Therapeutic effects of OXY- ExoAloe in diabetic wound injury

Delayed wound healing are common complications for diabetic patients. In light of chronic hypoxia's delay in wound healing, it is hypothesized that providing a better oxygen environment at the wound site will promote diabetic wound healing. OXY-ExoAloe is an innovative and effective therapy prepared from exosome-like vesicles of aloe vera gel, ginger juice and neem fruit sap. A combination of three herbal, oxygen-delivering and medicinally valued plants was standardized to determine if the combination had the desired effect. Interestingly, when we used OXY-ExoAloe at a particular ratio on a diabetic wound, the herbal therapy speeded up wound healing by reducing swelling, and the severity of the wound. Further, our data suggests that OXY-ExoAloe promoted wound healing by increasing wound oxygenation, reducing inflammation, cytokine production, and matrix remodeling. It is also safe and effective, with no reported side effects. •Aloe vera, ginger, and neem fruit EVs combine to create OXY-ExoAloe.•OXY-ExoAloe treated diabetic wounds by oxygenating and reducing inflammation.•Diabetes rats reepithelialize more rapidly with OXY-ExoAloe, which regulates cytokines and ECM.