On the mechanism of tissue-selective gene delivery by lipid nanoparticles

The era of nucleic acid nanomedicine has arrived, as evidenced by Patisiran, a small interfering RNA (siRNA) encapsulated lipid nanoparticle (LNP), and mRNA-loaded LNPs used in COVID-19 vaccines. The diversity of nano-designs for delivering nucleic acid molecules tested in Phase II/III clinical tria...

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Veröffentlicht in:	Journal of controlled release 2023-10, Vol.362, p.797-811
Hauptverfasser:	Kimura, Seigo, Harashima, Hideyoshi
Format:	Artikel
Sprache:	eng
Schlagworte:	Biodistribution Cellular response COVID-19 infection encapsulation Gene delivery Gene expression gene transfer Lipid nanoparticle lipids liver nanomedicine nanoparticles Plasmid DNA plasmids quantitative polymerase chain reaction RNA
Online-Zugang:	Volltext
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