Redox-neutral access to isoquinolines via cobalt(III)-catalyzed C H acylmethylation/cyclization of benzimidates with sulfoxonium ylides
A practical and highly efficient method for the regioselective synthesis of isoquinolines was developed via cobalt-catalyzed C(sp²)−H activation and subsequent intramolecular tandem annulations between benzimidates and sulfoxonium ylides. Key to the success of this transformation was the use of an i...
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| Veröffentlicht in: | Tetrahedron letters 2024-08, Vol.146, p.155185, Article 155185 |
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| creator | Li, Min Xia, Zhen Tang, Lixing Zhang, Bensong Yan, Fupeng Jiao, Yukun Xiang, Shiqi Zhang, Shiyu Tan, Ze Yu, Lin |
| description | A practical and highly efficient method for the regioselective synthesis of isoquinolines was developed via cobalt-catalyzed C(sp²)−H activation and subsequent intramolecular tandem annulations between benzimidates and sulfoxonium ylides. Key to the success of this transformation was the use of an inexpensive and bench-stable Cp*Co(III)-catalyst. Various functionalized isoquinolines were prepared successfully under base-free and oxidant-free conditions. This protocol features simple operation, broad substrate scope, and good functional group tolerance. Moreover, the reaction is scalable and tolerant of ambient air and moisture. |
| doi_str_mv | 10.1016/j.tetlet.2024.155185 |
| format | Article |
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| language | eng |
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| source | Elsevier ScienceDirect Journals Complete |
| subjects | air cobalt isoquinolines regioselectivity |
| title | Redox-neutral access to isoquinolines via cobalt(III)-catalyzed C H acylmethylation/cyclization of benzimidates with sulfoxonium ylides |
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