Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide
Introduction Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as Leptospira. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S...
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| Veröffentlicht in: | Zoonoses and public health 2024-08, Vol.71 (5), p.457-468 |
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| creator | Matiz‐González, J. Manuel Ballesteros‐Ballesteros, Jesús A. Hernández, María Mejorano‐Fonseca, Julián A. Cuervo, Claudia Faccini‐Martínez, Álvaro A. Hidalgo, Marylin Pérez‐Torres, Jairo Silva‐Ramos, Carlos Ramiro |
| description | Introduction
Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as Leptospira. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. Leptospira has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.
Aim
The aim of the present study was to determine the genetic diversity of Leptospira spp. harboured by bats worldwide.
Methods
A systematic review was conducted on four databases to retrieve studies in which Leptospira was detected from bats. All studies were screened to retrieve all available Leptospira spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of Leptospira species and analysed through phylogenetic analysis.
Results
A total of 418 Leptospira spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic Leptospira spp. were identified, three of them composed exclusively of sequences obtained from bats.
Conclusion
We identified that bats harbour a great genetic diversity of Leptospira spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis‐associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic Leptospira spp. |
| doi_str_mv | 10.1111/zph.13126 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153669786</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3073884799</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3466-839bfad2a0f554124e14a3cf7e8a1f7ed6cc2966fe30f13e13fee9d269629c913</originalsourceid><addsrcrecordid>eNqF0UFLwzAYBuAgitPpwT8gBS962Jb0a9PmKKJOGLqDXryELP3iMrqlJp1j_nqjmx4EMYckkIcXvryEnDDaZ3EN3ptpnwFL-Q45YCWHXgpFubu9M5GLDjkMYUZpngta7JMOlDkVGYgDcn-LC2ytTir7hj7Ydp04k4zZoFHt1L3gIj6NsGldaKxXSWhQWwzJ1IUWq2SyTiaqDcnK-bpa2QqPyJ5RdcDj7dklTzfXj1fD3ujh9u7qctTTkHHeK0FMjKpSRU2eZyzNkGUKtCmwVCzuFdc6FZwbBGoYIAODKKqUC54KLRh0yfkmt_HudYmhlXMbNNa1WqBbBgksB85FET_gP5qKAhiNPov07BeduaVfxEEk0ALKMiuEiOpio7R3IXg0svF2rvxaMio_-5CxD_nVR7Sn28TlZI7Vj_wuIILBBqxsjeu_k-TzeLiJ_ABAYZOD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3073884799</pqid></control><display><type>article</type><title>Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Matiz‐González, J. Manuel ; Ballesteros‐Ballesteros, Jesús A. ; Hernández, María ; Mejorano‐Fonseca, Julián A. ; Cuervo, Claudia ; Faccini‐Martínez, Álvaro A. ; Hidalgo, Marylin ; Pérez‐Torres, Jairo ; Silva‐Ramos, Carlos Ramiro</creator><creatorcontrib>Matiz‐González, J. Manuel ; Ballesteros‐Ballesteros, Jesús A. ; Hernández, María ; Mejorano‐Fonseca, Julián A. ; Cuervo, Claudia ; Faccini‐Martínez, Álvaro A. ; Hidalgo, Marylin ; Pérez‐Torres, Jairo ; Silva‐Ramos, Carlos Ramiro</creatorcontrib><description>Introduction
Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as Leptospira. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. Leptospira has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.
Aim
The aim of the present study was to determine the genetic diversity of Leptospira spp. harboured by bats worldwide.
Methods
A systematic review was conducted on four databases to retrieve studies in which Leptospira was detected from bats. All studies were screened to retrieve all available Leptospira spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of Leptospira species and analysed through phylogenetic analysis.
Results
A total of 418 Leptospira spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic Leptospira spp. were identified, three of them composed exclusively of sequences obtained from bats.
