Mitochondria targeted drug delivery system overcoming drug resistance in intrahepatic cholangiocarcinoma by reprogramming lipid metabolism

The challenge of drug resistance in intrahepatic cholangiocarcinoma (ICC) is intricately linked with lipid metabolism reprogramming. The hepatic lipase (HL) and the membrane receptor CD36 are overexpressed in BGJ398-resistant ICC cells, while they are essential for lipid uptake, further enhancing li...

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Veröffentlicht in:	Biomaterials 2024-09, Vol.309, p.122609, Article 122609
Hauptverfasser:	Duan, Yi, Deng, Mengqiong, Liu, Bin, Meng, Xianwei, Liao, Jinghan, Qiu, Yijie, Wu, Zhihua, Lin, Jiangtao, Dong, Yi, Duan, Yourong, Sun, Ying
Format:	Artikel
Sprache:	eng
Schlagworte:	biocompatible materials carboxylic ester hydrolases Drug delivery system drug delivery systems Drug resistance drugs energy immune response Intrahepatic cholangiocarcinoma Lipid metabolism lipids mitochondria Mitochondria targeting monoclonal antibodies neoplasms reactive oxygen species
Online-Zugang:	Volltext
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