Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs
•Multiomic study of the protective mechanism of P. capitata in streptozotocin-treated DN pig. Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross (P. capitata, PCB), a traditional drug of the Miao people in China, is potential traditional drug used for the treatment of diabetic nephropathy (DN). The p...
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| Veröffentlicht in: | Phytomedicine (Stuttgart) 2024-06, Vol.128, p.155499-155499, Article 155499 |
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| creator | Wu, Yanjun Mo, Jiayuan Liang, Jing Pu, Xiang Dong, Yuanqiu Zhu, Xiang Zhao, Hai Qiu, Huaming Wu, Shuguang Lu, Taofeng |
| description | •Multiomic study of the protective mechanism of P. capitata in streptozotocin-treated DN pig.
Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross (P. capitata, PCB), a traditional drug of the Miao people in China, is potential traditional drug used for the treatment of diabetic nephropathy (DN).
The purpose of this study is to investigate the function of P. capitata and clarify its protective mechanism against DN.
We induced DN in the Guizhou miniature pig with injections of streptozotocin, and P. capitata was added to the pigs’ diet to treat DN. In week 16, all the animals were slaughtered, samples were collected, and the relative DN indices were measured. 16S rRNA sequencing, metagenomics, metabolomics, RNA sequencing, and proteomics were used to explore the protective mechanism of P. capitata against DN.
Dietary supplementation with P. capitata significantly reduced the extent of the disease, not only in term of the relative disease indices but also in hematoxylin-eosin-stained tissues. A multiomic analysis showed that two microbes (Clostridium baratii and Escherichia coli), five metabolites (oleic acid, linoleic acid, 4-phenylbutyric acid, 18-β-glycyrrhetinic acid, and ergosterol peroxide), four proteins (ENTPD5, EPHX1, ARVCF and TREH), four important mRNAs (encoding ENTPD5, EPHX1, ARVCF, and TREH), six lncRNAs (TCONS_00024194, TCONS_00085825, TCONS_00006937, TCONS_00070981, TCONS_00074099, and TCONS_00097913), and two circRNAs (novel_circ_0001514 and novel_circ_0017507) are all involved in the protective mechanism of P. capitata against DN.
Our results provide multidimensional theoretical support for the study and application of P. capitata.
[Display omitted] |
| doi_str_mv | 10.1016/j.phymed.2024.155499 |
| format | Article |
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Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross (P. capitata, PCB), a traditional drug of the Miao people in China, is potential traditional drug used for the treatment of diabetic nephropathy (DN).
The purpose of this study is to investigate the function of P. capitata and clarify its protective mechanism against DN.
We induced DN in the Guizhou miniature pig with injections of streptozotocin, and P. capitata was added to the pigs’ diet to treat DN. In week 16, all the animals were slaughtered, samples were collected, and the relative DN indices were measured. 16S rRNA sequencing, metagenomics, metabolomics, RNA sequencing, and proteomics were used to explore the protective mechanism of P. capitata against DN.
Dietary supplementation with P. capitata significantly reduced the extent of the disease, not only in term of the relative disease indices but also in hematoxylin-eosin-stained tissues. A multiomic analysis showed that two microbes (Clostridium baratii and Escherichia coli), five metabolites (oleic acid, linoleic acid, 4-phenylbutyric acid, 18-β-glycyrrhetinic acid, and ergosterol peroxide), four proteins (ENTPD5, EPHX1, ARVCF and TREH), four important mRNAs (encoding ENTPD5, EPHX1, ARVCF, and TREH), six lncRNAs (TCONS_00024194, TCONS_00085825, TCONS_00006937, TCONS_00070981, TCONS_00074099, and TCONS_00097913), and two circRNAs (novel_circ_0001514 and novel_circ_0017507) are all involved in the protective mechanism of P. capitata against DN.
Our results provide multidimensional theoretical support for the study and application of P. capitata.
