Endogenous Protein–Protein Interaction Network of the NPC Cholesterol Transporter 1 in the Cerebral Cortex

NPC intracellular cholesterol transporter 1 (NPC1) is a multipass, transmembrane glycoprotein mostly recognized for its key role in facilitating cholesterol efflux. Mutations in the NPC1 gene result in Niemann-Pick disease, type C (NPC), a fatal, lysosomal storage disease. Due to the progressively e...

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Veröffentlicht in:	Journal of proteome research 2024-08, Vol.23 (8), p.3174-3187
Hauptverfasser:	Javanshad, Roshan, Nguyen, Thu T. A., Azaria, Ruth D., Li, Wenping, Edmison, Daisy, Gong, Liang-Wei, Gowrishankar, Swetha, Lieberman, Andrew P., Schultz, Mark L., Cologna, Stephanie M.
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Animals cerebral cortex Cerebral Cortex - metabolism cholesterol Cholesterol - metabolism cortex cytoskeleton genes glycoproteins Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Mice Mice, Knockout mutants Mutation neurons Neurons - metabolism Niemann-Pick C1 Protein Niemann-Pick Disease, Type C - genetics Niemann-Pick Disease, Type C - metabolism Protein Interaction Maps protein-protein interactions proteome proteomics Proteomics - methods species synaptic vesicles
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