Comparative analysis of optical coherence tomography angiography (OCTA) results between Behçet’s disease patients and a healthy control group
Purpose This study aimed to compare optical coherence tomography angiography (OCTA) findings between patients with Behçet’s disease (BD) and individuals with healthy eyes. Design A cross-sectional study. Methods This cross-sectional study was conducted on patients (67 eyes) with BD who were referred...
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| Veröffentlicht in: | Clinical rheumatology 2024-03, Vol.43 (3), p.1155-1170 |
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| creator | Kianersi, Farzan Bazvand, Masoumeh Fatemi, Alimohammad Naderi Beni, Afsaneh Kianersi, Hamidreza |
| description | Purpose
This study aimed to compare optical coherence tomography angiography (OCTA) findings between patients with Behçet’s disease (BD) and individuals with healthy eyes.
Design
A cross-sectional study.
Methods
This cross-sectional study was conducted on patients (67 eyes) with BD who were referred to Feiz Hospital and healthy eyes (43 eyes). All subjects underwent Snellen visual acuity, a slit-lamp examination, measuring intraocular pressure, conducting a dilated fundus examination, OCTA imaging, and spectral-domain (SD)-OCT imaging. OCTA retinal vascular measurements including optic nerve VD, macular-associated VD( superficial and deep), foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), and vessel density within a 300-μm-wide region of the FAZ (FD) were compared between the groups.
Results
A significant difference was evident between the two groups (healthy one group and BD group) in terms of parafoveal and perifoveal total retinal thickness, total pRNFL VD in all quadrants except the inferior sector (
P
|
| doi_str_mv | 10.1007/s10067-024-06874-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153621256</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2928413987</sourcerecordid><originalsourceid>FETCH-LOGICAL-c359t-c42d69ac3a8739c549272101a7f426706942f3c67cf5da4e841d7f34289e39ec3</originalsourceid><addsrcrecordid>eNqFkU9u1TAQhy1ERR8PLsACWWJTFin-lzhelqcWkCp1U9bW1Jm8lyqJg-2AsuMIbDlBD9KbcBJcXgsSC9jYlvzNb0bzEfKCs2POmH4T81npgglVsKrWqlgekRVXUhXGKPOYrJjWrJDc1IfkaYzXjDFRG_6EHMpa1KXUYkW-bfwwQYDUfUYKI_RL7CL1LfVT6hz01PkdBhwd0uQHvw0w7ZYMbruH99HF5vLkNQ0Y5z5FeoXpC-JI3-Lu9gbTj6_fI226iBCRTrkNjhmCsaFAdwh9ygnOjyn4nm6Dn6dn5KCFPuLz-3tNPp6dXm7eF-cX7z5sTs4LJ0uTCqdEUxlwEmotjSuVEVpwxkG3SlSaVUaJVrpKu7ZsQGGteKNbqfICUBp0ck2O9rlT8J9mjMkOXXTY9zCin6OVvJSV4KKs_osKw41WJZMmo6_-Qq_9HPJa7yiRh5Amz7smYk-54GMM2NopdAOExXJm79TavVqb1dpfau2Si17eR89XAza_Sx5cZkDugZi_xi2GP73_EfsTxBux_w</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2928413987</pqid></control><display><type>article</type><title>Comparative analysis of optical coherence tomography angiography (OCTA) results between Behçet’s disease patients and a healthy control group</title><source>Springer Nature - Complete Springer Journals</source><creator>Kianersi, Farzan ; Bazvand, Masoumeh ; Fatemi, Alimohammad ; Naderi Beni, Afsaneh ; Kianersi, Hamidreza</creator><creatorcontrib>Kianersi, Farzan ; Bazvand, Masoumeh ; Fatemi, Alimohammad ; Naderi Beni, Afsaneh ; Kianersi, Hamidreza</creatorcontrib><description>Purpose
This study aimed to compare optical coherence tomography angiography (OCTA) findings between patients with Behçet’s disease (BD) and individuals with healthy eyes.
Design
A cross-sectional study.