[Display omitted]</description><identifier>ISSN: 0944-7113</identifier><identifier>EISSN: 1618-095X</identifier><identifier>DOI: 10.1016/j.phymed.2024.155499</identifier><identifier>PMID: 38492367</identifier><language>eng</language><publisher>Germany: Elsevier GmbH</publisher><subject>China ; Clostridium baratii ; Diabetic nephropathy ; dietary supplements ; drugs ; ergosterol ; Escherichia coli ; Guizhou miniature pig ; linoleic acid ; metabolites ; metabolomics ; metagenomics ; miniature swine ; Multiomic analysis ; oleic acid ; people ; Persicaria capitata ; Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross ; proteomics ; RNA ; Streptozotocin</subject><ispartof>Phytomedicine (Stuttgart), 2024-06, Vol.128, p.155499-155499, Article 155499</ispartof><rights>2024 Elsevier GmbH</rights><rights>Copyright © 2024 Elsevier GmbH. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c344t-30105a96b6d277e34155041cdeefa2e622e7f25fc351e2877cc6954cdaa7abeb3</cites><orcidid>0000-0003-1550-5135 ; 0000-0001-5881-905X ; 0000-0002-4379-8230</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0944711324001636$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38492367$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Yanjun</creatorcontrib><creatorcontrib>Mo, Jiayuan</creatorcontrib><creatorcontrib>Liang, Jing</creatorcontrib><creatorcontrib>Pu, Xiang</creatorcontrib><creatorcontrib>Dong, Yuanqiu</creatorcontrib><creatorcontrib>Zhu, Xiang</creatorcontrib><creatorcontrib>Zhao, Hai</creatorcontrib><creatorcontrib>Qiu, Huaming</creatorcontrib><creatorcontrib>Wu, Shuguang</creatorcontrib><creatorcontrib>Lu, Taofeng</creatorcontrib><title>Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs</title><title>Phytomedicine (Stuttgart)</title><addtitle>Phytomedicine</addtitle><description>•Multiomic study of the protective mechanism of P. capitata in streptozotocin-treated DN pig.
Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross (P. capitata, PCB), a traditional drug of the Miao people in China, is potential traditional drug used for the treatment of diabetic nephropathy (DN).
The purpose of this study is to investigate the function of P. capitata and clarify its protective mechanism against DN.
We induced DN in the Guizhou miniature pig with injections of streptozotocin, and P. capitata was added to the pigs’ diet to treat DN. In week 16, all the animals were slaughtered, samples were collected, and the relative DN indices were measured. 16S rRNA sequencing, metagenomics, metabolomics, RNA sequencing, and proteomics were used to explore the protective mechanism of P. capitata against DN.
Dietary supplementation with P. capitata significantly reduced the extent of the disease, not only in term of the relative disease indices but also in hematoxylin-eosin-stained tissues. A multiomic analysis showed that two microbes (Clostridium baratii and Escherichia coli), five metabolites (oleic acid, linoleic acid, 4-phenylbutyric acid, 18-β-glycyrrhetinic acid, and ergosterol peroxide), four proteins (ENTPD5, EPHX1, ARVCF and TREH), four important mRNAs (encoding ENTPD5, EPHX1, ARVCF, and TREH), six lncRNAs (TCONS_00024194, TCONS_00085825, TCONS_00006937, TCONS_00070981, TCONS_00074099, and TCONS_00097913), and two circRNAs (novel_circ_0001514 and novel_circ_0017507) are all involved in the protective mechanism of P. capitata against DN.
Our results provide multidimensional theoretical support for the study and application of P. capitata.
