Exploring the antibiofilm efficacy of cinnamaldehyde against Malassezia globosa associated pityriasis versicolor
Malassezia globosa is a commensal basidiomycetous yeast occurring on the skin that causes pityriasis versicolor (PV) and seborrheic dermatitis, but that has also been implicated in other dermatoses. Cinnamaldehyde (CM) has antibacterial, antioxidant, and anti-inflammatory activities, but the effect...
Gespeichert in:
| Veröffentlicht in: | Phytomedicine (Stuttgart) 2024-07, Vol.130, p.155542, Article 155542 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | 155542 |
| container_title | Phytomedicine (Stuttgart) |
| container_volume | 130 |
| creator | Liu, Miao-Miao Zhao, Yu-Jing Boekhout, Teun Wang, Qi-Ming |
| description | Malassezia globosa is a commensal basidiomycetous yeast occurring on the skin that causes pityriasis versicolor (PV) and seborrheic dermatitis, but that has also been implicated in other dermatoses. Cinnamaldehyde (CM) has antibacterial, antioxidant, and anti-inflammatory activities, but the effect of CM on M. globosa-infected PV has not been clarified.
The study aimed to investigate the possible antifungal and antibiofilm activities of CM against M. globosa-infected PV in vivo and in vitro.
The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of CM against M. globosa. The crystal violet staining assay and XTT assay were used to investigate the inhibition of CM on biofilm formation and the eradication of mature biofilms. The visualizations of the biofilm and cell distribution in the biofilm matrix were performed with a scanning electron microscope and confocal laser scanning microscope. The kits of antioxidant kinase were used to determine the activities of oxidative stress markers in M. globosa-stimulated HaCaT cells. Western blot assays were used to evaluate the role of TLR2/NF-κB in vitro. Furthermore, the protective effect of CM was assessed in M. globosa-associated PV mice. The expressions of inflammatory cytokines and apoptosis were screened using ELISA assays. The expressions of interleukin-6 and tumor necrosis factor-α were measured by an immunohistochemistry method in vivo.
Our results showed that the MIC of CM against planktonic cells of M. globosa was 4 µg/ml and treatment with 20 × MIC CM eradicated mature biofilms of M. globosa. In vitro, after CM treatment the levels of oxidative stress indicators (i.e., superoxide dismutase, catalase, glutathione) significantly increased, while the levels of malondialdehyde decreased. In addition, the expression of TLR2/NF-κB in HaCaT cells was significantly reduced after CM treatment. On the other hand, an in vivo therapeutic effect of CM was assessed against M. globosa-infected mice. The fungal load on the skin decreased after treatment with CM compared to the M. globosa-infected group. In addition, the uninfected animals showed a normal skin structure, whereas, the M. globosa-infected mice showed extensive infiltration of neutrophils in skin tissues that improved after treatment with CM. Meanwhile, the levels of inflammatory and apoptotic factors improved after CM treatment.
Our results showed that CM inhibits the biofilm formation of M. globosa and eradicates ma |
| doi_str_mv | 10.1016/j.phymed.2024.155542 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153630559</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0944711324002071</els_id><sourcerecordid>3153630559</sourcerecordid><originalsourceid>FETCH-LOGICAL-c344t-8f461ce5482e22fe55270b693a4fe83977623e63ee54f28c645121ad59f069803</originalsourceid><addsrcrecordid>eNqFkU1r3DAQhkVISLZp_0EpOubirb5tXwIlJGkhJZcGchNaebQ7i205kjfU_fX14uTanoZhnpkX5iHkM2drzrj5ul8Pu6mDZi2YUGuutVbihKy44VXBav18SlasVqooOZcX5EPOe8a4qkt2Ti5kVQkplVyR4fb30MaE_ZaOO6CuH3GDMWDbUQgBvfMTjYF67HvXubaB3dTM2NZhn0f607UuZ_iDjm7buInZ0bmPHt0IDR1wnBK6jJm-Qsro45z0kZwF12b49FYvydPd7a-b78XD4_2Pm28PhZdKjUUVlOEetKoECBFAa1GyjamlUwEqWZelERKMhBkJovJGaS64a3QdmKkrJi_J1XJ3SPHlAHm0HWYPbet6iIdsJdfSSKZ1_X-UGamMYFrMqFpQn2LOCYIdEnYuTZYze9Ri93bRYo9a7KJlXvvylnDYHGfvS-8eZuB6AWB-yStCstkj9B4aTOBH20T8d8JfMXChQw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3063462052</pqid></control><display><type>article</type><title>Exploring the antibiofilm efficacy of cinnamaldehyde against Malassezia globosa associated pityriasis versicolor</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Liu, Miao-Miao ; Zhao, Yu-Jing ; Boekhout, Teun ; Wang, Qi-Ming</creator><creatorcontrib>Liu, Miao-Miao ; Zhao, Yu-Jing ; Boekhout, Teun ; Wang, Qi-Ming</creatorcontrib><description>Malassezia globosa is a commensal basidiomycetous yeast occurring on the skin that causes pityriasis versicolor (PV) and seborrheic dermatitis, but that has also been implicated in other dermatoses. Cinnamaldehyde (CM) has antibacterial, antioxidant, and anti-inflammatory activities, but the effect of CM on M. globosa-infected PV has not been clarified.
