Immunogenicity and immunoprotection of the functional TL-HN fragment derived from tetanus toxin

•TL-HN afforded the best immunoprotection among all the TeNT functional domains.•TL + THN combination showed no synergistic effect on protective potency against TeNT.•There are important neutralizing antibody epitopes at L and HN domains of TeNT.•TL-HN lacking the Hc domain is a good candidate subun...

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Veröffentlicht in:	Vaccine 2023-11, Vol.41 (46), p.6834-6841
Hauptverfasser:	Liu, Xu-Yang, Wei, Dong-Kui, Li, Zhi-Ying, Lu, Jian-Sheng, Xie, Xin-Mei, Yu, Yun-Zhou, Pang, Xiao-Bin
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Animal models Animals Antibodies Antibodies, Bacterial - blood Antibodies, Bacterial - immunology Antibodies, Neutralizing - immunology Antigens Botulinum toxin Chemical bonds Clostridium tetani Cytoplasm disulfide bonds domain E coli Epitopes Female Fragments Functional domain Immune protection Immunization Immunogenicity Immunology Laboratory animals Mice Mice, Inbred BALB C Neurotoxicity Neurotoxins Paralysis Peptide Fragments - immunology Plasmids Poisoning Protective antigen protective effect Proteins Rhabdomyolysis Subunit vaccine subunit vaccines Tetanus Tetanus - immunology Tetanus - prevention & control Tetanus toxin Tetanus Toxin - immunology TL-HN fragment Toxins Translocation Vaccines
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