KIT-SNAP-tag/cell membrane chromatography model coupled with liquid chromatography–mass spectrometry for anti-GIST compound screening from Evodia rutaecarpa

Gastrointestinal mesenchymal tumors, as the most common mesenchymal tumors in the gastrointestinal tract, are adjuvantly treated with multi-targeted tyrosine kinase inhibitors, such as imatinib and sunitinib, but there are problems of drug resistance and complex methods of monitoring therapeutic age...

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Veröffentlicht in:	Analytical and bioanalytical chemistry 2024-03, Vol.416 (6), p.1457-1468
Hauptverfasser:	Feng, Jingting, Jiang, Yuhan, Liu, Sihan, Deng, Linge, Lv, Yanni, Chen, Nanzheng, Han, Shengli
Format:	Artikel
Sprache:	eng
Schlagworte:	Analytical Chemistry antineoplastic agents Antitumor agents Biochemistry Cell membranes Cell proliferation Characterization and Evaluation of Materials Chemical bonds Chemistry Chemistry and Materials Science Chemotherapy Chinese medicine Chromatography Column chromatography Complex systems digestive tract Drug resistance Drug therapy Enzyme inhibitors Euodia Evodia rutaecarpa Food Science Gastrointestinal system Gastrointestinal tract Growth factors Herbal medicine High performance liquid chromatography Imatinib Kinases Laboratory Medicine Liquid chromatography Mass spectrometry Mass spectroscopy Monitoring methods Monitoring/Environmental Analysis Oriental traditional medicine Pathogenesis Pharmacology Platelet-derived growth factor Platelet-derived growth factor receptors Research Paper Silica Silica gel tetrazolium Traditional Chinese medicine Tumors Tyrosine Tyrosine kinase inhibitors
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