Acute animal toxicity and genotoxicity of obliquumol, a potential new framework antifungal compound isolated from Ptaeroxylon obliquum (Rutaceae) leaf extracts

•Obliquumol had an LD50 >2000 mg/kg since there were no mortalities after 14 days.•At the highest dose of obliquumol, the mass, behaviour and food intake of the mice were not affected.•Gross necropsy and histopathological analysis on organs indicated hardly any effects of obliquumol.•P. obliquum...

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Veröffentlicht in:	South African journal of botany 2024-09, Vol.172, p.175-179
Hauptverfasser:	Ramadwa, T.E., McGaw, L.J., Madikizela, B., Eloff, J.N
Format:	Artikel
Sprache:	eng
Schlagworte:	acetone Acute toxicity Ames test animals antifungal agents antifungal properties chloroform class cytotoxicity food intake Genotoxicity hexane histopathology leaves lupeol necropsy Obliquumol Ptaeroxylon obliquum Rutaceae
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