Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture
Mini-abstract We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a...
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| Veröffentlicht in: | Archives of osteoporosis 2024-03, Vol.19 (1), p.20-20, Article 20 |
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| creator | Marchasson, Gauthier Philippoteaux, Cécile Legroux-Gérot, Isabelle Hélène, Béhal Cortet, Bernard Paccou, Julien |
| description | Mini-abstract
We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a mean difference of 1 SD.
Purpose
This study aimed to compare the mean T-scores of obese and non-obese patients after recent fragility fractures.
Methods
Over a period of 5 and a half years, from January 2016 to May 2021, patients from a fracture liaison service were identified and their demographic characteristics, osteoporosis risk factors, BMD T-scores, and fracture sites were compared between obese (BMI ≥ 30 kg/m
2
) and non-obese (19 kg/m
2
|
| doi_str_mv | 10.1007/s11657-024-01379-2 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153624893</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3153624893</sourcerecordid><originalsourceid>FETCH-LOGICAL-c331t-3a8260c1337f9593ffe4599679d065ba3f3973796f5f81757d73ebf6d29e316d3</originalsourceid><addsrcrecordid>eNqFkc9uFSEYxSdGY2v1BVwYlm6o_BlgWGrTWpObuLCuCQMfNzQzcIWZNn0Y31XauRpXuuIQfueQnNN1byk5p4SoD5VSKRQmrMeEcqUxe9ad0kEyzAXtn_-lT7pXtd4SIgkV8mV3wgfBiNDstPv5KSdAc0xQ7IQ8pBqXB3SDq8sFKnJ5PtgSa05ohOUeIKE8QgVkk0cpJ7zdYvLxLvrVTrVpN60efBPIoqti3bIWQLton2K-QbmLDlDI05TvY9o3qICDtKBQ7D5Oj_-Ho-t19yK0THhzPM-671eXNxfXePf185eLjzvsOKcL5nZgkjjKuQpaaB4C9EJrqbQnUoyWB65VK0gGEQaqhPKKwxikZxo4lZ6fde-33EPJP1aoi5ljdTBNNkFeq-FUcMn6QfP_okyrvhXNhWwo21BXcq0FgjmUONvyYCgxjwuabUHTFjRPCxrWTO-O-es4g_9j-T1ZA_gG1PaU9lDMbV5LavX8K_YXavaojA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2974006356</pqid></control><display><type>article</type><title>Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture</title><source>MEDLINE</source><source>SpringerLink</source><creator>Marchasson, Gauthier ; Philippoteaux, Cécile ; Legroux-Gérot, Isabelle ; Hélène, Béhal ; Cortet, Bernard ; Paccou, Julien</creator><creatorcontrib>Marchasson, Gauthier ; Philippoteaux, Cécile ; Legroux-Gérot, Isabelle ; Hélène, Béhal ; Cortet, Bernard ; Paccou, Julien</creatorcontrib><description>Mini-abstract
We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a mean difference of 1 SD.
Purpose
This study aimed to compare the mean T-scores of obese and non-obese patients after recent fragility fractures.
Methods
Over a period of 5 and a half years, from January 2016 to May 2021, patients from a fracture liaison service were identified and their demographic characteristics, osteoporosis risk factors, BMD T-scores, and fracture sites were compared between obese (BMI ≥ 30 kg/m
2
) and non-obese (19 kg/m
2
< BMI < 30 kg/m
2
) patients.
Results
A total of 712 patients were included (80.1% women; mean age 73.8 ± 11.3 years). Sixteen % had type 2 diabetes mellitus and 80% had a major osteoporotic fracture (MOF). 135 patients were obese and 577 non-obese, with obese patients younger (
p
< 0.001) and more frequently female (
p
= 0.03). Obese patients presented with fewer hip fractures (10% vs. 21%,
p
= 0.003) and more proximal humerus fractures (16% vs. 7%,
p
< 0.001) than non-obese patients. After adjusting for age, sex, and diabetes mellitus, BMD T-score values were significantly higher at all measurement sites (lumbar spine, total hip, and femoral neck) in obese patients than in non-obese patients for all types of fractures, with a mean difference of 1 standard deviation (
p
< 0.001 for all comparisons). The same results were observed in the population limited to MOF.
Conclusions
Given the crucial role of BMD T-score in determining the need for anti-osteoporotic medication following fragility fractures, it is reasonable to question the existing T-score thresholds in obese patients.
