issue><spage>977</spage><epage>981</epage><pages>977-981</pages><issn>1022-7954</issn><eissn>1608-3369</eissn><abstract>We found hypomethylation of five CpG sites in the 5' region of
TBX20
gene (7p14.2) in the tissues of atherosclerotic aortic plaque compared to dilated part of aorta in patients with ascending aortic aneurysm. Using GEO database, we found that the DNA methylation level in the chr7:35253926-35262250 region changes in opposite direction in aortic dissection and aortic atherosclerosis. The results suggest an alteration in epigenetic regulation both in aortic atherosclerosis and aortic aneurysm.</abstract><cop>Moscow</cop><pub>Pleiades Publishing</pub><doi>10.1134/S102279542470042X</doi><tpages>5</tpages></addata></record> |
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| subjects | aneurysm Animal Genetics and Genomics aorta atherosclerosis Biomedical and Life Sciences Biomedicine dissection DNA methylation epigenetics genes Human Genetics Microbial Genetics and Genomics Short Communications |
| title | Methylation Levels in the 5' Region of the TBX20 Gene in the Ascending Aorta Change in Opposite Direction in Atherosclerosis and Aneurysm |
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