The Human Ganglioside Interactome in Live Cells Revealed Using Clickable Photoaffinity Ganglioside Probes

Gangliosides, sialic acid bearing glycosphingolipids, are components of the outer leaflet of plasma membranes of all vertebrate cells. They contribute to cell regulation by interacting with proteins in their own membranes (cis) or their extracellular milieu (trans). As amphipathic membrane constitue...

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Veröffentlicht in:	Journal of the American Chemical Society 2024-07, Vol.146 (26), p.17801-17816
Hauptverfasser:	Zhang, Gao-Lan, Porter, Mitchell J., Awol, Abduselam K., Orsburn, Benjamin C., Canner, Samuel W., Gray, Jeffrey J., O’Meally, Robert N., Cole, Robert N., Schnaar, Ronald L.
Format:	Artikel
Sprache:	eng
Schlagworte:	cadherins cell adhesion Cell Membrane - chemistry Cell Membrane - metabolism Click Chemistry gangliosides Gangliosides - chemistry Gangliosides - metabolism gene ontology Humans integrins laminin mass spectrometry Molecular Probes - chemical synthesis Molecular Probes - chemistry Photoaffinity Labels - chemical synthesis Photoaffinity Labels - chemistry protein-protein interactions proteomics sialic acid surfactants
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