Methods
This cross-sectional study was conducted on patients (67 eyes) with BD who were referred to Feiz Hospital and healthy eyes (43 eyes). All subjects underwent Snellen visual acuity, a slit-lamp examination, measuring intraocular pressure, conducting a dilated fundus examination, OCTA imaging, and spectral-domain (SD)-OCT imaging. OCTA retinal vascular measurements including optic nerve VD, macular-associated VD( superficial and deep), foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), and vessel density within a 300-μm-wide region of the FAZ (FD) were compared between the groups.
Results
A significant difference was evident between the two groups (healthy one group and BD group) in terms of parafoveal and perifoveal total retinal thickness, total pRNFL VD in all quadrants except the inferior sector (
P
< 0.05), and macular superficial, and deep VD in all regions except temporal and superior perifoveal VD (
P
< 0.05) following adjustments for age, gender, and signal strength index. When comparing the two groups, ocular Behçet’s disease (BD) and non-ocular BD, it was evident that peripapillary vessel density (VD) exhibited a significant decrease in ocular BD eyes in all sectors except for the superior and inferior ones, as compared to non-ocular BD eyes. In addition, the comparison of ocular BD and non-ocular BD showed superficial and deep VDs were lower in ocular BD than non-ocular BD in all regions.
Conclusion
According to these findings, peripapillary and macular vessel density is affected in BD.
Key Points
• The study utilized OCTA to compare retinal features in Behçet’s disease (BD) patients and healthy individuals, revealing significant differences in retinal thickness and vessel density.
• Ocular BD demonstrated reduced peripapillary vessel density compared to non-ocular BD.
• The demonstrated association between ADMA and cIMT in patients with early SSc may suggest a role of NO/ADMA pathway in the initiation of macrovascular injury in SSc.</description><identifier>ISSN: 0770-3198</identifier><identifier>EISSN: 1434-9949</identifier><identifier>DOI: 10.1007/s10067-024-06874-y</identifier><identifier>PMID: 38285372</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Acuity ; Angiography ; Behcet's syndrome ; Comparative analysis ; Cross-sectional studies ; Eye diseases ; gender ; hospitals ; Medical imaging ; Medicine ; Medicine & Public Health ; nerve tissue ; Optic nerve ; Original Article ; Retina ; Rheumatology ; Sexually transmitted diseases ; signal strength ; STD ; Tomography ; Vein & artery diseases</subject><ispartof>Clinical rheumatology, 2024-03, Vol.43 (3), p.1155-1170</ispartof><rights>The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR).</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c359t-c42d69ac3a8739c549272101a7f426706942f3c67cf5da4e841d7f34289e39ec3</cites><orcidid>0000-0002-0609-9430</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10067-024-06874-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10067-024-06874-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38285372$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kianersi, Farzan</creatorcontrib><creatorcontrib>Bazvand, Masoumeh</creatorcontrib><creatorcontrib>Fatemi, Alimohammad</creatorcontrib><creatorcontrib>Naderi Beni, Afsaneh</creatorcontrib><creatorcontrib>Kianersi, Hamidreza</creatorcontrib><title>Comparative analysis of optical coherence tomography angiography (OCTA) results between Behçet’s disease patients and a healthy control group</title><title>Clinical rheumatology</title><addtitle>Clin Rheumatol</addtitle><addtitle>Clin Rheumatol</addtitle><description>Purpose
This study aimed to compare optical coherence tomography angiography (OCTA) findings between patients with Behçet’s disease (BD) and individuals with healthy eyes.
Design
A cross-sectional study.
Methods
This cross-sectional study was conducted on patients (67 eyes) with BD who were referred to Feiz Hospital and healthy eyes (43 eyes). All subjects underwent Snellen visual acuity, a slit-lamp examination, measuring intraocular pressure, conducting a dilated fundus examination, OCTA imaging, and spectral-domain (SD)-OCT imaging. OCTA retinal vascular measurements including optic nerve VD, macular-associated VD( superficial and deep), foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), and vessel density within a 300-μm-wide region of the FAZ (FD) were compared between the groups.
