Rational Tuning of the Concentration-independent Enrichment of Prion-like Domains in Stress Granules

[Display omitted] •Determinants of PrLD recruitment to SGs have not been fully characterized.•Non-aromatic hydrophobic residues tune PrLD recruitment to SGs.•PrLD concentration has little or no effect on SG recruitment.•PrLDs offer a synthetic biology toolkit for tunable targeting to SGs.•PrLD recru...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular biology 2024-09, Vol.436 (18), p.168703, Article 168703
Hauptverfasser:	Baer, Matthew H., Cascarina, Sean M., Paul, Kacy R., Ross, Eric D.
Format:	Artikel
Sprache:	eng
Schlagworte:	amino acid composition biomolecular condensate Biomolecular Condensates - chemistry Biomolecular Condensates - metabolism Cytoplasmic Granules - chemistry Cytoplasmic Granules - metabolism eukaryotic cells Humans Hydrophobic and Hydrophilic Interactions hydrophobicity intrinsically disordered region liquid–liquid phase separation molecular biology prion-like domain Prions - chemistry Prions - metabolism Protein Domains ribonucleoproteins Ribonucleoproteins - chemistry Ribonucleoproteins - metabolism RNA separation solvation stress granule Stress Granules - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!