Conclusion
We identified that bats harbour a great genetic diversity of Leptospira spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis‐associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic Leptospira spp.</description><identifier>ISSN: 1863-1959</identifier><identifier>ISSN: 1863-2378</identifier><identifier>EISSN: 1863-2378</identifier><identifier>DOI: 10.1111/zph.13126</identifier><identifier>PMID: 38509439</identifier><language>eng</language><publisher>Germany: Blackwell Publishing Ltd</publisher><subject>Animals ; Associated species ; Bats ; bat‐borne leptospires ; Biodiversity ; Chiroptera ; Chiroptera - microbiology ; Disease Reservoirs - microbiology ; Disease Reservoirs - veterinary ; genetic databases ; Genetic diversity ; Genetic Variation ; Introduced species ; Leptospira ; Leptospira - classification ; Leptospira - genetics ; Leptospira - isolation & purification ; Leptospirosis ; Leptospirosis - epidemiology ; Leptospirosis - microbiology ; Leptospirosis - veterinary ; Nucleotide sequence ; Pathogens ; phylogenetic analysis ; Phylogenetics ; Phylogeny ; public health ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; saprophytes ; species ; systematic review ; Zoonoses</subject><ispartof>Zoonoses and public health, 2024-08, Vol.71 (5), p.457-468</ispartof><rights>2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd</rights><rights>2024 Wiley‐VCH GmbH. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2024 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3466-839bfad2a0f554124e14a3cf7e8a1f7ed6cc2966fe30f13e13fee9d269629c913</cites><orcidid>0000-0002-3494-6481 ; 0000-0001-8960-0616 ; 0000-0001-7121-6210 ; 0000-0002-1127-0132 ; 0000-0003-0669-494X ; 0000-0001-7993-1198 ; 0000-0001-7715-8541 ; 0009-0006-5428-264X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fzph.13126$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fzph.13126$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38509439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matiz‐González, J. Manuel</creatorcontrib><creatorcontrib>Ballesteros‐Ballesteros, Jesús A.</creatorcontrib><creatorcontrib>Hernández, María</creatorcontrib><creatorcontrib>Mejorano‐Fonseca, Julián A.</creatorcontrib><creatorcontrib>Cuervo, Claudia</creatorcontrib><creatorcontrib>Faccini‐Martínez, Álvaro A.</creatorcontrib><creatorcontrib>Hidalgo, Marylin</creatorcontrib><creatorcontrib>Pérez‐Torres, Jairo</creatorcontrib><creatorcontrib>Silva‐Ramos, Carlos Ramiro</creatorcontrib><title>Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide</title><title>Zoonoses and public health</title><addtitle>Zoonoses Public Health</addtitle><description>Introduction
Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as Leptospira. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. Leptospira has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.
Aim
The aim of the present study was to determine the genetic diversity of Leptospira spp. harboured by bats worldwide.
Methods
A systematic review was conducted on four databases to retrieve studies in which Leptospira was detected from bats. All studies were screened to retrieve all available Leptospira spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of Leptospira species and analysed through phylogenetic analysis.
Results
A total of 418 Leptospira spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic Leptospira spp. were identified, three of them composed exclusively of sequences obtained from bats.
Conclusion
We identified that bats harbour a great genetic diversity of Leptospira spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis‐associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic Leptospira spp.</description><subject>Animals</subject><subject>Associated species</subject><subject>Bats</subject><subject>bat‐borne leptospires</subject><subject>Biodiversity</subject><subject>Chiroptera</subject><subject>Chiroptera - microbiology</subject><subject>Disease Reservoirs - microbiology</subject><subject>Disease Reservoirs - veterinary</subject><subject>genetic databases</subject><subject>Genetic diversity</subject><subject>Genetic Variation</subject><subject>Introduced species</subject><subject>Leptospira</subject><subject>Leptospira - classification</subject><subject>Leptospira - genetics</subject><subject>Leptospira - isolation & purification</subject><subject>Leptospirosis</subject><subject>Leptospirosis - epidemiology</subject><subject>Leptospirosis - microbiology</subject><subject>Leptospirosis - veterinary</subject><subject>Nucleotide sequence</subject><subject>Pathogens</subject><subject>phylogenetic analysis</subject><subject>Phylogenetics</subject><subject>Phylogeny</subject><subject>public health</subject><subject>RNA, Ribosomal, 16S - genetics</subject><subject>rRNA 16S</subject><subject>saprophytes</subject><subject>species</subject><subject>systematic review</subject><subject>Zoonoses</subject><issn>1863-1959</issn><issn>1863-2378</issn><issn>1863-2378</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0UFLwzAYBuAgitPpwT8gBS962Jb0a9PmKKJOGLqDXryELP3iMrqlJp1j_nqjmx4EMYckkIcXvryEnDDaZ3EN3ptpnwFL-Q45YCWHXgpFubu9M5GLDjkMYUZpngta7JMOlDkVGYgDcn-LC2ytTir7hj7Ydp04k4zZoFHt1L3gIj6NsGldaKxXSWhQWwzJ1IUWq2SyTiaqDcnK-bpa2QqPyJ5RdcDj7dklTzfXj1fD3ujh9u7qctTTkHHeK0FMjKpSRU2eZyzNkGUKtCmwVCzuFdc6FZwbBGoYIAODKKqUC54KLRh0yfkmt_HudYmhlXMbNNa1WqBbBgksB85FET_gP5qKAhiNPov07BeduaVfxEEk0ALKMiuEiOpio7R3IXg0svF2rvxaMio_-5CxD_nVR7Sn28TlZI7Vj_wuIILBBqxsjeu_k-TzeLiJ_ABAYZOD</recordid><startdate>202408</startdate><enddate>202408</enddate><creator>Matiz‐González, J. Manuel</creator><creator>Ballesteros‐Ballesteros, Jesús A.</creator><creator>Hernández, María</creator><creator>Mejorano‐Fonseca, Julián A.</creator><creator>Cuervo, Claudia</creator><creator>Faccini‐Martínez, Álvaro A.</creator><creator>Hidalgo, Marylin</creator><creator>Pérez‐Torres, Jairo</creator><creator>Silva‐Ramos, Carlos Ramiro</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>F1W</scope><scope>H94</scope><scope>H95</scope><scope>K9.</scope><scope>L.G</scope><scope>M7N</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-3494-6481</orcidid><orcidid>https://orcid.org/0000-0001-8960-0616</orcidid><orcidid>https://orcid.org/0000-0001-7121-6210</orcidid><orcidid>https://orcid.org/0000-0002-1127-0132</orcidid><orcidid>https://orcid.org/0000-0003-0669-494X</orcidid><orcidid>https://orcid.org/0000-0001-7993-1198</orcidid><orcidid>https://orcid.org/0000-0001-7715-8541</orcidid><orcidid>https://orcid.org/0009-0006-5428-264X</orcidid></search><sort><creationdate>202408</creationdate><title>Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide</title><author>Matiz‐González, J. Manuel ; Ballesteros‐Ballesteros, Jesús A. ; Hernández, María ; Mejorano‐Fonseca, Julián A. ; Cuervo, Claudia ; Faccini‐Martínez, Álvaro A. ; Hidalgo, Marylin ; Pérez‐Torres, Jairo ; Silva‐Ramos, Carlos Ramiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3466-839bfad2a0f554124e14a3cf7e8a1f7ed6cc2966fe30f13e13fee9d269629c913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Associated species</topic><topic>Bats</topic><topic>bat‐borne leptospires</topic><topic>Biodiversity</topic><topic>Chiroptera</topic><topic>Chiroptera - microbiology</topic><topic>Disease Reservoirs - microbiology</topic><topic>Disease Reservoirs - veterinary</topic><topic>genetic databases</topic><topic>Genetic diversity</topic><topic>Genetic Variation</topic><topic>Introduced species</topic><topic>Leptospira</topic><topic>Leptospira - classification</topic><topic>Leptospira - genetics</topic><topic>Leptospira - isolation & purification</topic><topic>Leptospirosis</topic><topic>Leptospirosis - epidemiology</topic><topic>Leptospirosis - microbiology</topic><topic>Leptospirosis - veterinary</topic><topic>Nucleotide sequence</topic><topic>Pathogens</topic><topic>phylogenetic analysis</topic><topic>Phylogenetics</topic><topic>Phylogeny</topic><topic>public health</topic><topic>RNA, Ribosomal, 16S - genetics</topic><topic>rRNA 16S</topic><topic>saprophytes</topic><topic>species</topic><topic>systematic review</topic><topic>Zoonoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matiz‐González, J. Manuel</creatorcontrib><creatorcontrib>Ballesteros‐Ballesteros, Jesús A.</creatorcontrib><creatorcontrib>Hernández, María</creatorcontrib><creatorcontrib>Mejorano‐Fonseca, Julián A.</creatorcontrib><creatorcontrib>Cuervo, Claudia</creatorcontrib><creatorcontrib>Faccini‐Martínez, Álvaro A.