Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children
Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However...
Gespeichert in:
| Veröffentlicht in: | Environmental research 2024-10, Vol.259, p.119496, Article 119496 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 119496 |
| container_title | Environmental research |
| container_volume | 259 |
| creator | Li, Yijie Baumert, Brittney O. Stratakis, Nikos Goodrich, Jesse A. Wu, Haotian Liu, Shelley H. Wang, Hongxu Beglarian, Emily Bartell, Scott M. Eckel, Sandrah Proctor Walker, Douglas Valvi, Damaskini La Merrill, Michele Andrea Inge, Thomas H. Jenkins, Todd Ryder, Justin R. Sisley, Stephanie Kohli, Rohit Xanthakos, Stavra A. Vafeiadi, Marina Margetaki, Aikaterini Roumeliotaki, Theano Aung, Max McConnell, Rob Baccarelli, Andrea Conti, David Chatzi, Lida |
| description | Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.
To investigate associations between PFAS concentrations and miRNA levels in children.
Data from two distinct cohorts were utilized: 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from the Rhea study, a mother-child cohort in Greece. PFAS concentrations and miRNA levels were assessed in plasma samples from both studies. Associations between individual PFAS and plasma miRNA levels were examined after adjusting for covariates. Additionally, the cumulative effects of PFAS mixtures were evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed to identify potential disease functions of PFAS-associated miRNAs.
Plasma PFAS concentrations were associated with alterations in 475 miRNAs in the Teen-LABs study and 5 miRNAs in the Rhea study (FDR p |
| doi_str_mv | 10.1016/j.envres.2024.119496 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153681048</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0013935124014014</els_id><sourcerecordid>3153681048</sourcerecordid><originalsourceid>FETCH-LOGICAL-c274t-8a680bc8b483c05b4fbf6374d49dde6b28718b847a4a1be45f59539755d1b15e3</originalsourceid><addsrcrecordid>eNqFkctu1TAQhi0EoofCGyDkJZsc7NhO7A1SVZWLVLVSVdaWLxPwwYmDnVQ9b4_bFJawGo3mm9v_I_SWkj0ltPtw2MN0l6HsW9LyPaWKq-4Z2lGiuoYowZ6jHSGUNYoJeoJelXKoKRWMvEQnTCrWcdXv0PeL-zmVNQNeEp4hN9hMHs8pHoe4ppxM_HmMuKy2LGZyUB7LJi6QzRLSVHCY8BxNGQ0eg8vp5uoMzzkNIcJjzf0I0WeYXqMXg4kF3jzFU_Tt08Xt-Zfm8vrz1_Ozy8a1PV8aaTpJrJOWS-aIsHywQ8d67rnyHjrbyp5KK3lvuKEWuBhEfVX1QnhqqQB2it5vc-sRv1Yoix5DcRCjmSCtRbOqQCcpqfP_i5KetYzIlleUb2j9sJQMg55zGE0-akr0gxv6oDc39IMbenOjtr172rDaEfzfpj_yV-DjBkCV5C5A1sUFqDr7kMEt2qfw7w2_AR7vne0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3073230824</pqid></control><display><type>article</type><title>Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Li, Yijie ; Baumert, Brittney O. ; Stratakis, Nikos ; Goodrich, Jesse A. ; Wu, Haotian ; Liu, Shelley H. ; Wang, Hongxu ; Beglarian, Emily ; Bartell, Scott M. ; Eckel, Sandrah Proctor ; Walker, Douglas ; Valvi, Damaskini ; La Merrill, Michele Andrea ; Inge, Thomas H. ; Jenkins, Todd ; Ryder, Justin R. ; Sisley, Stephanie ; Kohli, Rohit ; Xanthakos, Stavra A. ; Vafeiadi, Marina ; Margetaki, Aikaterini ; Roumeliotaki, Theano ; Aung, Max ; McConnell, Rob ; Baccarelli, Andrea ; Conti, David ; Chatzi, Lida</creator><creatorcontrib>Li, Yijie ; Baumert, Brittney O. ; Stratakis, Nikos ; Goodrich, Jesse A. ; Wu, Haotian ; Liu, Shelley H. ; Wang, Hongxu ; Beglarian, Emily ; Bartell, Scott M. ; Eckel, Sandrah Proctor ; Walker, Douglas ; Valvi, Damaskini ; La Merrill, Michele Andrea ; Inge, Thomas H. ; Jenkins, Todd ; Ryder, Justin R. ; Sisley, Stephanie ; Kohli, Rohit ; Xanthakos, Stavra A. ; Vafeiadi, Marina ; Margetaki, Aikaterini ; Roumeliotaki, Theano ; Aung, Max ; McConnell, Rob ; Baccarelli, Andrea ; Conti, David ; Chatzi, Lida</creatorcontrib><description>Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.
