Antagonism of androgen receptor signaling by aloe-emodin

Over the past decades, androgen receptor (AR) signaling has been a key driver of both primary and recurrent prostate cancer. In this work, aloe-emodin was identified as a novel AR antagonist, effectively inhibiting AR signaling. Firstly, aloe-emodin can inhibit LNCaP cell growth by promoting apoptos...

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Veröffentlicht in:	Food and chemical toxicology 2023-11, Vol.181, p.114092-114092, Article 114092
Hauptverfasser:	Zhao, Jingqi, Sun, Yantong, Ren, Li, Huang, Shuqing, Zhang, Jie
Format:	Artikel
Sprache:	eng
Schlagworte:	Aloe-emodin Androgen receptor androgen receptors antagonism Antagonist antagonists Anti-prostate cancer apoptosis cell growth cytoplasm fluorescent antibody technique ligands molecular dynamics prostatic neoplasms quantitative polymerase chain reaction toxicology Western blotting
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