In Situ Visualizing Carboxylesterase Activity in Type 2 Diabetes Mellitus Using an Activatable Endoplasmic Reticulum Targetable Proximity Labeling Far-Red Fluorescent Probe

Carboxylesterase (CE), an enzyme widely present in organisms, is involved in various physiological and pathological processes. Changes in the levels of CEs in the liver may predict the presence of type 2 diabetes mellitus (T2DM). Here, a novel dicyanoisophorone (DCI)-based proximity-labeled far-red...

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Veröffentlicht in:	Analytical chemistry (Washington) 2024-07, Vol.96 (26), p.10724-10731
Hauptverfasser:	Xu, Ningge, Tang, Dandan, Liu, Heng, Liu, Mengyue, Wen, Zheng, Jiang, Tongmeng, Yu, Fabiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acarbose analytical chemistry Animals calcium Calcium homeostasis Carboxylesterase Carboxylesterase - antagonists & inhibitors Carboxylesterase - metabolism Cell lines chemical bonding Cytotoxicity Diabetes Diabetes mellitus Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - metabolism Effectiveness Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum Stress - drug effects fluorescence fluorescent dyes Fluorescent Dyes - chemical synthesis Fluorescent Dyes - chemistry Fluorescent indicators glycemic effect Hep G2 Cells Homeostasis Humans Liver Liver diseases Metabolic disorders Metformin Mice noninsulin-dependent diabetes mellitus Optical Imaging Real time Thapsigargin therapeutics Tunicamycin
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