To investigate associations between PFAS concentrations and miRNA levels in children.
Data from two distinct cohorts were utilized: 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from the Rhea study, a mother-child cohort in Greece. PFAS concentrations and miRNA levels were assessed in plasma samples from both studies. Associations between individual PFAS and plasma miRNA levels were examined after adjusting for covariates. Additionally, the cumulative effects of PFAS mixtures were evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed to identify potential disease functions of PFAS-associated miRNAs.
Plasma PFAS concentrations were associated with alterations in 475 miRNAs in the Teen-LABs study and 5 miRNAs in the Rhea study (FDR p < 0.1). Specifically, plasma PFAS concentrations were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p in both cohorts. Pathway analysis indicated that PFAS-related miRNAs were linked to numerous chronic disease pathways, including cardiovascular diseases, inflammatory conditions, and carcinogenesis.
Through miRNA screenings in two independent cohorts, this study identified both known and novel miRNAs associated with PFAS exposure in children. Pathway analysis revealed the involvement of these miRNAs in several cancer and inflammation-related pathways. Further studies are warranted to enhance our understanding of the relationships between PFAS exposure and disease risks, with miRNA emerging as potential biomarkers and/or mediators in these complex pathways.
•Per- and polyfluoroalkyl substances (PFAS) were significantly associated with plasma microRNAs (miRNAs) in children.•PFAS were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p across distinct cohorts of children.•PFAS mixtures exhibited similar effects on miRNA alterations as individual PFAS congeners.•Significant PFAS-related miRNAs play an essential role in tumorigenesis.</description><identifier>ISSN: 0013-9351</identifier><identifier>ISSN: 1096-0953</identifier><identifier>EISSN: 1096-0953</identifier><identifier>DOI: 10.1016/j.envres.2024.119496</identifier><identifier>PMID: 38936497</identifier><language>eng</language><publisher>Netherlands: Elsevier Inc</publisher><subject>Adolescent ; bariatric surgery ; biomarkers ; Biomarkers - blood ; Carcinogenesis ; Child ; chronic diseases ; Cohort Studies ; Environmental Exposure - adverse effects ; Environmental Pollutants - blood ; Female ; females ; Fluorocarbons - blood ; Greece ; human health ; Humans ; Longitudinal Studies ; Male ; MicroRNA ; MicroRNAs - blood ; Per- and polyfluoroalkyl substances ; Persistent organic pollutants ; Rhea ; Transcriptomics ; United States</subject><ispartof>Environmental research, 2024-10, Vol.259, p.119496, Article 119496</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c274t-8a680bc8b483c05b4fbf6374d49dde6b28718b847a4a1be45f59539755d1b15e3</cites><orcidid>0000-0003-2900-7014 ; 0000-0002-0198-7703 ; 0000-0002-2941-7833 ; 0000-0001-9955-1985 ; 0000-0003-2171-059X ; 0000-0001-7797-2906 ; 0000-0003-4633-229X ; 0000-0001-7551-117X ; 0000-0001-5541-5447 ; 0000-0003-1220-8557 ; 0000-0002-3578-4437 ; 0000-0002-6271-0249 ; 0000-0002-5044-983X ; 0000-0001-6615-0472</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0013935124014014$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38936497$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Yijie</creatorcontrib><creatorcontrib>Baumert, Brittney O.</creatorcontrib><creatorcontrib>Stratakis, Nikos</creatorcontrib><creatorcontrib>Goodrich, Jesse A.</creatorcontrib><creatorcontrib>Wu, Haotian</creatorcontrib><creatorcontrib>Liu, Shelley H.