Caffeine Boosts Weight-Lifting Performance in Rats: A Pilot Study
Caffeine is a well-described ergogenic aid used to enhance athletic performance. Using animal models can greatly increase our understanding of caffeine's mechanisms in performance. Here, we adapted an animal weight-lifting exercise model to demonstrate caffeine's ergogenic effect in rats....
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| Veröffentlicht in: | Nutrients 2024-06, Vol.16 (13), p.2022 |
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| creator | Pereira-Alves, Emanuel Machado-Pereira, Julia Monteiro, Anibal Costa-Cordeiro, Roberto Chandran, Vinod Jurisica, Igor Prado, Eduardo Cameron, L C |
| description | Caffeine is a well-described ergogenic aid used to enhance athletic performance. Using animal models can greatly increase our understanding of caffeine's mechanisms in performance. Here, we adapted an animal weight-lifting exercise model to demonstrate caffeine's ergogenic effect in rats. Male Wistar rats (315 ± 35 g) were randomly divided into two groups: one group received 5 mg·kg
of caffeine (0.5 mL; CEx; n = 5) and the other 0.9% NaCl (0.5 mL; PEx; n = 4) through an orogastric probe (gavage) one hour before exercise. Weight-lifting exercise sessions were performed over three subsequent days, and the number of complete squats performed was counted. Analyses of the area under the curve in all three experiments showed that the CEx group responded more to stimuli, performing more squats (1.7-, 2.0-, and 1.6-fold;
< 0.05) than the control group did. These three days' data were analyzed to better understand the cumulative effect of this exercise, and a hyperbolic curve was fitted to these data. Data fitting from the caffeine-supplemented group, CEx, also showed larger S
and K
(2.3-fold and 1.6-fold, respectively) than the PEx group did. Our study demonstrated an acute ergogenic effect of caffeine in an animal weight-lifting exercise model for the first time, suggesting potential avenues for future research. |
| doi_str_mv | 10.3390/nu16132022 |
| format | Article |
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of caffeine (0.5 mL; CEx; n = 5) and the other 0.9% NaCl (0.5 mL; PEx; n = 4) through an orogastric probe (gavage) one hour before exercise. Weight-lifting exercise sessions were performed over three subsequent days, and the number of complete squats performed was counted. Analyses of the area under the curve in all three experiments showed that the CEx group responded more to stimuli, performing more squats (1.7-, 2.0-, and 1.6-fold;
< 0.05) than the control group did. These three days' data were analyzed to better understand the cumulative effect of this exercise, and a hyperbolic curve was fitted to these data. Data fitting from the caffeine-supplemented group, CEx, also showed larger S
and K
(2.3-fold and 1.6-fold, respectively) than the PEx group did. Our study demonstrated an acute ergogenic effect of caffeine in an animal weight-lifting exercise model for the first time, suggesting potential avenues for future research.</description><identifier>ISSN: 2072-6643</identifier><identifier>EISSN: 2072-6643</identifier><identifier>DOI: 10.3390/nu16132022</identifier><identifier>PMID: 38999769</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Adenosine ; Animals ; athletic performance ; Caffeine ; Caffeine - administration & dosage ; Caffeine - pharmacology ; Chronic illnesses ; Coffee ; Ergogenic aids ; Exercise ; Male ; males ; Performance-Enhancing Substances - administration & dosage ; Performance-Enhancing Substances - pharmacology ; Physical Conditioning, Animal - physiology ; Physiological aspects ; Pilot Projects ; Rats ; Rats, Wistar ; Software ; Testing ; Weight lifting (Sports) ; Weight Lifting - physiology</subject><ispartof>Nutrients, 2024-06, Vol.16 (13), p.2022</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c312t-ed3ca72d6e3a1edea9446e10f119b17e4e9b4ce601f00daa0a80523c46124f73</cites><orcidid>0009-0000-7882-3187 ; 0009-0007-9453-5952 ; 0009-0007-0529-0712 ; 0000-0003-4180-2061</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38999769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pereira-Alves, Emanuel</creatorcontrib><creatorcontrib>Machado-Pereira, Julia</creatorcontrib><creatorcontrib>Monteiro, Anibal</creatorcontrib><creatorcontrib>Costa-Cordeiro, Roberto</creatorcontrib><creatorcontrib>Chandran, Vinod</creatorcontrib><creatorcontrib>Jurisica, Igor</creatorcontrib><creatorcontrib>Prado, Eduardo</creatorcontrib><creatorcontrib>Cameron, L C</creatorcontrib><title>Caffeine Boosts Weight-Lifting Performance in Rats: A Pilot Study</title><title>Nutrients</title><addtitle>Nutrients</addtitle><description>Caffeine is a well-described ergogenic aid used to enhance athletic performance. Using animal models can greatly increase our understanding of caffeine's mechanisms in performance. Here, we adapted an animal weight-lifting exercise model to demonstrate caffeine's ergogenic effect in rats. Male Wistar rats (315 ± 35 g) were randomly divided into two groups: one group received 5 mg·kg
