Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer
Scope Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctiona...
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| Veröffentlicht in: | Molecular nutrition & food research 2024-06, Vol.68 (11), p.e2300793-n/a |
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| creator | Asoka, Ajay Sarija Kolikkandy, Anusha Nair, Bhagyalakshmi Kamath, Adithya J. Sethi, Gautam Nath, Lekshmi R. |
| description | Scope
Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctional polypeptide molecule that acts as a pro‐fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro‐carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF‐β can induce epithelial‐to‐mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF‐β pathway can be a promising therapeutic option against HCC.
Methods and Results
We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF‐β pathway against liver cancer.
Conclusion
Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation‐induced HCC and they also have the maximum number of ongoing in‐vivo and in‐vitro studies.
Modulation of TGF‐β path way with culinary Indian spices against HCC. |
| doi_str_mv | 10.1002/mnfr.202300793 |
| format | Article |
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Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctional polypeptide molecule that acts as a pro‐fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro‐carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF‐β can induce epithelial‐to‐mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF‐β pathway can be a promising therapeutic option against HCC.
Methods and Results
We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF‐β pathway against liver cancer.
Conclusion
Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation‐induced HCC and they also have the maximum number of ongoing in‐vivo and in‐vitro studies.
Modulation of TGF‐β path way with culinary Indian spices against HCC.</description><identifier>ISSN: 1613-4125</identifier><identifier>ISSN: 1613-4133</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.202300793</identifier><identifier>PMID: 38766929</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>bioactive compounds ; black pepper ; Carcinogens ; cinnamon ; Cirrhosis ; Curcumin ; cytokines ; Fatty liver ; fenugreek ; Fibrosis ; food research ; garlic ; ginger ; Growth factors ; Hepatitis B ; Hepatocellular carcinoma ; hepatoma ; immune evasion ; immunosuppression ; Indian spices ; Inflammation ; liver ; Liver cancer ; Liver cirrhosis ; Liver diseases ; nutrition ; Polypeptides ; Signal transduction ; Spices ; TGF‐β signaling pathway ; therapeutics ; Transforming growth factor-b ; turmeric</subject><ispartof>Molecular nutrition & food research, 2024-06, Vol.68 (11), p.e2300793-n/a</ispartof><rights>2024 Wiley‐VCH GmbH</rights><rights>2024 Wiley‐VCH GmbH.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3567-efe9825f73a201cdfc192ae434f088f5e75df6af0745596f64fda7e46be2f3a63</cites><orcidid>0000-0002-7726-7219 ; 0000-0002-8677-8475</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.202300793$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.202300793$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38766929$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Asoka, Ajay Sarija</creatorcontrib><creatorcontrib>Kolikkandy, Anusha</creatorcontrib><creatorcontrib>Nair, Bhagyalakshmi</creatorcontrib><creatorcontrib>Kamath, Adithya J.</creatorcontrib><creatorcontrib>Sethi, Gautam</creatorcontrib><creatorcontrib>Nath, Lekshmi R.</creatorcontrib><title>Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer</title><title>Molecular nutrition & food research</title><addtitle>Mol Nutr Food Res</addtitle><description>Scope
Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctional polypeptide molecule that acts as a pro‐fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro‐carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF‐β can induce epithelial‐to‐mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF‐β pathway can be a promising therapeutic option against HCC.
Methods and Results
We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF‐β pathway against liver cancer.
Conclusion
Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation‐induced HCC and they also have the maximum number of ongoing in‐vivo and in‐vitro studies.
Modulation of TGF‐β path way with culinary Indian spices against HCC.</description><subject>bioactive compounds</subject><subject>black pepper</subject><subject>Carcinogens</subject><subject>cinnamon</subject><subject>Cirrhosis</subject><subject>Curcumin</subject><subject>cytokines</subject><subject>Fatty liver</subject><subject>fenugreek</subject><subject>Fibrosis</subject><subject>food research</subject><subject>garlic</subject><subject>ginger</subject><subject>Growth factors</subject><subject>Hepatitis B</subject><subject>Hepatocellular carcinoma</subject><subject>hepatoma</subject><subject>immune evasion</subject><subject>immunosuppression</subject><subject>Indian spices</subject><subject>Inflammation</subject><subject>liver</subject><subject>Liver cancer</subject><subject>Liver cirrhosis</subject><subject>Liver diseases</subject><subject>nutrition</subject><subject>Polypeptides</subject><subject>Signal transduction</subject><subject>Spices</subject><subject>TGF‐β signaling pathway</subject><subject>therapeutics</subject><subject>Transforming growth factor-b</subject><subject>turmeric</subject><issn>1613-4125</issn><issn>1613-4133</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqF0c9uEzEQBnALgWgpXDkiS1y4JNge_9k9oqgpkVKo0nJeubvj1NWuN9hZqtx4BJ6FB-EheBK8Tcmhl55mDr_5DvMR8pazKWdMfOyCi1PBBDBmSnhGjrnmMJEc4PlhF-qIvErpljHgQsJLcgSF0boU5TEZVn2LtHd0NrQ-2Liji9B4G-jlxteYqA90e4N0heuhtVvfh9Fenc3__vz15ze99Otg892aXtjtzZ3djX4RXGu77l5nlvOGGhu69D8w0pkNNcbX5IWzbcI3D_OEfJufXs0-T5ZfzxazT8tJDUqbCTosC6GcASsYrxtX81JYlCAdKwqn0KjGaeuYkUqV2mnpGmtQ6msUDqyGE_Jhn7uJ_fcB07bqfKqxbW3AfkgVcAUaeMn505Qpw4zihcz0_SN62w8xP2JUhulSKs6ymu5VHfuUIrpqE32XP1xxVo3dVWN31aG7fPDuIXa47rA58P9lZSD34M63uHsirjr_Ml9Jow38A1W2ptA</recordid><startdate>202406</startdate><enddate>202406</enddate><creator>Asoka, Ajay Sarija</creator><creator>Kolikkandy, Anusha</creator><creator>Nair, Bhagyalakshmi</creator><creator>Kamath, Adithya J.