</creatorcontrib><creatorcontrib>Wang, Hongxu</creatorcontrib><creatorcontrib>Beglarian, Emily</creatorcontrib><creatorcontrib>Bartell, Scott M.</creatorcontrib><creatorcontrib>Eckel, Sandrah Proctor</creatorcontrib><creatorcontrib>Walker, Douglas</creatorcontrib><creatorcontrib>Valvi, Damaskini</creatorcontrib><creatorcontrib>La Merrill, Michele Andrea</creatorcontrib><creatorcontrib>Inge, Thomas H.</creatorcontrib><creatorcontrib>Jenkins, Todd</creatorcontrib><creatorcontrib>Ryder, Justin R.</creatorcontrib><creatorcontrib>Sisley, Stephanie</creatorcontrib><creatorcontrib>Kohli, Rohit</creatorcontrib><creatorcontrib>Xanthakos, Stavra A.</creatorcontrib><creatorcontrib>Vafeiadi, Marina</creatorcontrib><creatorcontrib>Margetaki, Aikaterini</creatorcontrib><creatorcontrib>Roumeliotaki, Theano</creatorcontrib><creatorcontrib>Aung, Max</creatorcontrib><creatorcontrib>McConnell, Rob</creatorcontrib><creatorcontrib>Baccarelli, Andrea</creatorcontrib><creatorcontrib>Conti, David</creatorcontrib><creatorcontrib>Chatzi, Lida</creatorcontrib><title>Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children</title><title>Environmental research</title><addtitle>Environ Res</addtitle><description>Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.
To investigate associations between PFAS concentrations and miRNA levels in children.
Data from two distinct cohorts were utilized: 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from the Rhea study, a mother-child cohort in Greece. PFAS concentrations and miRNA levels were assessed in plasma samples from both studies. Associations between individual PFAS and plasma miRNA levels were examined after adjusting for covariates. Additionally, the cumulative effects of PFAS mixtures were evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed to identify potential disease functions of PFAS-associated miRNAs.
Plasma PFAS concentrations were associated with alterations in 475 miRNAs in the Teen-LABs study and 5 miRNAs in the Rhea study (FDR p < 0.1). Specifically, plasma PFAS concentrations were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p in both cohorts. Pathway analysis indicated that PFAS-related miRNAs were linked to numerous chronic disease pathways, including cardiovascular diseases, inflammatory conditions, and carcinogenesis.
Through miRNA screenings in two independent cohorts, this study identified both known and novel miRNAs associated with PFAS exposure in children. Pathway analysis revealed the involvement of these miRNAs in several cancer and inflammation-related pathways. Further studies are warranted to enhance our understanding of the relationships between PFAS exposure and disease risks, with miRNA emerging as potential biomarkers and/or mediators in these complex pathways.
•Per- and polyfluoroalkyl substances (PFAS) were significantly associated with plasma microRNAs (miRNAs) in children.•PFAS were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p across distinct cohorts of children.•PFAS mixtures exhibited similar effects on miRNA alterations as individual PFAS congeners.•Significant PFAS-related miRNAs play an essential role in tumorigenesis.