Results
A significant difference was evident between the two groups (healthy one group and BD group) in terms of parafoveal and perifoveal total retinal thickness, total pRNFL VD in all quadrants except the inferior sector (
P
< 0.05), and macular superficial, and deep VD in all regions except temporal and superior perifoveal VD (
P
< 0.05) following adjustments for age, gender, and signal strength index. When comparing the two groups, ocular Behçet’s disease (BD) and non-ocular BD, it was evident that peripapillary vessel density (VD) exhibited a significant decrease in ocular BD eyes in all sectors except for the superior and inferior ones, as compared to non-ocular BD eyes. In addition, the comparison of ocular BD and non-ocular BD showed superficial and deep VDs were lower in ocular BD than non-ocular BD in all regions.
Conclusion
According to these findings, peripapillary and macular vessel density is affected in BD.
Key Points
• The study utilized OCTA to compare retinal features in Behçet’s disease (BD) patients and healthy individuals, revealing significant differences in retinal thickness and vessel density.
• Ocular BD demonstrated reduced peripapillary vessel density compared to non-ocular BD.
• The demonstrated association between ADMA and cIMT in patients with early SSc may suggest a role of NO/ADMA pathway in the initiation of macrovascular injury in SSc.</description><subject>Acuity</subject><subject>Angiography</subject><subject>Behcet's syndrome</subject><subject>Comparative analysis</subject><subject>Cross-sectional studies</subject><subject>Eye diseases</subject><subject>gender</subject><subject>hospitals</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>nerve tissue</subject><subject>Optic nerve</subject><subject>Original Article</subject><subject>Retina</subject><subject>Rheumatology</subject><subject>Sexually transmitted diseases</subject><subject>signal strength</subject><subject>STD</subject><subject>Tomography</subject><subject>Vein & artery diseases</subject><issn>0770-3198</issn><issn>1434-9949</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkU9u1TAQhy1ERR8PLsACWWJTFin-lzhelqcWkCp1U9bW1Jm8lyqJg-2AsuMIbDlBD9KbcBJcXgsSC9jYlvzNb0bzEfKCs2POmH4T81npgglVsKrWqlgekRVXUhXGKPOYrJjWrJDc1IfkaYzXjDFRG_6EHMpa1KXUYkW-bfwwQYDUfUYKI_RL7CL1LfVT6hz01PkdBhwd0uQHvw0w7ZYMbruH99HF5vLkNQ0Y5z5FeoXpC-JI3-Lu9gbTj6_fI226iBCRTrkNjhmCsaFAdwh9ygnOjyn4nm6Dn6dn5KCFPuLz-3tNPp6dXm7eF-cX7z5sTs4LJ0uTCqdEUxlwEmotjSuVEVpwxkG3SlSaVUaJVrpKu7ZsQGGteKNbqfICUBp0ck2O9rlT8J9mjMkOXXTY9zCin6OVvJSV4KKs_osKw41WJZMmo6_-Qq_9HPJa7yiRh5Amz7smYk-54GMM2NopdAOExXJm79TavVqb1dpfau2Si17eR89XAza_Sx5cZkDugZi_xi2GP73_EfsTxBux_w</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Kianersi, Farzan</creator><creator>Bazvand, Masoumeh</creator><creator>Fatemi, Alimohammad</creator><creator>Naderi Beni, Afsaneh</creator><creator>Kianersi, Hamidreza</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-0609-9430</orcidid></search><sort><creationdate>20240301</creationdate><title>Comparative analysis of optical coherence tomography angiography (OCTA) results between Behçet’s disease patients and a healthy control group</title><author>Kianersi, Farzan ; Bazvand, Masoumeh ; Fatemi, Alimohammad ; Naderi Beni, Afsaneh ; Kianersi, Hamidreza</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c359t-c42d69ac3a8739c549272101a7f426706942f3c67cf5da4e841d7f34289e39ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Acuity</topic><topic>Angiography</topic><topic>Behcet's syndrome</topic><topic>Comparative analysis</topic><topic>Cross-sectional studies</topic><topic>Eye diseases</topic><topic>gender</topic><topic>hospitals</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>nerve tissue</topic><topic>Optic nerve</topic><topic>Original Article</topic><topic>Retina</topic><topic>Rheumatology</topic><topic>Sexually transmitted diseases</topic><topic>signal strength</topic><topic>STD</topic><topic>Tomography</topic><topic>Vein & artery