of caffeine (0.5 mL; CEx; n = 5) and the other 0.9% NaCl (0.5 mL; PEx; n = 4) through an orogastric probe (gavage) one hour before exercise. Weight-lifting exercise sessions were performed over three subsequent days, and the number of complete squats performed was counted. Analyses of the area under the curve in all three experiments showed that the CEx group responded more to stimuli, performing more squats (1.7-, 2.0-, and 1.6-fold;
< 0.05) than the control group did. These three days' data were analyzed to better understand the cumulative effect of this exercise, and a hyperbolic curve was fitted to these data. Data fitting from the caffeine-supplemented group, CEx, also showed larger S
and K
(2.3-fold and 1.6-fold, respectively) than the PEx group did. Our study demonstrated an acute ergogenic effect of caffeine in an animal weight-lifting exercise model for the first time, suggesting potential avenues for future research.</description><subject>Adenosine</subject><subject>Animals</subject><subject>athletic performance</subject><subject>Caffeine</subject><subject>Caffeine - administration & dosage</subject><subject>Caffeine - pharmacology</subject><subject>Chronic illnesses</subject><subject>Coffee</subject><subject>Ergogenic aids</subject><subject>Exercise</subject><subject>Male</subject><subject>males</subject><subject>Performance-Enhancing Substances - administration & dosage</subject><subject>Performance-Enhancing Substances - pharmacology</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Physiological aspects</subject><subject>Pilot Projects</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Software</subject><subject>Testing</subject><subject>Weight lifting (Sports)</subject><subject>Weight Lifting - physiology</subject><issn>2072-6643</issn><issn>2072-6643</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkU1LJDEQhsOirDJ62R-wNOxFhNYklUk6exuH1RUGFFfYY5NJV2Yj3Ykm6cP8e9sd9wMvVh2qKJ4q3uIl5BOjZwCanoeRSQaccv6BHHKqeC2lgL3_-gNynPMDfQlFlYSP5AAarbWS-pAslsY59AGrixhzydVP9JtfpV55V3zYVLeYXEyDCRYrH6o7U_LXalHd-j6W6kcZu-0R2Xemz3j8Wmfk_vLb_fJ7vbq5ul4uVrUFxkuNHVijeCcRDMMOjRZCIqOOMb1mCgXqtbAoKXOUdsZQ09A5Bysk48IpmJGT3dnHFJ9GzKUdfLbY9yZgHHMLbA5yYuf6fZQq3cwb3jQT-uUN-hDHFKY_flMMlJhEzMjZjtqYHlsfXCzJ2Ck7HLyNAZ2f5ouGMhCyATotnO4WbIo5J3TtY_KDSduW0fbFtvafbRP8-VXDuB6w-4v-MQmeAewKjs0</recordid><startdate>20240626</startdate><enddate>20240626</enddate><creator>Pereira-Alves, Emanuel</creator><creator>Machado-Pereira, Julia</creator><creator>Monteiro, Anibal</creator><creator>Costa-Cordeiro, Roberto</creator><creator>Chandran, Vinod</creator><creator>Jurisica, Igor</creator><creator>Prado, Eduardo</creator><creator>Cameron, L C</creator><general>MDPI AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0000-7882-3187</orcidid><orcidid>https://orcid.org/0009-0007-9453-5952</orcidid><orcidid>https://orcid.org/0009-0007-0529-0712</orcidid><orcidid>https://orcid.org/0000-0003-4180-2061</orcidid></search><sort><creationdate>20240626</creationdate><title>Caffeine Boosts Weight-Lifting Performance in Rats: A Pilot Study</title><author>Pereira-Alves, Emanuel ; 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Using animal models can greatly increase our understanding of caffeine's mechanisms in performance. Here, we adapted an animal weight-lifting exercise model to demonstrate caffeine's ergogenic effect in rats. Male Wistar rats (315 ± 35 g) were randomly divided into two groups: one group received 5 mg·kg
of caffeine (0.5 mL; CEx; n = 5) and the other 0.9% NaCl (0.5 mL; PEx; n = 4) through an orogastric probe (gavage) one hour before exercise. Weight-lifting exercise sessions were performed over three subsequent days, and the number of complete squats performed was counted. Analyses of the area under the curve in all three experiments showed that the CEx group responded more to stimuli, performing more squats (1.7-, 2.0-, and 1.6-fold;
< 0.05) than the control group did. These three days' data were analyzed to better understand the cumulative effect of this exercise, and a hyperbolic curve was fitted to these data. Data fitting from the caffeine-supplemented group, CEx, also showed larger S
and K
(2.3-fold and 1.6-fold, respectively) than the PEx group did. Our study demonstrated an acute ergogenic effect of caffeine in an animal weight-lifting exercise model for the first time, suggesting potential avenues for future research.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>38999769</pmid><doi>10.3390/nu16132022</doi><orcidid>https://orcid.org/0009-0000-7882-3187</orcidid><orcidid>https://orcid.org/0009-0007-9453-5952</orcidid><orcidid>https://orcid.org/0009-0007-0529-0712</orcidid><orcidid>https://orcid.org/0000-0003-4180-2061</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Adenosine Animals athletic performance Caffeine Caffeine - administration & dosage Caffeine - pharmacology Chronic illnesses Coffee Ergogenic aids Exercise Male males Performance-Enhancing Substances - administration & dosage Performance-Enhancing Substances - pharmacology Physical Conditioning, Animal - physiology Physiological aspects Pilot Projects Rats Rats, Wistar Software Testing Weight lifting (Sports) Weight Lifting - physiology |
| title | Caffeine Boosts Weight-Lifting Performance in Rats: A Pilot Study |
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