</description><subject>Adolescent</subject><subject>bariatric surgery</subject><subject>biomarkers</subject><subject>Biomarkers - blood</subject><subject>Carcinogenesis</subject><subject>Child</subject><subject>chronic diseases</subject><subject>Cohort Studies</subject><subject>Environmental Exposure - adverse effects</subject><subject>Environmental Pollutants - blood</subject><subject>Female</subject><subject>females</subject><subject>Fluorocarbons - blood</subject><subject>Greece</subject><subject>human health</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>MicroRNA</subject><subject>MicroRNAs - blood</subject><subject>Per- and polyfluoroalkyl substances</subject><subject>Persistent organic pollutants</subject><subject>Rhea</subject><subject>Transcriptomics</subject><subject>United States</subject><issn>0013-9351</issn><issn>1096-0953</issn><issn>1096-0953</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctu1TAQhi0EoofCGyDkJZsc7NhO7A1SVZWLVLVSVdaWLxPwwYmDnVQ9b4_bFJawGo3mm9v_I_SWkj0ltPtw2MN0l6HsW9LyPaWKq-4Z2lGiuoYowZ6jHSGUNYoJeoJelXKoKRWMvEQnTCrWcdXv0PeL-zmVNQNeEp4hN9hMHs8pHoe4ppxM_HmMuKy2LGZyUB7LJi6QzRLSVHCY8BxNGQ0eg8vp5uoMzzkNIcJjzf0I0WeYXqMXg4kF3jzFU_Tt08Xt-Zfm8vrz1_Ozy8a1PV8aaTpJrJOWS-aIsHywQ8d67rnyHjrbyp5KK3lvuKEWuBhEfVX1QnhqqQB2it5vc-sRv1Yoix5DcRCjmSCtRbOqQCcpqfP_i5KetYzIlleUb2j9sJQMg55zGE0-akr0gxv6oDc39IMbenOjtr172rDaEfzfpj_yV-DjBkCV5C5A1sUFqDr7kMEt2qfw7w2_AR7vne0</recordid><startdate>20241015</startdate><enddate>20241015</enddate><creator>Li, Yijie</creator><creator>Baumert, Brittney O.</creator><creator>Stratakis, Nikos</creator><creator>Goodrich, Jesse A.</creator><creator>Wu, Haotian</creator><creator>Liu, Shelley H.</creator><creator>Wang, Hongxu</creator><creator>Beglarian, Emily</creator><creator>Bartell, Scott M.</creator><creator>Eckel, Sandrah Proctor</creator><creator>Walker, Douglas</creator><creator>Valvi, Damaskini</creator><creator>La Merrill, Michele Andrea</creator><creator>Inge, Thomas H.</creator><creator>Jenkins, Todd</creator><creator>Ryder, Justin R.</creator><creator>Sisley, Stephanie</creator><creator>Kohli, Rohit</creator><creator>Xanthakos, Stavra A.</creator><creator>Vafeiadi, Marina</creator><creator>Margetaki, Aikaterini</creator><creator>Roumeliotaki, Theano</creator><creator>Aung, Max</creator><creator>McConnell, Rob</creator><creator>Baccarelli, Andrea</creator><creator>Conti, David</creator><creator>Chatzi, Lida</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-2900-7014</orcidid><orcidid>https://orcid.org/0000-0002-0198-7703</orcidid><orcidid>https://orcid.org/0000-0002-2941-7833</orcidid><orcidid>https://orcid.org/0000-0001-9955-1985</orcidid><orcidid>https://orcid.org/0000-0003-2171-059X</orcidid><orcidid>https://orcid.org/0000-0001-7797-2906</orcidid><orcidid>https://orcid.org/0000-0003-4633-229X</orcidid><orcidid>https://orcid.org/0000-0001-7551-117X</orcidid><orcidid>https://orcid.org/0000-0001-5541-5447</orcidid><orcidid>https://orcid.org/0000-0003-1220-8557</orcidid><orcidid>https://orcid.org/0000-0002-3578-4437</orcidid><orcidid>https://orcid.org/0000-0002-6271-0249</orcidid><orcidid>https://orcid.org/0000-0002-5044-983X</orcidid><orcidid>https://orcid.org/0000-0001-6615-0472</orcidid></search><sort><creationdate>20241015</creationdate><title>Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children</title><author>Li, Yijie ; Baumert, Brittney O. ; Stratakis, Nikos ; Goodrich, Jesse A. ; Wu, Haotian ; Liu, Shelley H. ; Wang, Hongxu ; Beglarian, Emily ; Bartell, Scott M. ; Eckel, Sandrah Proctor ; Walker, Douglas ; Valvi, Damaskini ; La Merrill, Michele Andrea ; Inge, Thomas H. ; Jenkins, Todd ; Ryder, Justin R. ; Sisley, Stephanie ; Kohli, Rohit ; Xanthakos, Stavra A. ; Vafeiadi, Marina ; Margetaki, Aikaterini ; Roumeliotaki, Theano ; Aung, Max ; McConnell, Rob ; Baccarelli, Andrea ; Conti, David ; Chatzi, Lida</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c274t-8a680bc8b483c05b4fbf6374d49dde6b28718b847a4a1be45f59539755d1b15e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>bariatric