diseases</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kianersi, Farzan</creatorcontrib><creatorcontrib>Bazvand, Masoumeh</creatorcontrib><creatorcontrib>Fatemi, Alimohammad</creatorcontrib><creatorcontrib>Naderi Beni, Afsaneh</creatorcontrib><creatorcontrib>Kianersi, Hamidreza</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Clinical rheumatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kianersi, Farzan</au><au>Bazvand, Masoumeh</au><au>Fatemi, Alimohammad</au><au>Naderi Beni, Afsaneh</au><au>Kianersi, Hamidreza</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative analysis of optical coherence tomography angiography (OCTA) results between Behçet’s disease patients and a healthy control group</atitle><jtitle>Clinical rheumatology</jtitle><stitle>Clin Rheumatol</stitle><addtitle>Clin Rheumatol</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>43</volume><issue>3</issue><spage>1155</spage><epage>1170</epage><pages>1155-1170</pages><issn>0770-3198</issn><eissn>1434-9949</eissn><abstract>Purpose
This study aimed to compare optical coherence tomography angiography (OCTA) findings between patients with Behçet’s disease (BD) and individuals with healthy eyes.
Design
A cross-sectional study.
Methods
This cross-sectional study was conducted on patients (67 eyes) with BD who were referred to Feiz Hospital and healthy eyes (43 eyes). All subjects underwent Snellen visual acuity, a slit-lamp examination, measuring intraocular pressure, conducting a dilated fundus examination, OCTA imaging, and spectral-domain (SD)-OCT imaging. OCTA retinal vascular measurements including optic nerve VD, macular-associated VD( superficial and deep), foveal avascular zone (FAZ) area, FAZ perimeter (PERIM), and vessel density within a 300-μm-wide region of the FAZ (FD) were compared between the groups.
Results
A significant difference was evident between the two groups (healthy one group and BD group) in terms of parafoveal and perifoveal total retinal thickness, total pRNFL VD in all quadrants except the inferior sector (
P
< 0.05), and macular superficial, and deep VD in all regions except temporal and superior perifoveal VD (
P
< 0.05) following adjustments for age, gender, and signal strength index. When comparing the two groups, ocular Behçet’s disease (BD) and non-ocular BD, it was evident that peripapillary vessel density (VD) exhibited a significant decrease in ocular BD eyes in all sectors except for the superior and inferior ones, as compared to non-ocular BD eyes. In addition, the comparison of ocular BD and non-ocular BD showed superficial and deep VDs were lower in ocular BD than non-ocular BD in all regions.
Conclusion
According to these findings, peripapillary and macular vessel density is affected in BD.
Key Points
• The study utilized OCTA to compare retinal features in Behçet’s disease (BD) patients and healthy individuals, revealing significant differences in retinal thickness and vessel density.
• Ocular BD demonstrated reduced peripapillary vessel density compared to non-ocular BD.
• The demonstrated association between ADMA and cIMT in patients with early SSc may suggest a role of NO/ADMA pathway in the initiation of macrovascular injury in SSc.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>38285372</pmid><doi>10.1007/s10067-024-06874-y</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0002-0609-9430</orcidid></addata></record> |
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| ispartof | Clinical rheumatology, 2024-03, Vol.43 (3), p.1155-1170 |
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| language | eng |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Acuity Angiography Behcet's syndrome Comparative analysis Cross-sectional studies Eye diseases gender hospitals Medical imaging Medicine Medicine & Public Health nerve tissue Optic nerve Original Article Retina Rheumatology Sexually transmitted diseases signal strength STD Tomography Vein & artery diseases |
| title | Comparative analysis of optical coherence tomography angiography (OCTA) results between Behçet’s disease patients and a healthy control group |
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