The study aimed to investigate the possible antifungal and antibiofilm activities of CM against M. globosa-infected PV in vivo and in vitro.
The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of CM against M. globosa. The crystal violet staining assay and XTT assay were used to investigate the inhibition of CM on biofilm formation and the eradication of mature biofilms. The visualizations of the biofilm and cell distribution in the biofilm matrix were performed with a scanning electron microscope and confocal laser scanning microscope. The kits of antioxidant kinase were used to determine the activities of oxidative stress markers in M. globosa-stimulated HaCaT cells. Western blot assays were used to evaluate the role of TLR2/NF-κB in vitro. Furthermore, the protective effect of CM was assessed in M. globosa-associated PV mice. The expressions of inflammatory cytokines and apoptosis were screened using ELISA assays. The expressions of interleukin-6 and tumor necrosis factor-α were measured by an immunohistochemistry method in vivo.
Our results showed that the MIC of CM against planktonic cells of M. globosa was 4 µg/ml and treatment with 20 × MIC CM eradicated mature biofilms of M. globosa. In vitro, after CM treatment the levels of oxidative stress indicators (i.e., superoxide dismutase, catalase, glutathione) significantly increased, while the levels of malondialdehyde decreased. In addition, the expression of TLR2/NF-κB in HaCaT cells was significantly reduced after CM treatment. On the other hand, an in vivo therapeutic effect of CM was assessed against M. globosa-infected mice. The fungal load on the skin decreased after treatment with CM compared to the M. globosa-infected group. In addition, the uninfected animals showed a normal skin structure, whereas, the M. globosa-infected mice showed extensive infiltration of neutrophils in skin tissues that improved after treatment with CM. Meanwhile, the levels of inflammatory and apoptotic factors improved after CM treatment.
Our results showed that CM inhibits the biofilm formation of M. globosa and eradicates mature biofilms of M. globosa. Treatment with CM significantly decreased oxidative stress, apoptosis, and inflammatory markers in the skin tissue and HaCaT cells. Hence, this study suggests that CM is a good candidate therapeutic agent against M. globosa-induced PV infections because of its antifungal, antibiofilm, and anti-inflammatory properties.
[Display omitted]</description><identifier>ISSN: 0944-7113</identifier><identifier>ISSN: 1618-095X</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2024.155542</identifier><identifier>PMID: 38823343</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>Acrolein - analogs & derivatives ; Acrolein - pharmacology ; Animals ; Antifungal Agents - pharmacology ; antioxidants ; Antioxidants - pharmacology ; apoptosis ; Biofilm ; Biofilms - drug effects ; catalase ; Cinnamaldehyde ; dermatitis ; gentian violet ; glutathione ; HaCaT Cells ; Humans ; immunohistochemistry ; Inflammation ; interleukin-6 ; Interleukin-6 - metabolism ; Malassezia ; Malassezia - drug effects ; Malassezia globosa ; malondialdehyde ; Mice ; Microbial Sensitivity Tests ; minimum inhibitory concentration ; necrosis ; neoplasms ; neutrophils ; NF-kappa B - metabolism ; oxidative stress ; Oxidative Stress - drug effects ; Pityriasis versicolor ; plankton ; protective effect ; Skin ; Skin - drug effects ; Skin - microbiology ; superoxide dismutase ; therapeutics ; Tinea Versicolor - drug therapy ; Toll-Like Receptor 2 - metabolism ; Tumor Necrosis Factor-alpha - metabolism ; Western blotting ; yeasts</subject><ispartof>Phytomedicine (Stuttgart), 2024-07, Vol.130, p.155542, Article 155542</ispartof><rights>2024 Elsevier GmbH</rights><rights>Copyright © 2024 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-8f461ce5482e22fe55270b693a4fe83977623e63ee54f28c645121ad59f069803</cites><orcidid>0000-0002-0476-3609</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711324002071$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38823343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Miao-Miao</creatorcontrib><creatorcontrib>Zhao, Yu-Jing</creatorcontrib><creatorcontrib>Boekhout, Teun</creatorcontrib><creatorcontrib>Wang, Qi-Ming</creatorcontrib><title>Exploring the antibiofilm efficacy of cinnamaldehyde against Malassezia globosa associated pityriasis versicolor</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>Malassezia globosa is a commensal basidiomycetous yeast occurring on the skin that causes pityriasis versicolor (PV) and seborrheic dermatitis, but that has also been implicated in other dermatoses. Cinnamaldehyde (CM) has antibacterial, antioxidant, and anti-inflammatory activities, but the effect of CM on M. globosa-infected PV has not been clarified.