surgery</topic><topic>biomarkers</topic><topic>Biomarkers - blood</topic><topic>Carcinogenesis</topic><topic>Child</topic><topic>chronic diseases</topic><topic>Cohort Studies</topic><topic>Environmental Exposure - adverse effects</topic><topic>Environmental Pollutants - blood</topic><topic>Female</topic><topic>females</topic><topic>Fluorocarbons - blood</topic><topic>Greece</topic><topic>human health</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>MicroRNA</topic><topic>MicroRNAs - blood</topic><topic>Per- and polyfluoroalkyl substances</topic><topic>Persistent organic pollutants</topic><topic>Rhea</topic><topic>Transcriptomics</topic><topic>United States</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Yijie</creatorcontrib><creatorcontrib>Baumert, Brittney O.</creatorcontrib><creatorcontrib>Stratakis, Nikos</creatorcontrib><creatorcontrib>Goodrich, Jesse A.</creatorcontrib><creatorcontrib>Wu, Haotian</creatorcontrib><creatorcontrib>Liu, Shelley H.</creatorcontrib><creatorcontrib>Wang, Hongxu</creatorcontrib><creatorcontrib>Beglarian, Emily</creatorcontrib><creatorcontrib>Bartell, Scott M.</creatorcontrib><creatorcontrib>Eckel, Sandrah Proctor</creatorcontrib><creatorcontrib>Walker, Douglas</creatorcontrib><creatorcontrib>Valvi, Damaskini</creatorcontrib><creatorcontrib>La Merrill, Michele Andrea</creatorcontrib><creatorcontrib>Inge, Thomas H.</creatorcontrib><creatorcontrib>Jenkins, Todd</creatorcontrib><creatorcontrib>Ryder, Justin R.</creatorcontrib><creatorcontrib>Sisley, Stephanie</creatorcontrib><creatorcontrib>Kohli, Rohit</creatorcontrib><creatorcontrib>Xanthakos, Stavra A.</creatorcontrib><creatorcontrib>Vafeiadi, Marina</creatorcontrib><creatorcontrib>Margetaki, Aikaterini</creatorcontrib><creatorcontrib>Roumeliotaki, Theano</creatorcontrib><creatorcontrib>Aung, Max</creatorcontrib><creatorcontrib>McConnell, Rob</creatorcontrib><creatorcontrib>Baccarelli, Andrea</creatorcontrib><creatorcontrib>Conti, David</creatorcontrib><creatorcontrib>Chatzi, Lida</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Environmental research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Yijie</au><au>Baumert, Brittney O.</au><au>Stratakis, Nikos</au><au>Goodrich, Jesse A.</au><au>Wu, Haotian</au><au>Liu, Shelley H.</au><au>Wang, Hongxu</au><au>Beglarian, Emily</au><au>Bartell, Scott M.</au><au>Eckel, Sandrah Proctor</au><au>Walker, Douglas</au><au>Valvi, Damaskini</au><au>La Merrill, Michele Andrea</au><au>Inge, Thomas H.</au><au>Jenkins, Todd</au><au>Ryder, Justin R.</au><au>Sisley, Stephanie</au><au>Kohli, Rohit</au><au>Xanthakos, Stavra A.</au><au>Vafeiadi, Marina</au><au>Margetaki, Aikaterini</au><au>Roumeliotaki, Theano</au><au>Aung, Max</au><au>McConnell, Rob</au><au>Baccarelli, Andrea</au><au>Conti, David</au><au>Chatzi, Lida</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children</atitle><jtitle>Environmental research</jtitle><addtitle>Environ Res</addtitle><date>2024-10-15</date><risdate>2024</risdate><volume>259</volume><spage>119496</spage><pages>119496-</pages><artnum>119496</artnum><issn>0013-9351</issn><issn>1096-0953</issn><eissn>1096-0953</eissn><abstract>Per- and polyfluoroalkyl substances (PFAS) are synthetic chemicals that persist in the environment and can accumulate in humans, leading to adverse health effects. MicroRNAs (miRNAs) are emerging biomarkers that can advance the understanding of the mechanisms of PFAS effects on human health. However, little is known about the associations between PFAS exposures and miRNA alterations in humans.
To investigate associations between PFAS concentrations and miRNA levels in children.
