Metabolomics profiling and chemoresistance mechanisms in ovarian cancer cell lines: Implications for targeting glutathione pathway

Ovarian cancer presents a significant challenge due to its high rate of chemoresistance, which complicates the effectiveness of drug-response therapy. This study provides a comprehensive metabolomic analysis of ovarian cancer cell lines OVCAR-3 and SK-OV-3, characterizing their distinct metabolic la...

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Veröffentlicht in:	Life sciences (1973) 2023-11, Vol.333, p.122166-122166, Article 122166
Hauptverfasser:	Alarcon-Zapata, Pedro, Perez, Andy J., Toledo-Oñate, Karin, Contreras, Hector, Ormazabal, Valeska, Nova-Lamperti, Estefania, Aguayo, Claudio A., Salomon, Carlos, Zuniga, Felipe A.
Format:	Artikel
Sprache:	eng
Schlagworte:	beta oxidation biosynthesis cell proliferation chemometrics Chemoresistance cytotoxicity doxorubicin drug resistance drug therapy energy Glutathione Metabolomics neoplasm cells Ovarian cancer ovarian neoplasms SK-OV-3 cells
Online-Zugang:	Volltext
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