</creator><creator>Sethi, Gautam</creator><creator>Nath, Lekshmi R.</creator><general>Wiley Subscription Services, Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7T5</scope><scope>7T7</scope><scope>7TK</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-7726-7219</orcidid><orcidid>https://orcid.org/0000-0002-8677-8475</orcidid></search><sort><creationdate>202406</creationdate><title>Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer</title><author>Asoka, Ajay Sarija ; Kolikkandy, Anusha ; Nair, Bhagyalakshmi ; Kamath, Adithya J. ; Sethi, Gautam ; Nath, Lekshmi R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3567-efe9825f73a201cdfc192ae434f088f5e75df6af0745596f64fda7e46be2f3a63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>bioactive compounds</topic><topic>black pepper</topic><topic>Carcinogens</topic><topic>cinnamon</topic><topic>Cirrhosis</topic><topic>Curcumin</topic><topic>cytokines</topic><topic>Fatty liver</topic><topic>fenugreek</topic><topic>Fibrosis</topic><topic>food research</topic><topic>garlic</topic><topic>ginger</topic><topic>Growth factors</topic><topic>Hepatitis B</topic><topic>Hepatocellular carcinoma</topic><topic>hepatoma</topic><topic>immune evasion</topic><topic>immunosuppression</topic><topic>Indian spices</topic><topic>Inflammation</topic><topic>liver</topic><topic>Liver cancer</topic><topic>Liver cirrhosis</topic><topic>Liver diseases</topic><topic>nutrition</topic><topic>Polypeptides</topic><topic>Signal transduction</topic><topic>Spices</topic><topic>TGF‐β signaling pathway</topic><topic>therapeutics</topic><topic>Transforming growth factor-b</topic><topic>turmeric</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Asoka, Ajay Sarija</creatorcontrib><creatorcontrib>Kolikkandy, Anusha</creatorcontrib><creatorcontrib>Nair, Bhagyalakshmi</creatorcontrib><creatorcontrib>Kamath, Adithya J.</creatorcontrib><creatorcontrib>Sethi, Gautam</creatorcontrib><creatorcontrib>Nath, Lekshmi R.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Asoka, Ajay Sarija</au><au>Kolikkandy, Anusha</au><au>Nair, Bhagyalakshmi</au><au>Kamath, Adithya J.</au><au>Sethi, Gautam</au><au>Nath, Lekshmi R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol Nutr Food Res</addtitle><date>2024-06</date><risdate>2024</risdate><volume>68</volume><issue>11</issue><spage>e2300793</spage><epage>n/a</epage><pages>e2300793-n/a</pages><issn>1613-4125</issn><issn>1613-4133</issn><eissn>1613-4133</eissn><abstract>Scope
Hepatocellular carcinoma (HCC) results from various etiologies, such as Hepatitis B and C, Alcoholic and Non‐alcoholic fatty liver disorders, fibrosis, and cirrhosis. About 80 to 90% of HCC cases possess cirrhosis, which is brought on by persistent liver inflammation. TGF‐β is a multifunctional polypeptide molecule that acts as a pro‐fibrogenic marker, inflammatory cytokine, immunosuppressive agent, and pro‐carcinogenic growth factor during the progression of HCC. The preclinical and clinical evidence illustrates that TGF‐β can induce epithelial‐to‐mesenchymal transition, promoting progression and hepatocyte immune evasion. Therefore, targeting the TGF‐β pathway can be a promising therapeutic option against HCC.
Methods and Results
We carry out a systemic analysis of eight potentially selected culinary Indian spices: Turmeric, Black pepper, Ginger, Garlic, Fenugreek, Red pepper, Clove, Cinnamon, and their bioactives in regulation of the TGF‐β pathway against liver cancer.
Conclusion
Turmeric and its active constituent, curcumin, possess the highest therapeutic potential in treating inflammation‐induced HCC and they also have the maximum number of ongoing in‐vivo and in‐vitro studies.
Modulation of TGF‐β path way with culinary Indian spices against HCC.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>38766929</pmid><doi>10.1002/mnfr.202300793</doi><tpages>17</tpages><orcidid>https://orcid.org/0000-0002-7726-7219</orcidid><orcidid>https://orcid.org/0000-0002-8677-8475</orcidid></addata></record> |
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| identifier | ISSN: 1613-4125 |
| ispartof | Molecular nutrition & food research, 2024-06, Vol.68 (11), p.e2300793-n/a |
| issn | 1613-4125 1613-4133 1613-4133 |
| language | eng |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | bioactive compounds black pepper Carcinogens cinnamon Cirrhosis Curcumin cytokines Fatty liver fenugreek Fibrosis food research garlic ginger Growth factors Hepatitis B Hepatocellular carcinoma hepatoma immune evasion immunosuppression Indian spices Inflammation liver Liver cancer Liver cirrhosis Liver diseases nutrition Polypeptides Signal transduction Spices TGF‐β signaling pathway therapeutics Transforming growth factor-b turmeric |
| title | Role of Culinary Indian Spices in the Regulation of TGF‐β Signaling Pathway in Inflammation‐Induced Liver Cancer |
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