The study aimed to investigate the possible antifungal and antibiofilm activities of CM against M. globosa-infected PV in vivo and in vitro.
The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of CM against M. globosa. The crystal violet staining assay and XTT assay were used to investigate the inhibition of CM on biofilm formation and the eradication of mature biofilms. The visualizations of the biofilm and cell distribution in the biofilm matrix were performed with a scanning electron microscope and confocal laser scanning microscope. The kits of antioxidant kinase were used to determine the activities of oxidative stress markers in M. globosa-stimulated HaCaT cells. Western blot assays were used to evaluate the role of TLR2/NF-κB in vitro. Furthermore, the protective effect of CM was assessed in M. globosa-associated PV mice. The expressions of inflammatory cytokines and apoptosis were screened using ELISA assays. The expressions of interleukin-6 and tumor necrosis factor-α were measured by an immunohistochemistry method in vivo.
Our results showed that the MIC of CM against planktonic cells of M. globosa was 4 µg/ml and treatment with 20 × MIC CM eradicated mature biofilms of M. globosa. In vitro, after CM treatment the levels of oxidative stress indicators (i.e., superoxide dismutase, catalase, glutathione) significantly increased, while the levels of malondialdehyde decreased. In addition, the expression of TLR2/NF-κB in HaCaT cells was significantly reduced after CM treatment. On the other hand, an in vivo therapeutic effect of CM was assessed against M. globosa-infected mice. The fungal load on the skin decreased after treatment with CM compared to the M. globosa-infected group. In addition, the uninfected animals showed a normal skin structure, whereas, the M. globosa-infected mice showed extensive infiltration of neutrophils in skin tissues that improved after treatment with CM. Meanwhile, the levels of inflammatory and apoptotic factors improved after CM treatment.
Our results showed that CM inhibits the biofilm formation of M. globosa and eradicates mature biofilms of M. globosa. Treatment with CM significantly decreased oxidative stress, apoptosis, and inflammatory markers in the skin tissue and HaCaT cells. Hence, this study suggests that CM is a good candidate therapeutic agent against M. globosa-induced PV infections because of its antifungal, antibiofilm, and anti-inflammatory properties.
[Display omitted]</description><subject>Acrolein - analogs & derivatives</subject><subject>Acrolein - pharmacology</subject><subject>Animals</subject><subject>Antifungal Agents - pharmacology</subject><subject>antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>apoptosis</subject><subject>Biofilm</subject><subject>Biofilms - drug effects</subject><subject>catalase</subject><subject>Cinnamaldehyde</subject><subject>dermatitis</subject><subject>gentian violet</subject><subject>glutathione</subject><subject>HaCaT Cells</subject><subject>Humans</subject><subject>immunohistochemistry</subject><subject>Inflammation</subject><subject>interleukin-6</subject><subject>Interleukin-6 - metabolism</subject><subject>Malassezia</subject><subject>Malassezia - drug effects</subject><subject>Malassezia globosa</subject><subject>malondialdehyde</subject><subject>Mice</subject><subject>Microbial Sensitivity Tests</subject><subject>minimum inhibitory concentration</subject><subject>necrosis</subject><subject>neoplasms</subject><subject>neutrophils</subject><subject>NF-kappa B - metabolism</subject><subject>oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Pityriasis versicolor</subject><subject>plankton</subject><subject>protective effect</subject><subject>Skin</subject><subject>Skin - drug effects</subject><subject>Skin - microbiology</subject><subject>superoxide dismutase</subject><subject>therapeutics</subject><subject>Tinea Versicolor - drug therapy</subject><subject>Toll-Like