Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study
The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular viability of A549 cells was investigated, and it was discovered that AVL has a considerable ne...
Gespeichert in:
| Veröffentlicht in: | In vitro cellular & developmental biology. Animal 2024-04, Vol.60 (4), p.374-381 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 381 |
|---|---|
| container_issue | 4 |
| container_start_page | 374 |
| container_title | In vitro cellular & developmental biology. Animal |
| container_volume | 60 |
| creator | Dang, Zhiguo Liu, Songbo Wang, XiaoJuan Ren, Fangfang Hussain, Shaik Althaf Jia, Dong |
| description | The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular viability of A549 cells was investigated, and it was discovered that AVL has a considerable negative impact on cellular viability. Following that, an investigation using flow cytometry was carried out to investigate its function in the process of apoptosis and the cell cycle of A549 cells. It has been discovered that AVL significantly promotes apoptosis and stops the cell cycle at the G2/M phase. The colony-forming capacity of A549 cells was observed to be greatly suppressed as the AVL concentration increased compared to the group that received no treatment. In addition to this, the benzo(a)pyrene in vivo model was established in order to investigate the pharmacological value of AVL. The findings revealed that AVL greatly prevented the formation of pro-inflammatory cytokines, in addition to the reduction in oxidative stress, which was evidenced by a reduction in the concentration of TNF-α, IL-1β, IL-6, and MDA with an improvement in the concentration of SOD and GPx, respectively. Our results successfully demonstrated the pharmacological benefit of avicularin against lung cancer, and it has been suggested that it showed a multifactorial effect. |
| doi_str_mv | 10.1007/s11626-024-00854-x |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153653492</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3051510719</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-1018d6b30b2ed30cc79d1bc1626a274f21f244289eb813b3155fc6931b220a383</originalsourceid><addsrcrecordid>eNqFkU1vFSEUhonR2Fr9Ay4MiRsXncrHwAzumsavpIkuNHFHGAauNDNwBebm9r_0x3ruhzbpQtlwDud5XwIvQi8puaCEdG8LpZLJhrC2IaQXbbN9hE6paHnTEfnjMdSkow2TipygZ6XcEFiKyqfohPdCMaHkKbr7mlN1toaNw857qHDy2GyCXSaTQ8RmZUIsFU9LXGFronUZb4LBIf4MQ6gBTkP0k5lnU0OK5zhtw2j2fqVmV8o5NnEEZlzsDtjbr9O6phLKO5jBCAxrTkcOmk0C7TLePkdPvJmKe3Hcz9D3D--_XX1qrr98_Hx1ed1YLlRtKKH9KAdOBuZGTqzt1EgHu_scw7rWM-pZ27JeuaGnfOBUCG-l4nRgjBje8zP05uC7zunX4krVcyjWTZOJLi1Fg4JLwVvF_o8SLkjHZd8C-voBepOWHOEhQAkqdukooNiBsjmVkp3X6xxmk281JXoXsz7ErCFmvY9Zb0H06mi9DLMb_0r-5AoAPwAFRnHl8v3d_7D9Dey_tKM</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3051510719</pqid></control><display><type>article</type><title>Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study</title><source>Springer Nature - Complete Springer Journals</source><creator>Dang, Zhiguo ; Liu, Songbo ; Wang, XiaoJuan ; Ren, Fangfang ; Hussain, Shaik Althaf ; Jia, Dong</creator><creatorcontrib>Dang, Zhiguo ; Liu, Songbo ; Wang, XiaoJuan ; Ren, Fangfang ; Hussain, Shaik Althaf ; Jia, Dong</creatorcontrib><description>The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular viability of A549 cells was investigated, and it was discovered that AVL has a considerable negative impact on cellular viability. Following that, an investigation using flow cytometry was carried out to investigate its function in the process of apoptosis and the cell cycle of A549 cells. It has been discovered that AVL significantly promotes apoptosis and stops the cell cycle at the G2/M phase. The colony-forming capacity of A549 cells was observed to be greatly suppressed as the AVL concentration increased compared to the group that received no treatment. In addition to this, the benzo(a)pyrene in vivo model was established in order to investigate the pharmacological value of AVL. The findings revealed that AVL greatly prevented the formation of pro-inflammatory cytokines, in addition to the reduction in oxidative stress, which was evidenced by a reduction in the concentration of TNF-α, IL-1β, IL-6, and MDA with an improvement in the concentration of SOD and GPx, respectively. Our results successfully demonstrated the pharmacological benefit of avicularin against lung cancer, and it has been suggested that it showed a multifactorial effect.