Isoglutaminyl Cyclase Overexpression Enhances KYSE30 Cancer Cell Proliferation and Migration via the MAPK Signaling Pathway

To understand how upregulated isoglutaminyl cyclase (isoQC) is involved in the initiation of diseases such as cancer, we developed a human KYSE30 carcinoma cell model in which isoQC was stably overexpressed. GO and KEGG analysis of the DEGs (228) and DEPs (254) respectively implicated isoQC on the p...

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Veröffentlicht in:	Journal of proteome research 2024-05, Vol.23 (5), p.1859-1870
Hauptverfasser:	Chen, Xiaojie, Yu, Xi, Cui, Yangqing, Du, Lang, Zhou, Qingqing, Xiong, Wei, Li, Chenyang, Xu, Chenshu, Wu, Haiqiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoacyltransferases Cell Line, Tumor Cell Movement - genetics cell proliferation Cell Proliferation - genetics circadian rhythm Gene Expression Regulation, Neoplastic Humans MAP Kinase Signaling System - genetics metastasis neoplasm cells Neoplasm Invasiveness Neoplasms - genetics Neoplasms - metabolism Neoplasms - pathology Period Circadian Proteins - genetics Period Circadian Proteins - metabolism proteome RNA sequence analysis Up-Regulation
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