Receptor 2 - metabolism</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Western blotting</subject><subject>yeasts</subject><issn>0944-7113</issn><issn>1618-095X</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1r3DAQhkVISLZp_0EpOubirb5tXwIlJGkhJZcGchNaebQ7i205kjfU_fX14uTanoZhnpkX5iHkM2drzrj5ul8Pu6mDZi2YUGuutVbihKy44VXBav18SlasVqooOZcX5EPOe8a4qkt2Ti5kVQkplVyR4fb30MaE_ZaOO6CuH3GDMWDbUQgBvfMTjYF67HvXubaB3dTM2NZhn0f607UuZ_iDjm7buInZ0bmPHt0IDR1wnBK6jJm-Qsro45z0kZwF12b49FYvydPd7a-b78XD4_2Pm28PhZdKjUUVlOEetKoECBFAa1GyjamlUwEqWZelERKMhBkJovJGaS64a3QdmKkrJi_J1XJ3SPHlAHm0HWYPbet6iIdsJdfSSKZ1_X-UGamMYFrMqFpQn2LOCYIdEnYuTZYze9Ri93bRYo9a7KJlXvvylnDYHGfvS-8eZuB6AWB-yStCstkj9B4aTOBH20T8d8JfMXChQw</recordid><startdate>20240725</startdate><enddate>20240725</enddate><creator>Liu, Miao-Miao</creator><creator>Zhao, Yu-Jing</creator><creator>Boekhout, Teun</creator><creator>Wang, Qi-Ming</creator><general>Elsevier GmbH</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-0476-3609</orcidid></search><sort><creationdate>20240725</creationdate><title>Exploring the antibiofilm efficacy of cinnamaldehyde against Malassezia globosa associated pityriasis versicolor</title><author>Liu, Miao-Miao ; Zhao, Yu-Jing ; Boekhout, Teun ; Wang, Qi-Ming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-8f461ce5482e22fe55270b693a4fe83977623e63ee54f28c645121ad59f069803</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acrolein - analogs & derivatives</topic><topic>Acrolein - pharmacology</topic><topic>Animals</topic><topic>Antifungal Agents - pharmacology</topic><topic>antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>apoptosis</topic><topic>Biofilm</topic><topic>Biofilms - drug effects</topic><topic>catalase</topic><topic>Cinnamaldehyde</topic><topic>dermatitis</topic><topic>gentian violet</topic><topic>glutathione</topic><topic>HaCaT Cells</topic><topic>Humans</topic><topic>immunohistochemistry</topic><topic>Inflammation</topic><topic>interleukin-6</topic><topic>Interleukin-6 - metabolism</topic><topic>Malassezia</topic><topic>Malassezia - drug effects</topic><topic>Malassezia globosa</topic><topic>malondialdehyde</topic><topic>Mice</topic><topic>Microbial Sensitivity Tests</topic><topic>minimum inhibitory concentration</topic><topic>necrosis</topic><topic>neoplasms</topic><topic>neutrophils</topic><topic>NF-kappa B - metabolism</topic><topic>oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Pityriasis versicolor</topic><topic>plankton</topic><topic>protective effect</topic><topic>Skin</topic><topic>Skin - drug effects</topic><topic>Skin - microbiology</topic><topic>superoxide dismutase</topic><topic>therapeutics</topic><topic>Tinea Versicolor - drug therapy</topic><topic>Toll-Like Receptor 2 - metabolism</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Western blotting</topic><topic>yeasts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Miao-Miao</creatorcontrib><creatorcontrib>Zhao, Yu-Jing</creatorcontrib><creatorcontrib>Boekhout, Teun</creatorcontrib><creatorcontrib>Wang, Qi-Ming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Miao-Miao</au><au>Zhao, Yu-Jing</au><au>Boekhout, Teun</au><au>Wang, Qi-Ming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Exploring the antibiofilm efficacy of cinnamaldehyde against Malassezia globosa associated pityriasis versicolor</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2024-07-25</date><risdate>2024</risdate><volume>130</volume><spage>155542</spage><pages>155542-</pages><artnum>155542</artnum><issn>0944-7113</issn><issn>1618-095X</issn><eissn>1618-095X</eissn><abstract>Malassezia globosa is a commensal basidiomycetous yeast occurring on the skin that causes pityriasis versicolor (PV) and seborrheic dermatitis, but that has also been implicated in other dermatoses. Cinnamaldehyde (CM) has antibacterial, antioxidant, and anti-inflammatory activities, but the effect of CM on M. globosa-infected PV has not been clarified.
