Non-invasive urine-based ELISA using a recombinant Leishmania protein to diagnose tegumentary leishmaniasis

•The rLiHyV protein, synthetic peptides and SLA were used as antigens in ELISA.•They were tested against paired urine and serum samples from 215 patients to diagnose TL.•The recombinant protein presented better sensitivity and specificity values.•Patients’ urine showed better performance as biologic...

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Veröffentlicht in:	Acta tropica 2024-10, Vol.258, p.107326, Article 107326
Hauptverfasser:	Câmara, Raquel S.B., Pereira, Isabela A.G., Lage, Daniela P., Vale, Danniele L., Ludolf, Fernanda, Cardoso, Mariana M, Freitas, Camila S., Oliveira-da-Silva, João A., Assis, Bárbara P.N., Chaves, Ana T., Pimenta, Breno L., Silva, Marcela G.P., Tavares, Grasiele S.V., Galdino, Alexsandro S., Tupinambás, Unaí, Chávez-Fumagalli, Miguel A., Pascoal, Vanessa P.M., Eller, Marcela T.C., Rocha, Manoel O. da Costa, Machado-de-Ávila, Ricardo A., Gonçalves, Denise U., Coelho, Eduardo A.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Aged amino acid sequences Antibodies, Protozoan - blood Antibodies, Protozoan - urine Antigens, Protozoan - immunology Antigens, Protozoan - urine B-lymphocytes blood sampling blood serum Child Child, Preschool Diagnosis Enzyme-Linked Immunosorbent Assay - methods epitopes Epitopes, B-Lymphocyte - immunology Female Humans infrastructure Leishmania Leishmania - immunology Leishmaniasis, Cutaneous - diagnosis Leishmaniasis, Cutaneous - urine Male Middle Aged patients Protozoan Proteins - immunology Protozoan Proteins - urine Recombinant protein Recombinant Proteins - immunology Recombinant Proteins - urine Sensitivity and Specificity Serum Synthetic peptide Tegumentary leishmaniasis Urine Urine - chemistry Urine - parasitology visceral leishmaniasis Young Adult
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