De novo design of mini-binder proteins against IL-2 receptor β chain

IL-2 regulates the immune response by interacting with different IL-2 receptor (IL-2R) subunits. High dose of IL-2 binds to IL-2Rβγc heterodimer, which induce various side effects while activating immune function. Disrupting IL-2 and IL-2R interactions can block IL-2 mediated immune response. Here,...

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Veröffentlicht in:	International journal of biological macromolecules 2024-09, Vol.276 (Pt 1), p.133834, Article 133834
Hauptverfasser:	Ming, Ke, Xing, Banbin, Ren, Xinyi, Hu, Yang, Wei, Lin, Wang, Zhizheng, Mei, Meng, Weng, Jun, Wei, Zigong
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acids Animals Cell Proliferation - drug effects Gibbs free energy Humans hydrophobicity IL-2 receptor immune response interleukin-2 Interleukin-2 - chemistry Interleukin-2 - metabolism Interleukin-2 Receptor beta Subunit - chemistry Interleukin-2 Receptor beta Subunit - metabolism mini-binders Molecular Docking Simulation molecular dynamics Molecular Dynamics Simulation phosphorylation Phosphorylation - drug effects Protein Binding Protein de novo design STAT5 Transcription Factor - metabolism
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