Additional mechanism for selective absorption of cholesterol and phytosterols

Phytosterols are structurally similar to cholesterol but they are much less absorbed (50%) in the intestine. We hypothesize that phytosterols are poor substrates of intestinal acyl-CoA: cholesterol acyltransferase 2 (ACAT2), and thus minimal phytosterol esters are formed and packed into chylomicrons...

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Veröffentlicht in:	Food chemistry 2024-11, Vol.458, p.140300, Article 140300
Hauptverfasser:	CHEN, Zixing, DING, Huafang, ZHU, Hanyue, HUANG, Shouhe, YAN, Chi, CHEN, Zhen-Yu
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption ACAT2 acyl coenzyme A Animals Caco-2 Caco-2 Cells campesterol Cholesterol Cholesterol - chemistry Cholesterol - metabolism cholesterol acyltransferase chylomicrons Cricetinae dose response Esterification food chemistry hamsters heart human cell lines Humans hyperlipidemia Intestinal Absorption intestines isotopes Microsome Molecular Docking Simulation Phytosterol Phytosterols - chemistry Phytosterols - metabolism sitosterols Sterol O-Acyltransferase - chemistry Sterol O-Acyltransferase - metabolism Sterol O-Acyltransferase 2 - chemistry Sterol O-Acyltransferase 2 - metabolism stigmasterol
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