Graphical Abstract</description><identifier>ISSN: 1862-3514</identifier><identifier>EISSN: 1862-3514</identifier><identifier>DOI: 10.1007/s11657-024-01379-2</identifier><identifier>PMID: 38520592</identifier><language>eng</language><publisher>London: Springer London</publisher><subject>Absorptiometry, Photon - methods ; Aged ; Aged, 80 and over ; Bone Density ; bone fractures ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - epidemiology ; drug therapy ; Endocrinology ; Female ; females ; femur ; hips ; Humans ; humerus ; lumbar spine ; Lumbar Vertebrae ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; noninsulin-dependent diabetes mellitus ; Obesity - complications ; Obesity - epidemiology ; Original Article ; Orthopedics ; osteoporosis ; Osteoporotic Fractures - epidemiology ; Osteoporotic Fractures - etiology ; risk ; standard deviation</subject><ispartof>Archives of osteoporosis, 2024-03, Vol.19 (1), p.20-20, Article 20</ispartof><rights>International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. International Osteoporosis Foundation and Bone Health and Osteoporosis Foundation.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c331t-3a8260c1337f9593ffe4599679d065ba3f3973796f5f81757d73ebf6d29e316d3</cites><orcidid>0000-0001-6599-8623</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s11657-024-01379-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s11657-024-01379-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,41467,42536,51298</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38520592$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Marchasson, Gauthier</creatorcontrib><creatorcontrib>Philippoteaux, Cécile</creatorcontrib><creatorcontrib>Legroux-Gérot, Isabelle</creatorcontrib><creatorcontrib>Hélène, Béhal</creatorcontrib><creatorcontrib>Cortet, Bernard</creatorcontrib><creatorcontrib>Paccou, Julien</creatorcontrib><title>Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture</title><title>Archives of osteoporosis</title><addtitle>Arch Osteoporos</addtitle><addtitle>Arch Osteoporos</addtitle><description>Mini-abstract
We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a mean difference of 1 SD.
Purpose
This study aimed to compare the mean T-scores of obese and non-obese patients after recent fragility fractures.
Methods
Over a period of 5 and a half years, from January 2016 to May 2021, patients from a fracture liaison service were identified and their demographic characteristics, osteoporosis risk factors, BMD T-scores, and fracture sites were compared between obese (BMI ≥ 30 kg/m
2
) and non-obese (19 kg/m
2
< BMI < 30 kg/m
2
) patients.
Results
A total of 712 patients were included (80.1% women; mean age 73.8 ± 11.3 years). Sixteen % had type 2 diabetes mellitus and 80% had a major osteoporotic fracture (MOF). 135 patients were obese and 577 non-obese, with obese patients younger (
p
< 0.001) and more frequently female (
p
= 0.03). Obese patients presented with fewer hip fractures (10% vs. 21%,
p
= 0.003) and more proximal humerus fractures (16% vs. 7%,
p
< 0.001) than non-obese patients. After adjusting for age, sex, and diabetes mellitus, BMD T-score values were significantly higher at all measurement sites (lumbar spine, total hip, and femoral neck) in obese patients than in non-obese patients for all types of fractures, with a mean difference of 1 standard deviation (
p
< 0.001 for all comparisons). The same results were observed in the population limited to MOF.
Conclusions
Given the crucial role of BMD T-score in determining the need for anti-osteoporotic medication following fragility fractures, it is reasonable to question the existing T-score thresholds in obese patients.
Graphical Abstract</description><subject>Absorptiometry, Photon - methods</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Bone Density</subject><subject>bone fractures</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>drug therapy</subject><subject>Endocrinology</subject><subject>Female</subject><subject>females</subject><subject>femur</subject><subject>hips</subject><subject>Humans</subject><subject>humerus</subject><subject>lumbar spine</subject><subject>Lumbar Vertebrae</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>noninsulin-dependent diabetes mellitus</subject><subject>Obesity - complications</subject><subject>Obesity - epidemiology</subject><subject>Original Article</subject><subject>Orthopedics</subject><subject>osteoporosis</subject><subject>Osteoporotic Fractures - epidemiology</subject><subject>Osteoporotic Fractures - etiology</subject><subject>risk</subject><subject>standard deviation</subject><issn>1862-3514</issn><issn>1862-3514</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc9uFSEYxSdGY2v1BVwYlm6o_BlgWGrTWpObuLCuCQMfNzQzcIWZNn0Y31XauRpXuuIQfueQnNN1byk5p4SoD5VSKRQmrMeEcqUxe9ad0kEyzAXtn_-lT7pXtd4SIgkV8mV3wgfBiNDstPv5KSdAc0xQ7IQ8pBqXB3SDq8sFKnJ5PtgSa05ohOUeIKE8QgVkk0cpJ7zdYvLxLvrVTrVpN60efBPIoqti3bIWQLton2K-QbmLDlDI05TvY9o3qICDtKBQ7D5Oj_-Ho-t19yK0THhzPM-671eXNxfXePf185eLjzvsOKcL5nZgkjjKuQpaaB4C9EJrqbQnUoyWB65VK0gGEQaqhPKKwxikZxo4lZ6fde-33EPJP1aoi5ljdTBNNkFeq-FUcMn6QfP_okyrvhXNhWwo21BXcq0FgjmUONvyYCgxjwuabUHTFjRPCxrWTO-O-es4g_9j-T1ZA_gG1PaU9lDMbV5LavX8K_YXavaojA</recordid><startdate>20240323</startdate><enddate>20240323</enddate><creator>Marchasson, Gauthier</creator><creator>Philippoteaux, Cécile</creator><creator>Legroux-Gérot, Isabelle</creator><creator>Hélène, Béhal</creator><creator>Cortet, Bernard</creator><creator>Paccou, Julien</creator><general>Springer