</description><identifier>ISSN: 1071-2690</identifier><identifier>EISSN: 1543-706X</identifier><identifier>DOI: 10.1007/s11626-024-00854-x</identifier><identifier>PMID: 38592596</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animal Genetics and Genomics ; Anticancer properties ; Apoptosis ; Benzo(a)pyrene ; Biomedical and Life Sciences ; Cancer therapies ; Cell Biology ; Cell Culture ; Cell cycle ; Cell viability ; Developmental Biology ; Flow cytometry ; In vivo methods and tests ; Inflammation ; interleukin-6 ; Investigations ; Life Sciences ; Lung cancer ; lung neoplasms ; Oxidative stress ; Pharmacology ; protective effect ; Stem Cells ; Tumor necrosis factor-α</subject><ispartof>In vitro cellular & developmental biology. Animal, 2024-04, Vol.60 (4), p.374-381</ispartof><rights>The Society for In Vitro Biology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Society for In Vitro Biology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-1018d6b30b2ed30cc79d1bc1626a274f21f244289eb813b3155fc6931b220a383</cites><orcidid>0009-0008-6081-5590</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11626-024-00854-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11626-024-00854-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38592596$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dang, Zhiguo</creatorcontrib><creatorcontrib>Liu, Songbo</creatorcontrib><creatorcontrib>Wang, XiaoJuan</creatorcontrib><creatorcontrib>Ren, Fangfang</creatorcontrib><creatorcontrib>Hussain, Shaik Althaf</creatorcontrib><creatorcontrib>Jia, Dong</creatorcontrib><title>Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study</title><title>In vitro cellular & developmental biology. Animal</title><addtitle>In Vitro Cell.Dev.Biol.-Animal</addtitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><description>The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular viability of A549 cells was investigated, and it was discovered that AVL has a considerable negative impact on cellular viability. Following that, an investigation using flow cytometry was carried out to investigate its function in the process of apoptosis and the cell cycle of A549 cells. It has been discovered that AVL significantly promotes apoptosis and stops the cell cycle at the G2/M phase. The colony-forming capacity of A549 cells was observed to be greatly suppressed as the AVL concentration increased compared to the group that received no treatment. In addition to this, the benzo(a)pyrene in vivo model was established in order to investigate the pharmacological value of AVL. The findings revealed that AVL greatly prevented the formation of pro-inflammatory cytokines, in addition to the reduction in oxidative stress, which was evidenced by a reduction in the concentration of TNF-α, IL-1β, IL-6, and MDA with an improvement in the concentration of SOD and GPx, respectively. Our results successfully demonstrated the pharmacological benefit of avicularin against lung cancer, and it has been suggested that it showed a multifactorial effect.</description><subject>Animal Genetics and Genomics</subject><subject>Anticancer properties</subject><subject>Apoptosis</subject><subject>Benzo(a)pyrene</subject><subject>Biomedical and Life Sciences</subject><subject>Cancer therapies</subject><subject>Cell Biology</subject><subject>Cell Culture</subject><subject>Cell cycle</subject><subject>Cell viability</subject><subject>Developmental Biology</subject><subject>Flow cytometry</subject><subject>In vivo methods and tests</subject><subject>Inflammation</subject><subject>interleukin-6</subject><subject>Investigations</subject><subject>Life Sciences</subject><subject>Lung cancer</subject><subject>lung neoplasms</subject><subject>Oxidative stress</subject><subject>Pharmacology</subject><subject>protective effect</subject><subject>Stem Cells</subject><subject>Tumor necrosis factor-α</subject><issn>1071-2690</issn><issn>1543-706X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU1vFSEUhonR2Fr9Ay4MiRsXncrHwAzumsavpIkuNHFHGAauNDNwBebm9r_0x3ruhzbpQtlwDud5XwIvQi8puaCEdG8LpZLJhrC2IaQXbbN9hE6paHnTEfnjMdSkow2TipygZ6XcEFiKyqfohPdCMaHkKbr7mlN1toaNw857qHDy2GyCXSaTQ8RmZUIsFU9LXGFronUZb4LBIf4MQ6gBTkP0k5lnU0OK5zhtw2j2fqVmV8o5NnEEZlzsDtjbr9O6phLKO5jBCAxrTkcOmk0C7TLePkdPvJmKe3Hcz9D3D--_XX1qrr98_Hx1ed1YLlRtKKH9KAdOBuZGTqzt1EgHu_scw7rWM-pZ27JeuaGnfOBUCG-l4nRgjBje8zP05uC7zunX4krVcyjWTZOJLi1Fg4JLwVvF_o8SLkjHZd8C-voBepOWHOEhQAkqdukooNiBsjmVkp3X6xxmk281JXoXsz7ErCFmvY9Zb0H06mi9DLMb_0r-5AoAPwAFRnHl8v3d_7D9Dey_tKM</recordid><startdate>20240401</startdate><enddate>20240401</enddate><creator>Dang, Zhiguo</creator><creator>Liu, Songbo</creator><creator>Wang, XiaoJuan</creator><creator>Ren, Fangfang</creator><creator>Hussain, Shaik Althaf</creator><creator>Jia, Dong</creator><general>Springer US</general><general>Society for In Vitro Biology</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>4T-</scope><scope>7QL</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0008-6081-5590</orcidid></search><sort><creationdate>20240401</creationdate><title>Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study</title><author>Dang, Zhiguo ; Liu, Songbo ; Wang, XiaoJuan ; Ren, Fangfang ; Hussain, Shaik Althaf ; Jia, Dong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-1018d6b30b2ed30cc79d1bc1626a274f21f244289eb813b3155fc6931b220a383</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animal