Effects of chronic Cr and Ni co-exposure on liver inflammation and autophagy in mice by regulating the TLR4/mTOR pathway

Exposure to Cr and/or Ni can have widespread implications on the environment and health. However, the specific toxic effects of chronic Cr and Ni co-exposure on mice liver have not been reported. To ascertain the combined toxic effects of chronic Cr and Ni co-exposure on liver damage in mice, 80 6-w...

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Veröffentlicht in:	The Science of the total environment 2024-05, Vol.926, p.171921-171921, Article 171921
Hauptverfasser:	Cao, Xianhong, Zheng, Shuangyan, Zeng, Yizhou, Shi, Yan, Du, Jun, Huang, Cheng, Shen, Yufan, Liu, Ping, Guo, Xiaoquan, Gao, Xiaona
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy Chromium environment factor analysis Female females gene expression histology inflammation Inflammation - chemically induced interleukin-6 Interleukin-6 - metabolism liver Liver - metabolism Liver toxic effect Mice Mice, Inbred C57BL Myeloid Differentiation Factor 88 - metabolism NF-kappa B Nickel protein synthesis RNA, Messenger Signal Transduction TLR4/mTOR pathway TNF Receptor-Associated Factor 6 - metabolism TNF Receptor-Associated Factor 6 - pharmacology Toll-Like Receptor 4 - metabolism TOR Serine-Threonine Kinases - metabolism TOR Serine-Threonine Kinases - pharmacology toxicity Tumor Necrosis Factor-alpha - metabolism
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