Molecular Machines For The Control Of Transmembrane Transport
Nature embeds some of its molecular machinery, including ion pumps, within lipid bilayer membranes. This has inspired chemists to attempt to develop synthetic analogues to exploit membrane confinement and transmembrane potential gradients, much like their biological cousins. In this perspective, we...
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| Veröffentlicht in: | Journal of the American Chemical Society 2023-12, Vol.145 (50), p.27167-27184 |
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| container_end_page | 27184 |
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| container_issue | 50 |
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| container_title | Journal of the American Chemical Society |
| container_volume | 145 |
| creator | Johnson, Toby G. Langton, Matthew J. |
| description | Nature embeds some of its molecular machinery, including ion pumps, within lipid bilayer membranes. This has inspired chemists to attempt to develop synthetic analogues to exploit membrane confinement and transmembrane potential gradients, much like their biological cousins. In this perspective, we outline the various strategies by which molecular machinesmolecular systems in which a nanomechanical motion is exploited for functionhave been designed to be incorporated within lipid membranes and utilized to mediate transmembrane ion transport. We survey molecular machines spanning both switches and motors, those that act as mobile carriers or that are anchored within the membrane, mechanically interlocked molecules, and examples that are activated in response to external stimuli. |
| doi_str_mv | 10.1021/jacs.3c08877 |
| format | Article |
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| fulltext | fulltext |
| identifier | ISSN: 0002-7863 |
| ispartof | Journal of the American Chemical Society, 2023-12, Vol.145 (50), p.27167-27184 |
| issn | 0002-7863 1520-5126 1520-5126 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153617458 |
| source | American Chemical Society Journals |
| subjects | lipid bilayers lipids membrane potential |
| title | Molecular Machines For The Control Of Transmembrane Transport |
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