The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis
Visceral leishmaniasis (VL) occurs due to the evolution, virulence, and adaptation of Leishmania , vector biology, host immune system evasion, and reservoir hosts. Parasitemia can be involved as a warning regarding the clinical severity of VL The present study aims to evaluate the relationship betwe...
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| Veröffentlicht in: | Indian journal of microbiology 2024-06, Vol.64 (2), p.511-519 |
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| creator | Campelo, Cássio Marinho Medvedovsky, Andres Christopher de Holanda, Pablo Eliak Linhares de Oliveira, Denis Francisco Gonçalves de Albuquerque-Pinto, Luiz Carlos Melo, Luciana Magalhães Câmara, Lilia Maria Carneiro |
| description | Visceral leishmaniasis (VL) occurs due to the evolution, virulence, and adaptation of
Leishmania
, vector biology, host immune system evasion, and reservoir hosts. Parasitemia can be involved as a warning regarding the clinical severity of VL The present study aims to evaluate the relationship between parasitemia and the prognosis of individuals with VL. Blood and bone marrow samples from individuals with VL were analyzed to identify parasite and quantify or measure parasite burden. Individuals were classified in the clinical score model of risk of death by disease proposed by Coura-Vital et al. (PLoS Negl Trop Dis 8(12): e33742014, 2014). 39/74 individuals presented a better prognosis, and 35/74 individuals presented a worse prognosis. HIV + VL co-infection was present in 32 individuals, of which 12 were considered severe. The group aged 51 to 64 was classified as severe, with a decrease in leukocytes (
p
-value 0.0295) and neutrophils (
p
-value 0.0476).
L. infantum
DNA was identified in blood and bone marrow, in 69 individuals, and not detected in 5 individuals. The quantification of the parasite showed greater parasitemia in bone marrow (
P
= 0.0003) with an average of 4.70 × 10
4
Leishmanias
/mL about blood, with 0.29 × 10
4
Leishmanias
/mL. Individuals in the age group aged 51 to 64 co-infected with HIV + VL had higher parasitemia (
p
-value 0.0150) with 2.44 × 10
4
Leishmanias
/mL in blood and bone marrow than in the group aged 20 to 50. Parasitemia, measured by molecular biology in blood and bone marrow, was related to the worst clinical prognosis of VL in the age group aged 51 to 64. |
| doi_str_mv | 10.1007/s12088-023-01182-6 |
| format | Article |
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Leishmania
, vector biology, host immune system evasion, and reservoir hosts. Parasitemia can be involved as a warning regarding the clinical severity of VL The present study aims to evaluate the relationship between parasitemia and the prognosis of individuals with VL. Blood and bone marrow samples from individuals with VL were analyzed to identify parasite and quantify or measure parasite burden. Individuals were classified in the clinical score model of risk of death by disease proposed by Coura-Vital et al. (PLoS Negl Trop Dis 8(12): e33742014, 2014). 39/74 individuals presented a better prognosis, and 35/74 individuals presented a worse prognosis. HIV + VL co-infection was present in 32 individuals, of which 12 were considered severe. The group aged 51 to 64 was classified as severe, with a decrease in leukocytes (
p
-value 0.0295) and neutrophils (
p
-value 0.0476).
L. infantum
DNA was identified in blood and bone marrow, in 69 individuals, and not detected in 5 individuals. The quantification of the parasite showed greater parasitemia in bone marrow (
P
= 0.0003) with an average of 4.70 × 10
4
Leishmanias
/mL about blood, with 0.29 × 10
4
Leishmanias
/mL. Individuals in the age group aged 51 to 64 co-infected with HIV + VL had higher parasitemia (
p
-value 0.0150) with 2.44 × 10
4
Leishmanias
/mL in blood and bone marrow than in the group aged 20 to 50. Parasitemia, measured by molecular biology in blood and bone marrow, was related to the worst clinical prognosis of VL in the age group aged 51 to 64.</description><identifier>ISSN: 0046-8991</identifier><identifier>EISSN: 0973-7715</identifier><identifier>DOI: 10.1007/s12088-023-01182-6</identifier><identifier>PMID: 39011003</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Age groups ; Biology ; Biomedical and Life Sciences ; Blood ; Bone marrow ; death ; DNA ; evolution ; HIV ; Human immunodeficiency virus ; Immune system ; Leishmania ; Leukocytes (neutrophilic) ; Life Sciences ; Medical Microbiology ; Microbiology ; mixed infection ; Molecular biology ; neutrophils ; Original Research Article ; Parasitemia ; Parasites ; Parasitic diseases ; Prognosis ; risk ; Risk analysis ; Vector-borne diseases ; Virulence ; Visceral leishmaniasis</subject><ispartof>Indian journal of microbiology, 2024-06, Vol.64 (2), p.511-519</ispartof><rights>Association of Microbiologists of India 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-c7bd34c25c845e27ed3f8e96275fa915516ad727b8b7c4971bb664bfce34a43a3</cites><orcidid>0000-0002-5342-7329</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12088-023-01182-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12088-023-01182-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39011003$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Campelo, Cássio Marinho</creatorcontrib><creatorcontrib>Medvedovsky, Andres Christopher</creatorcontrib><creatorcontrib>de Holanda, Pablo Eliak Linhares</creatorcontrib><creatorcontrib>de Oliveira, Denis Francisco Gonçalves</creatorcontrib><creatorcontrib>de Albuquerque-Pinto, Luiz Carlos</creatorcontrib><creatorcontrib>Melo, Luciana Magalhães</creatorcontrib><creatorcontrib>Câmara, Lilia Maria Carneiro</creatorcontrib><title>The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis</title><title>Indian journal of microbiology</title><addtitle>Indian J Microbiol</addtitle><addtitle>Indian J Microbiol</addtitle><description>Visceral leishmaniasis (VL) occurs due to the evolution, virulence, and adaptation of
Leishmania
, vector biology, host immune system evasion, and reservoir hosts. Parasitemia can be involved as a warning regarding the clinical severity of VL The present study aims to evaluate the relationship between parasitemia and the prognosis of individuals with VL. Blood and bone marrow samples from individuals with VL were analyzed to identify parasite and quantify or measure parasite burden. Individuals were classified in the clinical score model of risk of death by disease proposed by Coura-Vital et al. (PLoS Negl Trop Dis 8(12): e33742014, 2014). 39/74 individuals presented a better prognosis, and 35/74 individuals presented a worse prognosis. HIV + VL co-infection was present in 32 individuals, of which 12 were considered severe. The group aged 51 to 64 was classified as severe, with a decrease in leukocytes (
p
-value 0.0295) and neutrophils (
p
-value 0.0476).
L. infantum
DNA was identified in blood and bone marrow, in 69 individuals, and not detected in 5 individuals. The quantification of the parasite showed greater parasitemia in bone marrow (
P
= 0.0003) with an average of 4.70 × 10
4
Leishmanias
/mL about blood, with 0.29 × 10
4
Leishmanias
/mL. Individuals in the age group aged 51 to 64 co-infected with HIV + VL had higher parasitemia (
p
-value 0.0150) with 2.44 × 10
4
Leishmanias
/mL in blood and bone marrow than in the group aged 20 to 50. Parasitemia, measured by molecular biology in blood and bone marrow, was related to the worst clinical prognosis of VL in the age group aged 51 to 64.</description><subject>Age groups</subject><subject>Biology</subject><subject>Biomedical and Life Sciences</subject><subject>Blood</subject><subject>Bone marrow</subject><subject>death</subject><subject>DNA</subject><subject>evolution</subject><subject>HIV</subject><subject>Human immunodeficiency virus</subject><subject>Immune system</subject><subject>Leishmania</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>mixed infection</subject><subject>Molecular biology</subject><subject>neutrophils</subject><subject>Original Research Article</subject><subject>Parasitemia</subject><subject>Parasites</subject><subject>Parasitic diseases</subject><subject>Prognosis</subject><subject>risk</subject><subject>Risk analysis</subject><subject>Vector-borne diseases</subject><subject>Virulence</subject><subject>Visceral leishmaniasis</subject><issn>0046-8991</issn><issn>0973-7715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkUtLxDAUhYMozjj6B1xIwY2bah5N0iyl-IIBRUe3IW1vnQ59jEkrzL83taOCC13lQr5z7uMgdEzwOcFYXjhCcRyHmLIQExLTUOygKVaShVISvutrHIkwVopM0IFzK4y5UILvowlTXoAxm6LHxRKCB2ONKzuoSxMsjQuStulsmfYd5EHXBp1HnuAdbNltgrYIEuPADcVL6TKwpgrmULplbZrS27hDtFeYysHR9p2h5-urRXIbzu9v7pLLeZgxrrowk2nOoozyLI44UAk5K2JQgkpeGEU4J8Lkkso0TmUWKUnSVIgoLTJgkYmYYTN0NvqubfvWg-t0PcxTVaaBtneaEc6kv1OE_0dxTKiiVAzo6S901fa28Yt4SirFifQHnyE6UpltnbNQ6LUta2M3mmA9hKPHcLRn9Wc4WnjRyda6T2vIvyVfaXiAjYDzX80r2J_ef9h-AAyWmFc</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Campelo, Cássio Marinho</creator><creator>Medvedovsky, Andres Christopher</creator><creator>de Holanda, Pablo Eliak Linhares</creator><creator>de Oliveira, Denis Francisco Gonçalves</creator><creator>de Albuquerque-Pinto, Luiz Carlos</creator><creator>Melo, Luciana Magalhães</creator><creator>Câmara, Lilia Maria Carneiro</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-5342-7329</orcidid></search><sort><creationdate>20240601</creationdate><title>The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis</title><author>Campelo, Cássio Marinho ; Medvedovsky, Andres Christopher ; de Holanda, Pablo Eliak Linhares ; de Oliveira, Denis Francisco