Data from two distinct cohorts were utilized: 176 participants (average age 17.1 years; 75.6% female) from the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) cohort in the United States, and 64 participants (average age 6.5 years, 39.1% female) from the Rhea study, a mother-child cohort in Greece. PFAS concentrations and miRNA levels were assessed in plasma samples from both studies. Associations between individual PFAS and plasma miRNA levels were examined after adjusting for covariates. Additionally, the cumulative effects of PFAS mixtures were evaluated using an exposure burden score. Ingenuity Pathways Analysis was employed to identify potential disease functions of PFAS-associated miRNAs.
Plasma PFAS concentrations were associated with alterations in 475 miRNAs in the Teen-LABs study and 5 miRNAs in the Rhea study (FDR p < 0.1). Specifically, plasma PFAS concentrations were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p in both cohorts. Pathway analysis indicated that PFAS-related miRNAs were linked to numerous chronic disease pathways, including cardiovascular diseases, inflammatory conditions, and carcinogenesis.
Through miRNA screenings in two independent cohorts, this study identified both known and novel miRNAs associated with PFAS exposure in children. Pathway analysis revealed the involvement of these miRNAs in several cancer and inflammation-related pathways. Further studies are warranted to enhance our understanding of the relationships between PFAS exposure and disease risks, with miRNA emerging as potential biomarkers and/or mediators in these complex pathways.
•Per- and polyfluoroalkyl substances (PFAS) were significantly associated with plasma microRNAs (miRNAs) in children.•PFAS were consistently associated with decreased levels of miR-148b-3p and miR-29a-3p across distinct cohorts of children.•PFAS mixtures exhibited similar effects on miRNA alterations as individual PFAS congeners.•Significant PFAS-related miRNAs play an essential role in tumorigenesis.</abstract><cop>Netherlands</cop><pub>Elsevier Inc</pub><pmid>38936497</pmid><doi>10.1016/j.envres.2024.119496</doi><orcidid>https://orcid.org/0000-0003-2900-7014</orcidid><orcidid>https://orcid.org/0000-0002-0198-7703</orcidid><orcidid>https://orcid.org/0000-0002-2941-7833</orcidid><orcidid>https://orcid.org/0000-0001-9955-1985</orcidid><orcidid>https://orcid.org/0000-0003-2171-059X</orcidid><orcidid>https://orcid.org/0000-0001-7797-2906</orcidid><orcidid>https://orcid.org/0000-0003-4633-229X</orcidid><orcidid>https://orcid.org/0000-0001-7551-117X</orcidid><orcidid>https://orcid.org/0000-0001-5541-5447</orcidid><orcidid>https://orcid.org/0000-0003-1220-8557</orcidid><orcidid>https://orcid.org/0000-0002-3578-4437</orcidid><orcidid>https://orcid.org/0000-0002-6271-0249</orcidid><orcidid>https://orcid.org/0000-0002-5044-983X</orcidid><orcidid>https://orcid.org/0000-0001-6615-0472</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0013-9351 |
| ispartof | Environmental research, 2024-10, Vol.259, p.119496, Article 119496 |
| issn | 0013-9351 1096-0953 1096-0953 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153681048 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Adolescent bariatric surgery biomarkers Biomarkers - blood Carcinogenesis Child chronic diseases Cohort Studies Environmental Exposure - adverse effects Environmental Pollutants - blood Female females Fluorocarbons - blood Greece human health Humans Longitudinal Studies Male MicroRNA MicroRNAs - blood Per- and polyfluoroalkyl substances Persistent organic pollutants Rhea Transcriptomics United States |
| title | Exposure to per- and polyfluoroalkyl substances and alterations in plasma microRNA profiles in children |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T14%3A34%3A05IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exposure%20to%20per-%20and%20polyfluoroalkyl%20substances%20and%20alterations%20in%20plasma%20microRNA%20profiles%20in%20children&rft.jtitle=Environmental%20research&rft.au=Li,%20Yijie&rft.date=2024-10-15&rft.volume=259&rft.spage=119496&rft.pages=119496-&rft.artnum=119496&rft.issn=0013-9351&rft.eissn=1096-0953&rft_id=info:doi/10.1016/j.envres.2024.119496&rft_dat=%3Cproquest_cross%3E3153681048%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3073230824&rft_id=info:pmid/38936497&rft_els_id=S0013935124014014&rfr_iscdi=true |