Genetics and Genomics</topic><topic>Anticancer properties</topic><topic>Apoptosis</topic><topic>Benzo(a)pyrene</topic><topic>Biomedical and Life Sciences</topic><topic>Cancer therapies</topic><topic>Cell Biology</topic><topic>Cell Culture</topic><topic>Cell cycle</topic><topic>Cell viability</topic><topic>Developmental Biology</topic><topic>Flow cytometry</topic><topic>In vivo methods and tests</topic><topic>Inflammation</topic><topic>interleukin-6</topic><topic>Investigations</topic><topic>Life Sciences</topic><topic>Lung cancer</topic><topic>lung neoplasms</topic><topic>Oxidative stress</topic><topic>Pharmacology</topic><topic>protective effect</topic><topic>Stem Cells</topic><topic>Tumor necrosis factor-α</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dang, Zhiguo</creatorcontrib><creatorcontrib>Liu, Songbo</creatorcontrib><creatorcontrib>Wang, XiaoJuan</creatorcontrib><creatorcontrib>Ren, Fangfang</creatorcontrib><creatorcontrib>Hussain, Shaik Althaf</creatorcontrib><creatorcontrib>Jia, Dong</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Docstoc</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>In vitro cellular & developmental biology. Animal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dang, Zhiguo</au><au>Liu, Songbo</au><au>Wang, XiaoJuan</au><au>Ren, Fangfang</au><au>Hussain, Shaik Althaf</au><au>Jia, Dong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study</atitle><jtitle>In vitro cellular & developmental biology. Animal</jtitle><stitle>In Vitro Cell.Dev.Biol.-Animal</stitle><addtitle>In Vitro Cell Dev Biol Anim</addtitle><date>2024-04-01</date><risdate>2024</risdate><volume>60</volume><issue>4</issue><spage>374</spage><epage>381</epage><pages>374-381</pages><issn>1071-2690</issn><eissn>1543-706X</eissn><abstract>The purpose of this research was to investigate whether or not avicularin (AVL) possesses any anticancer properties when tested against lung cancer. In the beginning, the effect that it had on the cellular viability of A549 cells was investigated, and it was discovered that AVL has a considerable negative impact on cellular viability. Following that, an investigation using flow cytometry was carried out to investigate its function in the process of apoptosis and the cell cycle of A549 cells. It has been discovered that AVL significantly promotes apoptosis and stops the cell cycle at the G2/M phase. The colony-forming capacity of A549 cells was observed to be greatly suppressed as the AVL concentration increased compared to the group that received no treatment. In addition to this, the benzo(a)pyrene in vivo model was established in order to investigate the pharmacological value of AVL. The findings revealed that AVL greatly prevented the formation of pro-inflammatory cytokines, in addition to the reduction in oxidative stress, which was evidenced by a reduction in the concentration of TNF-α, IL-1β, IL-6, and MDA with an improvement in the concentration of SOD and GPx, respectively. Our results successfully demonstrated the pharmacological benefit of avicularin against lung cancer, and it has been suggested that it showed a multifactorial effect.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>38592596</pmid><doi>10.1007/s11626-024-00854-x</doi><tpages>8</tpages><orcidid>https://orcid.org/0009-0008-6081-5590</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1071-2690 |
| ispartof | In vitro cellular & developmental biology. Animal, 2024-04, Vol.60 (4), p.374-381 |
| issn | 1071-2690 1543-706X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153653492 |
| source | Springer Nature - Complete Springer Journals |
| subjects | Animal Genetics and Genomics Anticancer properties Apoptosis Benzo(a)pyrene Biomedical and Life Sciences Cancer therapies Cell Biology Cell Culture Cell cycle Cell viability Developmental Biology Flow cytometry In vivo methods and tests Inflammation interleukin-6 Investigations Life Sciences Lung cancer lung neoplasms Oxidative stress Pharmacology protective effect Stem Cells Tumor necrosis factor-α |
| title | Protective effect of avicularin against lung cancer via inhibiting inflammation, oxidative stress, and induction of apoptosis: an in vitro and in vivo study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T20%3A47%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20avicularin%20against%20lung%20cancer%20via%20inhibiting%20inflammation,%20oxidative%20stress,%20and%20induction%20of%20apoptosis:%20an%20in%20vitro%20and%20in%20vivo%20study&rft.jtitle=In%20vitro%20cellular%20&%20developmental%20biology.%20Animal&rft.au=Dang,%20Zhiguo&rft.date=2024-04-01&rft.volume=60&rft.issue=4&rft.spage=374&rft.epage=381&rft.pages=374-381&rft.issn=1071-2690&rft.eissn=1543-706X&rft_id=info:doi/10.1007/s11626-024-00854-x&rft_dat=%3Cproquest_cross%3E3051510719%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3051510719&rft_id=info:pmid/38592596&rfr_iscdi=true |