Gonçalves ; de Albuquerque-Pinto, Luiz Carlos ; Melo, Luciana Magalhães ; Câmara, Lilia Maria Carneiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-c7bd34c25c845e27ed3f8e96275fa915516ad727b8b7c4971bb664bfce34a43a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Age groups</topic><topic>Biology</topic><topic>Biomedical and Life Sciences</topic><topic>Blood</topic><topic>Bone marrow</topic><topic>death</topic><topic>DNA</topic><topic>evolution</topic><topic>HIV</topic><topic>Human immunodeficiency virus</topic><topic>Immune system</topic><topic>Leishmania</topic><topic>Leukocytes (neutrophilic)</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>mixed infection</topic><topic>Molecular biology</topic><topic>neutrophils</topic><topic>Original Research Article</topic><topic>Parasitemia</topic><topic>Parasites</topic><topic>Parasitic diseases</topic><topic>Prognosis</topic><topic>risk</topic><topic>Risk analysis</topic><topic>Vector-borne diseases</topic><topic>Virulence</topic><topic>Visceral leishmaniasis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Campelo, Cássio Marinho</creatorcontrib><creatorcontrib>Medvedovsky, Andres Christopher</creatorcontrib><creatorcontrib>de Holanda, Pablo Eliak Linhares</creatorcontrib><creatorcontrib>de Oliveira, Denis Francisco Gonçalves</creatorcontrib><creatorcontrib>de Albuquerque-Pinto, Luiz Carlos</creatorcontrib><creatorcontrib>Melo, Luciana Magalhães</creatorcontrib><creatorcontrib>Câmara, Lilia Maria Carneiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Indian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Campelo, Cássio Marinho</au><au>Medvedovsky, Andres Christopher</au><au>de Holanda, Pablo Eliak Linhares</au><au>de Oliveira, Denis Francisco Gonçalves</au><au>de Albuquerque-Pinto, Luiz Carlos</au><au>Melo, Luciana Magalhães</au><au>Câmara, Lilia Maria Carneiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis</atitle><jtitle>Indian journal of microbiology</jtitle><stitle>Indian J Microbiol</stitle><addtitle>Indian J Microbiol</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>64</volume><issue>2</issue><spage>511</spage><epage>519</epage><pages>511-519</pages><issn>0046-8991</issn><eissn>0973-7715</eissn><abstract>Visceral leishmaniasis (VL) occurs due to the evolution, virulence, and adaptation of
Leishmania
, vector biology, host immune system evasion, and reservoir hosts. Parasitemia can be involved as a warning regarding the clinical severity of VL The present study aims to evaluate the relationship between parasitemia and the prognosis of individuals with VL. Blood and bone marrow samples from individuals with VL were analyzed to identify parasite and quantify or measure parasite burden. Individuals were classified in the clinical score model of risk of death by disease proposed by Coura-Vital et al. (PLoS Negl Trop Dis 8(12): e33742014, 2014). 39/74 individuals presented a better prognosis, and 35/74 individuals presented a worse prognosis. HIV + VL co-infection was present in 32 individuals, of which 12 were considered severe. The group aged 51 to 64 was classified as severe, with a decrease in leukocytes (
p
-value 0.0295) and neutrophils (
p
-value 0.0476).
L. infantum
DNA was identified in blood and bone marrow, in 69 individuals, and not detected in 5 individuals. The quantification of the parasite showed greater parasitemia in bone marrow (
P
= 0.0003) with an average of 4.70 × 10
4
Leishmanias
/mL about blood, with 0.29 × 10
4
Leishmanias
/mL. Individuals in the age group aged 51 to 64 co-infected with HIV + VL had higher parasitemia (
p
-value 0.0150) with 2.44 × 10
4
Leishmanias
/mL in blood and bone marrow than in the group aged 20 to 50. Parasitemia, measured by molecular biology in blood and bone marrow, was related to the worst clinical prognosis of VL in the age group aged 51 to 64.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>39011003</pmid><doi>10.1007/s12088-023-01182-6</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5342-7329</orcidid></addata></record> |
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| ispartof | Indian journal of microbiology, 2024-06, Vol.64 (2), p.511-519 |
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| source | SpringerLink Journals |
| subjects | Age groups Biology Biomedical and Life Sciences Blood Bone marrow death DNA evolution HIV Human immunodeficiency virus Immune system Leishmania Leukocytes (neutrophilic) Life Sciences Medical Microbiology Microbiology mixed infection Molecular biology neutrophils Original Research Article Parasitemia Parasites Parasitic diseases Prognosis risk Risk analysis Vector-borne diseases Virulence Visceral leishmaniasis |
| title | The Parasitemia has Contributed to the Severity of Cases of Visceral Leishmaniasis |
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