Diabetes and Infectious Diseases with a Focus on Melioidosis
Diabetes mellitus (DM) leads to impaired innate and adaptive immune responses. This renders individuals with DM highly susceptible to microbial infections such as COVID-19, tuberculosis and melioidosis. Melioidosis is a tropical disease caused by the bacterial pathogen Burkholderia pseudomallei , wh...
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| Veröffentlicht in: | Current microbiology 2024-07, Vol.81 (7), p.208-208, Article 208 |
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| creator | Uthaya Kumar, Asqwin Ahmad Zan, Muhammad Ng, Chyan-Leong Chieng, Sylvia Nathan, Sheila |
| description | Diabetes mellitus (DM) leads to impaired innate and adaptive immune responses. This renders individuals with DM highly susceptible to microbial infections such as COVID-19, tuberculosis and melioidosis. Melioidosis is a tropical disease caused by the bacterial pathogen
Burkholderia pseudomallei
, where diabetes is consistently reported as the most significant risk factor associated with the disease. Type-2 diabetes is observed in 39% of melioidosis patients where the risk of infection is 13-fold higher than non-diabetic individuals.
B. pseudomallei
is found in the environment and is an opportunistic pathogen in humans, often exhibiting severe clinical manifestations in immunocompromised patients. The pathophysiology of diabetes significantly affects the host immune responses that play a critical role in fighting the infection, such as leukocyte and neutrophil impairment, macrophage and monocyte inhibition and natural killer cell dysfunction. These defects result in delayed recruitment as well as activation of immune cells to target the invading
B. pseudomallei
. This provides an advantage for the pathogen to survive and adapt within the immunocompromised diabetic patients. Nevertheless, knowledge gaps on diabetes-infectious disease comorbidity, in particular, melioidosis-diabetes comorbidity, need to be filled to fully understand the dysfunctional host immune responses and adaptation of the pathogen under diabetic conditions to guide therapeutic options. |
| doi_str_mv | 10.1007/s00284-024-03748-z |
| format | Article |
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Burkholderia pseudomallei
, where diabetes is consistently reported as the most significant risk factor associated with the disease. Type-2 diabetes is observed in 39% of melioidosis patients where the risk of infection is 13-fold higher than non-diabetic individuals.
B. pseudomallei
is found in the environment and is an opportunistic pathogen in humans, often exhibiting severe clinical manifestations in immunocompromised patients. The pathophysiology of diabetes significantly affects the host immune responses that play a critical role in fighting the infection, such as leukocyte and neutrophil impairment, macrophage and monocyte inhibition and natural killer cell dysfunction. These defects result in delayed recruitment as well as activation of immune cells to target the invading
B. pseudomallei
. This provides an advantage for the pathogen to survive and adapt within the immunocompromised diabetic patients. Nevertheless, knowledge gaps on diabetes-infectious disease comorbidity, in particular, melioidosis-diabetes comorbidity, need to be filled to fully understand the dysfunctional host immune responses and adaptation of the pathogen under diabetic conditions to guide therapeutic options.</description><identifier>ISSN: 0343-8651</identifier><identifier>ISSN: 1432-0991</identifier><identifier>EISSN: 1432-0991</identifier><identifier>DOI: 10.1007/s00284-024-03748-z</identifier><identifier>PMID: 38833191</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Biomedical and Life Sciences ; Biotechnology ; Burkholderia pseudomallei ; Burkholderia pseudomallei - immunology ; Cell activation ; Comorbidity ; COVID-19 ; COVID-19 infection ; Diabetes ; Diabetes Complications - microbiology ; Diabetes mellitus ; Diabetes Mellitus - immunology ; Diabetes Mellitus - microbiology ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - immunology ; Diabetes Mellitus, Type 2 - microbiology ; Health risks ; Humans ; Immune response ; Immune system ; Immunocompromised Host ; Immunocompromised hosts ; Infectious diseases ; Leukocytes (neutrophilic) ; Life Sciences ; Macrophages ; Melioidosis ; Melioidosis - immunology ; Melioidosis - microbiology ; Microbiology ; Microorganisms ; Monocytes ; Natural killer cells ; neutrophils ; noninsulin-dependent diabetes mellitus ; Opportunist infection ; opportunistic pathogens ; Pathogens ; Pathophysiology ; Review Article ; Risk factors ; therapeutics ; tropical diseases ; tuberculosis</subject><ispartof>Current microbiology, 2024-07, Vol.81 (7), p.208-208, Article 208</ispartof><rights>The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-d9ee7c08182c85d8107af63ffcccc1082c1b7a51917300084216d03cca65d63</cites><orcidid>0000-0002-2132-2346</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00284-024-03748-z$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00284-024-03748-z$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38833191$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Uthaya Kumar, Asqwin</creatorcontrib><creatorcontrib>Ahmad Zan, Muhammad</creatorcontrib><creatorcontrib>Ng, Chyan-Leong</creatorcontrib><creatorcontrib>Chieng, Sylvia</creatorcontrib><creatorcontrib>Nathan, Sheila</creatorcontrib><title>Diabetes and Infectious Diseases with a Focus on Melioidosis</title><title>Current microbiology</title><addtitle>Curr Microbiol</addtitle><addtitle>Curr Microbiol</addtitle><description>Diabetes mellitus (DM) leads to impaired innate and adaptive immune responses. This renders individuals with DM highly susceptible to microbial infections such as COVID-19, tuberculosis and melioidosis. Melioidosis is a tropical disease caused by the bacterial pathogen
Burkholderia pseudomallei
, where diabetes is consistently reported as the most significant risk factor associated with the disease. Type-2 diabetes is observed in 39% of melioidosis patients where the risk of infection is 13-fold higher than non-diabetic individuals.