London</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0001-6599-8623</orcidid></search><sort><creationdate>20240323</creationdate><title>Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture</title><author>Marchasson, Gauthier ; Philippoteaux, Cécile ; Legroux-Gérot, Isabelle ; Hélène, Béhal ; Cortet, Bernard ; Paccou, Julien</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c331t-3a8260c1337f9593ffe4599679d065ba3f3973796f5f81757d73ebf6d29e316d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Absorptiometry, Photon - methods</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Bone Density</topic><topic>bone fractures</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>drug therapy</topic><topic>Endocrinology</topic><topic>Female</topic><topic>females</topic><topic>femur</topic><topic>hips</topic><topic>Humans</topic><topic>humerus</topic><topic>lumbar spine</topic><topic>Lumbar Vertebrae</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>noninsulin-dependent diabetes mellitus</topic><topic>Obesity - complications</topic><topic>Obesity - epidemiology</topic><topic>Original Article</topic><topic>Orthopedics</topic><topic>osteoporosis</topic><topic>Osteoporotic Fractures - epidemiology</topic><topic>Osteoporotic Fractures - etiology</topic><topic>risk</topic><topic>standard deviation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Marchasson, Gauthier</creatorcontrib><creatorcontrib>Philippoteaux, Cécile</creatorcontrib><creatorcontrib>Legroux-Gérot, Isabelle</creatorcontrib><creatorcontrib>Hélène, Béhal</creatorcontrib><creatorcontrib>Cortet, Bernard</creatorcontrib><creatorcontrib>Paccou, Julien</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Archives of osteoporosis</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Marchasson, Gauthier</au><au>Philippoteaux, Cécile</au><au>Legroux-Gérot, Isabelle</au><au>Hélène, Béhal</au><au>Cortet, Bernard</au><au>Paccou, Julien</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture</atitle><jtitle>Archives of osteoporosis</jtitle><stitle>Arch Osteoporos</stitle><addtitle>Arch Osteoporos</addtitle><date>2024-03-23</date><risdate>2024</risdate><volume>19</volume><issue>1</issue><spage>20</spage><epage>20</epage><pages>20-20</pages><artnum>20</artnum><issn>1862-3514</issn><eissn>1862-3514</eissn><abstract>Mini-abstract
We used data from a Fracture Liaison Service to compare the mean T-scores of obese and non-obese patients after a recent fragility fracture. After adjusting for age, sex, and diabetes mellitus, T-score values were significantly higher at all measurement sites in obese patients, with a mean difference of 1 SD.
Purpose
This study aimed to compare the mean T-scores of obese and non-obese patients after recent fragility fractures.
Methods
Over a period of 5 and a half years, from January 2016 to May 2021, patients from a fracture liaison service were identified and their demographic characteristics, osteoporosis risk factors, BMD T-scores, and fracture sites were compared between obese (BMI ≥ 30 kg/m
2
) and non-obese (19 kg/m
2
< BMI < 30 kg/m
2
) patients.
Results
A total of 712 patients were included (80.1% women; mean age 73.8 ± 11.3 years). Sixteen % had type 2 diabetes mellitus and 80% had a major osteoporotic fracture (MOF). 135 patients were obese and 577 non-obese, with obese patients younger (
p
< 0.001) and more frequently female (
p
= 0.03). Obese patients presented with fewer hip fractures (10% vs. 21%,
p
= 0.003) and more proximal humerus fractures (16% vs. 7%,
p
< 0.001) than non-obese patients. After adjusting for age, sex, and diabetes mellitus, BMD T-score values were significantly higher at all measurement sites (lumbar spine, total hip, and femoral neck) in obese patients than in non-obese patients for all types of fractures, with a mean difference of 1 standard deviation (
p
< 0.001 for all comparisons). The same results were observed in the population limited to MOF.
Conclusions
Given the crucial role of BMD T-score in determining the need for anti-osteoporotic medication following fragility fractures, it is reasonable to question the existing T-score thresholds in obese patients.
Graphical Abstract</abstract><cop>London</cop><pub>Springer London</pub><pmid>38520592</pmid><doi>10.1007/s11657-024-01379-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0001-6599-8623</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1862-3514 |
| ispartof | Archives of osteoporosis, 2024-03, Vol.19 (1), p.20-20, Article 20 |
| issn | 1862-3514 1862-3514 |
| language | eng |
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| source | MEDLINE; SpringerLink |
| subjects | Absorptiometry, Photon - methods Aged Aged, 80 and over Bone Density bone fractures Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - epidemiology drug therapy Endocrinology Female females femur hips Humans humerus lumbar spine Lumbar Vertebrae Male Medicine Medicine & Public Health Middle Aged noninsulin-dependent diabetes mellitus Obesity - complications Obesity - epidemiology Original Article Orthopedics osteoporosis Osteoporotic Fractures - epidemiology Osteoporotic Fractures - etiology risk standard deviation |
| title | Bone mineral density T-scores comparison between obese and non-obese individuals included in a Fracture Liaison Service following a recent fragility fracture |
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