</creatorcontrib><creatorcontrib>Hidalgo, Marylin</creatorcontrib><creatorcontrib>Pérez‐Torres, Jairo</creatorcontrib><creatorcontrib>Silva‐Ramos, Carlos Ramiro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ASFA: Aquatic Sciences and Fisheries Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) 1: Biological Sciences & Living Resources</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Aquatic Science & Fisheries Abstracts (ASFA) Professional</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Zoonoses and public health</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matiz‐González, J. Manuel</au><au>Ballesteros‐Ballesteros, Jesús A.</au><au>Hernández, María</au><au>Mejorano‐Fonseca, Julián A.</au><au>Cuervo, Claudia</au><au>Faccini‐Martínez, Álvaro A.</au><au>Hidalgo, Marylin</au><au>Pérez‐Torres, Jairo</au><au>Silva‐Ramos, Carlos Ramiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide</atitle><jtitle>Zoonoses and public health</jtitle><addtitle>Zoonoses Public Health</addtitle><date>2024-08</date><risdate>2024</risdate><volume>71</volume><issue>5</issue><spage>457</spage><epage>468</epage><pages>457-468</pages><issn>1863-1959</issn><issn>1863-2378</issn><eissn>1863-2378</eissn><abstract>Introduction
Bats are a diverse group of mammals that have unique features allowing them to act as reservoir hosts for several zoonotic pathogens such as Leptospira. Leptospires have been classified into pathogenic, intermediate, and saprophytic groups and more recently into clades P1, P2, S1, and S2, being all the most important pathogenic species related to leptospirosis included within the P1/pathogenic clade. Leptospira has been detected from bats in several regions worldwide; however, the diversity of leptospires harboured by bats is still unknown.
Aim
The aim of the present study was to determine the genetic diversity of Leptospira spp. harboured by bats worldwide.
Methods
A systematic review was conducted on four databases to retrieve studies in which Leptospira was detected from bats. All studies were screened to retrieve all available Leptospira spp. 16S rRNA sequences from the GenBank database and data regarding their origin. Sequences obtained were compared with each other and reference sequences of Leptospira species and analysed through phylogenetic analysis.
Results
A total of 418 Leptospira spp. 16S rRNA sequences isolated from 55 bat species from 14 countries were retrieved from 15 selected manuscripts. From these, 417 sequences clustered within the P1/pathogenic group, and only one sequence clustered within the P2/intermediate group. Six major clades of P1/pathogenic Leptospira spp. were identified, three of them composed exclusively of sequences obtained from bats.
Conclusion
We identified that bats harbour a great genetic diversity of Leptospira spp. that form part of the P1/pathogenic clade, some of which are closely related to leptospirosis‐associated species. This finding contributes to the knowledge of the diversity of leptospires hosted by bats worldwide and reinforces the role of bats as reservoirs of P1/pathogenic Leptospira spp.</abstract><cop>Germany</cop><pub>Blackwell Publishing Ltd</pub><pmid>38509439</pmid><doi>10.1111/zph.13126</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-3494-6481</orcidid><orcidid>https://orcid.org/0000-0001-8960-0616</orcidid><orcidid>https://orcid.org/0000-0001-7121-6210</orcidid><orcidid>https://orcid.org/0000-0002-1127-0132</orcidid><orcidid>https://orcid.org/0000-0003-0669-494X</orcidid><orcidid>https://orcid.org/0000-0001-7993-1198</orcidid><orcidid>https://orcid.org/0000-0001-7715-8541</orcidid><orcidid>https://orcid.org/0009-0006-5428-264X</orcidid></addata></record> |
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| ispartof | Zoonoses and public health, 2024-08, Vol.71 (5), p.457-468 |
| issn | 1863-1959 1863-2378 1863-2378 |
| language | eng |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Animals Associated species Bats bat‐borne leptospires Biodiversity Chiroptera Chiroptera - microbiology Disease Reservoirs - microbiology Disease Reservoirs - veterinary genetic databases Genetic diversity Genetic Variation Introduced species Leptospira Leptospira - classification Leptospira - genetics Leptospira - isolation & purification Leptospirosis Leptospirosis - epidemiology Leptospirosis - microbiology Leptospirosis - veterinary Nucleotide sequence Pathogens phylogenetic analysis Phylogenetics Phylogeny public health RNA, Ribosomal, 16S - genetics rRNA 16S saprophytes species systematic review Zoonoses |
| title | Genetic diversity of P1/pathogenic Leptospira species hosted by bats worldwide |
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