B. pseudomallei
is found in the environment and is an opportunistic pathogen in humans, often exhibiting severe clinical manifestations in immunocompromised patients. The pathophysiology of diabetes significantly affects the host immune responses that play a critical role in fighting the infection, such as leukocyte and neutrophil impairment, macrophage and monocyte inhibition and natural killer cell dysfunction. These defects result in delayed recruitment as well as activation of immune cells to target the invading
B. pseudomallei
. This provides an advantage for the pathogen to survive and adapt within the immunocompromised diabetic patients. Nevertheless, knowledge gaps on diabetes-infectious disease comorbidity, in particular, melioidosis-diabetes comorbidity, need to be filled to fully understand the dysfunctional host immune responses and adaptation of the pathogen under diabetic conditions to guide therapeutic options.</description><subject>Biomedical and Life Sciences</subject><subject>Biotechnology</subject><subject>Burkholderia pseudomallei</subject><subject>Burkholderia pseudomallei - immunology</subject><subject>Cell activation</subject><subject>Comorbidity</subject><subject>COVID-19</subject><subject>COVID-19 infection</subject><subject>Diabetes</subject><subject>Diabetes Complications - microbiology</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus - immunology</subject><subject>Diabetes Mellitus - microbiology</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - immunology</subject><subject>Diabetes Mellitus, Type 2 - microbiology</subject><subject>Health risks</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunocompromised Host</subject><subject>Immunocompromised hosts</subject><subject>Infectious diseases</subject><subject>Leukocytes (neutrophilic)</subject><subject>Life Sciences</subject><subject>Macrophages</subject><subject>Melioidosis</subject><subject>Melioidosis - immunology</subject><subject>Melioidosis - microbiology</subject><subject>Microbiology</subject><subject>Microorganisms</subject><subject>Monocytes</subject><subject>Natural killer cells</subject><subject>neutrophils</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Opportunist infection</subject><subject>opportunistic pathogens</subject><subject>Pathogens</subject><subject>Pathophysiology</subject><subject>Review Article</subject><subject>Risk factors</subject><subject>therapeutics</subject><subject>tropical diseases</subject><subject>tuberculosis</subject><issn>0343-8651</issn><issn>1432-0991</issn><issn>1432-0991</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkV9LwzAUxYMobv75Aj5IwRdfqje9bZKCL7I5HUx80PeQpalmdM1sWsR9euM6FXzQQAic_O7JzT2EnFC4oAD80gMkIo0hCRt5KuL1DhnSFJMY8pzukiFgirFgGR2QA-8XADTJge6TAQqBSHM6JFdjq-amNT5SdRFN69Lo1rrOR2PrjfJBf7PtS6SiidNBdXV0byrrbOG89Udkr1SVN8fb85A8Tm6eRnfx7OF2OrqexRqzvI2L3BiuQVCRaJEVggJXJcOy1GFRCCqdc5WFfjgCgEgTygpArRXLCoaH5Lx3XTXutTO-lUvrtakqVZvQqUSaIWOCseR_FFiaiTCiLKBnv9CF65o6fGNDIeeY8kAlPaUb531jSrlq7FI175KC_AxB9iHIEILchCDXoeh0a93Nl6b4LvmaegCwB3y4qp9N8_P2H7YfoGqP6w</recordid><startdate>20240701</startdate><enddate>20240701</enddate><creator>Uthaya Kumar, Asqwin</creator><creator>Ahmad Zan, Muhammad</creator><creator>Ng, Chyan-Leong</creator><creator>Chieng, Sylvia</creator><creator>Nathan, Sheila</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-2132-2346</orcidid></search><sort><creationdate>20240701</creationdate><title>Diabetes and Infectious Diseases with a Focus on Melioidosis</title><author>Uthaya Kumar, Asqwin ; Ahmad Zan, Muhammad ; Ng, Chyan-Leong ; Chieng, Sylvia ; Nathan, Sheila</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-d9ee7c08182c85d8107af63ffcccc1082c1b7a51917300084216d03cca65d63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biomedical and Life Sciences</topic><topic>Biotechnology</topic><topic>Burkholderia pseudomallei</topic><topic>Burkholderia pseudomallei - immunology</topic><topic>Cell activation</topic><topic>Comorbidity</topic><topic>COVID-19</topic><topic>COVID-19 infection</topic><topic>Diabetes</topic><topic>Diabetes Complications - microbiology</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus - immunology</topic><topic>Diabetes Mellitus - microbiology</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - immunology</topic><topic>Diabetes Mellitus, Type 2 - microbiology</topic><topic>Health risks</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunocompromised Host</topic><topic>Immunocompromised hosts</topic><topic>Infectious diseases</topic><topic>Leukocytes (neutrophilic)</topic><topic>Life Sciences</topic><topic>Macrophages</topic><topic>Melioidosis</topic><topic>Melioidosis - immunology</topic><topic>Melioidosis - microbiology</topic><topic>Microbiology</topic><topic>Microorganisms</topic><topic>Monocytes</topic><topic>Natural killer cells</topic><topic>neutrophils</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Opportunist infection</topic><topic>opportunistic pathogens</topic><topic>Pathogens</topic><topic>Pathophysiology</topic><topic>Review Article</topic><topic>Risk factors</topic><topic>therapeutics</topic><topic>tropical diseases</topic><topic>tuberculosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Uthaya Kumar, Asqwin</creatorcontrib><creatorcontrib>Ahmad Zan, Muhammad</creatorcontrib><creatorcontrib>Ng, Chyan-Leong</creatorcontrib><creatorcontrib>Chieng, Sylvia</creatorcontrib><creatorcontrib>Nathan, Sheila</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Current microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Uthaya Kumar, Asqwin</au><au>Ahmad Zan, Muhammad</au><au>Ng, Chyan-Leong</au><au>Chieng, Sylvia</au><au>Nathan, Sheila</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diabetes and Infectious Diseases with a Focus on Melioidosis</atitle><jtitle>Current microbiology</jtitle><stitle>Curr Microbiol</stitle><addtitle>Curr Microbiol</addtitle><date>2024-07-01</date><risdate>2024</risdate><volume>81</volume><issue>7</issue><spage>208</spage><epage>208</epage><pages>208-208</pages><artnum>208</artnum><issn>0343-8651</issn><issn>1432-0991</issn><eissn>1432-0991</eissn><abstract>Diabetes mellitus (DM) leads to impaired innate and adaptive immune responses. This renders individuals with DM highly susceptible to microbial infections such as COVID-19, tuberculosis and melioidosis. Melioidosis is a tropical disease caused by the bacterial pathogen
Burkholderia pseudomallei
, where diabetes is consistently reported as the most significant risk factor associated with the disease. Type-2 diabetes is observed in 39% of melioidosis patients where the risk of infection is 13-fold higher than non-diabetic individuals.
B. pseudomallei
is found in the environment and is an opportunistic pathogen in humans, often exhibiting severe clinical manifestations in immunocompromised patients. The pathophysiology of diabetes significantly affects the host immune responses that play a critical role in fighting the infection, such as leukocyte and neutrophil impairment, macrophage and monocyte inhibition and natural killer cell dysfunction. These defects result in delayed recruitment as well as activation of immune cells to target the invading
B. pseudomallei
. This provides an advantage for the pathogen to survive and adapt within the immunocompromised diabetic patients. Nevertheless, knowledge gaps on diabetes-infectious disease comorbidity, in particular, melioidosis-diabetes comorbidity, need to be filled to fully understand the dysfunctional host immune responses and adaptation of the pathogen under diabetic conditions to guide therapeutic options.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38833191</pmid><doi>10.1007/s00284-024-03748-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-2132-2346</orcidid></addata></record> |
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| subjects | Biomedical and Life Sciences Biotechnology Burkholderia pseudomallei Burkholderia pseudomallei - immunology Cell activation Comorbidity COVID-19 COVID-19 infection Diabetes Diabetes Complications - microbiology Diabetes mellitus Diabetes Mellitus - immunology Diabetes Mellitus - microbiology Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - immunology Diabetes Mellitus, Type 2 - microbiology Health risks Humans Immune response Immune system Immunocompromised Host Immunocompromised hosts Infectious diseases Leukocytes (neutrophilic) Life Sciences Macrophages Melioidosis Melioidosis - immunology Melioidosis - microbiology Microbiology Microorganisms Monocytes Natural killer cells neutrophils noninsulin-dependent diabetes mellitus Opportunist infection opportunistic pathogens Pathogens Pathophysiology Review Article Risk factors therapeutics tropical diseases tuberculosis |
| title | Diabetes and Infectious Diseases with a Focus on Melioidosis |
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