The study aimed to investigate the possible antifungal and antibiofilm activities of CM against M. globosa-infected PV in vivo and in vitro.
The broth microdilution method was used to determine the minimum inhibitory concentration (MIC) of CM against M. globosa. The crystal violet staining assay and XTT assay were used to investigate the inhibition of CM on biofilm formation and the eradication of mature biofilms. The visualizations of the biofilm and cell distribution in the biofilm matrix were performed with a scanning electron microscope and confocal laser scanning microscope. The kits of antioxidant kinase were used to determine the activities of oxidative stress markers in M. globosa-stimulated HaCaT cells. Western blot assays were used to evaluate the role of TLR2/NF-κB in vitro. Furthermore, the protective effect of CM was assessed in M. globosa-associated PV mice. The expressions of inflammatory cytokines and apoptosis were screened using ELISA assays. The expressions of interleukin-6 and tumor necrosis factor-α were measured by an immunohistochemistry method in vivo.
Our results showed that the MIC of CM against planktonic cells of M. globosa was 4 µg/ml and treatment with 20 × MIC CM eradicated mature biofilms of M. globosa. In vitro, after CM treatment the levels of oxidative stress indicators (i.e., superoxide dismutase, catalase, glutathione) significantly increased, while the levels of malondialdehyde decreased. In addition, the expression of TLR2/NF-κB in HaCaT cells was significantly reduced after CM treatment. On the other hand, an in vivo therapeutic effect of CM was assessed against M. globosa-infected mice. The fungal load on the skin decreased after treatment with CM compared to the M. globosa-infected group. In addition, the uninfected animals showed a normal skin structure, whereas, the M. globosa-infected mice showed extensive infiltration of neutrophils in skin tissues that improved after treatment with CM. Meanwhile, the levels of inflammatory and apoptotic factors improved after CM treatment.
Our results showed that CM inhibits the biofilm formation of M. globosa and eradicates mature biofilms of M. globosa. Treatment with CM significantly decreased oxidative stress, apoptosis, and inflammatory markers in the skin tissue and HaCaT cells. Hence, this study suggests that CM is a good candidate therapeutic agent against M. globosa-induced PV infections because of its antifungal, antibiofilm, and anti-inflammatory properties.
[Display omitted]</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>38823343</pmid><doi>10.1016/j.phymed.2024.155542</doi><orcidid>https://orcid.org/0000-0002-0476-3609</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0944-7113 |
| ispartof | Phytomedicine (Stuttgart), 2024-07, Vol.130, p.155542, Article 155542 |
| issn | 0944-7113 1618-095X 1618-095X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153630559 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Acrolein - analogs & derivatives Acrolein - pharmacology Animals Antifungal Agents - pharmacology antioxidants Antioxidants - pharmacology apoptosis Biofilm Biofilms - drug effects catalase Cinnamaldehyde dermatitis gentian violet glutathione HaCaT Cells Humans immunohistochemistry Inflammation interleukin-6 Interleukin-6 - metabolism Malassezia Malassezia - drug effects Malassezia globosa malondialdehyde Mice Microbial Sensitivity Tests minimum inhibitory concentration necrosis neoplasms neutrophils NF-kappa B - metabolism oxidative stress Oxidative Stress - drug effects Pityriasis versicolor plankton protective effect Skin Skin - drug effects Skin - microbiology superoxide dismutase therapeutics Tinea Versicolor - drug therapy Toll-Like Receptor 2 - metabolism Tumor Necrosis Factor-alpha - metabolism Western blotting yeasts |
| title | Exploring the antibiofilm efficacy of cinnamaldehyde against Malassezia globosa associated pityriasis versicolor |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-09T00%3A23%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Exploring%20the%20antibiofilm%20efficacy%20of%20cinnamaldehyde%20against%20Malassezia%20globosa%20associated%20pityriasis%20versicolor&rft.jtitle=Phytomedicine%20(Stuttgart)&rft.au=Liu,%20Miao-Miao&rft.date=2024-07-25&rft.volume=130&rft.spage=155542&rft.pages=155542-&rft.artnum=155542&rft.issn=0944-7113&rft.eissn=1618-095X&rft_id=info:doi/10.1016/j.phymed.2024.155542&rft_dat=%3Cproquest_cross%3E3153630559%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3063462052&rft_id=info:pmid/38823343&rft_els_id=S0944711324002071&rfr_iscdi=true |