Spectroscopically Validated pH-dependent MSOX Movies Provide Detailed Mechanism of Copper Nitrite Reductases

[Display omitted] •Strength of combining on-line spectroscopy with the MSOX structural movie approach from one crystal.•Combination of MSOX and spectroscopy has wider implications for studying enzymatic reactions.•We conclusively demonstrate that the lower activity at high pH results from the loss o...

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Veröffentlicht in:	Journal of molecular biology 2024-09, Vol.436 (18), p.168706, Article 168706
Hauptverfasser:	Rose, Samuel L., Ferroni, Felix Martín, Horrell, Sam, Brondino, Carlos Dante, Eady, Robert R., Jaho, Sofia, Hough, Michael A., Owen, Robin L., Antonyuk, Svetlana V., Hasnain, S. Samar
Format:	Artikel
Sprache:	eng
Schlagworte:	carbon dioxide catalysis catalytic activity Catalytic Domain Copper - chemistry Copper - metabolism crystallography Crystallography, X-Ray decarboxylation denitrification electron transfer enzyme activity Hydrogen-Ion Concentration Models, Molecular molecular biology nitric oxide Nitric Oxide - chemistry Nitric Oxide - metabolism Nitrite Reductases - chemistry Nitrite Reductases - metabolism nitrites Oxidation-Reduction oxidoreductases Protein Conformation proton transfer species spectroscopy Spectrum Analysis - methods substrate utilisation X-radiation
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