[Display omitted]</description><subject>China</subject><subject>Clostridium baratii</subject><subject>Diabetic nephropathy</subject><subject>dietary supplements</subject><subject>drugs</subject><subject>ergosterol</subject><subject>Escherichia coli</subject><subject>Guizhou miniature pig</subject><subject>linoleic acid</subject><subject>metabolites</subject><subject>metabolomics</subject><subject>metagenomics</subject><subject>miniature swine</subject><subject>Multiomic analysis</subject><subject>oleic acid</subject><subject>people</subject><subject>Persicaria capitata</subject><subject>Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross</subject><subject>proteomics</subject><subject>RNA</subject><subject>Streptozotocin</subject><issn>0944-7113</issn><issn>1618-095X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkc1u1DAUhSMEokPhDRDysiwSbMf58QaJtjCDVAQLkNhZHuemuaNJHPxTMX0onhFHabewuot7zj1X58uy14wWjLL63aGYh9MIXcEpFwWrKiHlk2zDatbmVFY_n2YbKoXIG8bKs-yF9wdKmZANfZ6dla2QvKybTfbnSzwGtCMa4kPsTsT2JAxAZmcDmIB3QEYwg57Qj8vuGziPRjvUxOgZgw6aXFxGMxT5To8Fgd_kuri201uyK7bOek_0rcbJh3TewRzsvQ3W4JTj1EUDHelQ7yGk-AnmwdlZh-FEcCLbiPeDjWTECXWILr2Et_5l9qzXRw-vHuZ59uPTx-9Xu_zm6_bz1Yeb3JRChLykjFZa1vu6400DpUj1UMFMB9BrDjXn0PS86k1ZMeBt0xhTy0qYTusmvbMvz7OL9W7q4VcEH9SI3sDxqCew0auSVWXN6kaK_0q5rFouWVstUrFKzdKMg17NDkftTopRtUBVB7VCVQtUtUJNtjcPCXG_7B5NjxST4P0qgFTJHYJT3iBMqV50CaLqLP474S96DrgZ</recordid><startdate>20240601</startdate><enddate>20240601</enddate><creator>Wu, Yanjun</creator><creator>Mo, Jiayuan</creator><creator>Liang, Jing</creator><creator>Pu, Xiang</creator><creator>Dong, Yuanqiu</creator><creator>Zhu, Xiang</creator><creator>Zhao, Hai</creator><creator>Qiu, Huaming</creator><creator>Wu, Shuguang</creator><creator>Lu, Taofeng</creator><general>Elsevier GmbH</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0003-1550-5135</orcidid><orcidid>https://orcid.org/0000-0001-5881-905X</orcidid><orcidid>https://orcid.org/0000-0002-4379-8230</orcidid></search><sort><creationdate>20240601</creationdate><title>Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs</title><author>Wu, Yanjun ; Mo, Jiayuan ; Liang, Jing ; Pu, Xiang ; Dong, Yuanqiu ; Zhu, Xiang ; Zhao, Hai ; Qiu, Huaming ; Wu, Shuguang ; Lu, Taofeng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c344t-30105a96b6d277e34155041cdeefa2e622e7f25fc351e2877cc6954cdaa7abeb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>China</topic><topic>Clostridium baratii</topic><topic>Diabetic nephropathy</topic><topic>dietary supplements</topic><topic>drugs</topic><topic>ergosterol</topic><topic>Escherichia coli</topic><topic>Guizhou miniature pig</topic><topic>linoleic acid</topic><topic>metabolites</topic><topic>metabolomics</topic><topic>metagenomics</topic><topic>miniature swine</topic><topic>Multiomic analysis</topic><topic>oleic acid</topic><topic>people</topic><topic>Persicaria capitata</topic><topic>Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross</topic><topic>proteomics</topic><topic>RNA</topic><topic>Streptozotocin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Yanjun</creatorcontrib><creatorcontrib>Mo, Jiayuan</creatorcontrib><creatorcontrib>Liang, Jing</creatorcontrib><creatorcontrib>Pu, Xiang</creatorcontrib><creatorcontrib>Dong, Yuanqiu</creatorcontrib><creatorcontrib>Zhu, Xiang</creatorcontrib><creatorcontrib>Zhao, Hai</creatorcontrib><creatorcontrib>Qiu, Huaming</creatorcontrib><creatorcontrib>Wu, Shuguang</creatorcontrib><creatorcontrib>Lu, Taofeng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Phytomedicine (Stuttgart)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Yanjun</au><au>Mo, Jiayuan</au><au>Liang, Jing</au><au>Pu, Xiang</au><au>Dong, Yuanqiu</au><au>Zhu, Xiang</au><au>Zhao, Hai</au><au>Qiu, Huaming</au><au>Wu, Shuguang</au><au>Lu, Taofeng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs</atitle><jtitle>Phytomedicine (Stuttgart)</jtitle><addtitle>Phytomedicine</addtitle><date>2024-06-01</date><risdate>2024</risdate><volume>128</volume><spage>155499</spage><epage>155499</epage><pages>155499-155499</pages><artnum>155499</artnum><issn>0944-7113</issn><eissn>1618-095X</eissn><abstract>•Multiomic study of the protective mechanism of P. capitata in streptozotocin-treated DN pig.
Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross (P. capitata, PCB), a traditional drug of the Miao people in China, is potential traditional drug used for the treatment of diabetic nephropathy (DN).
The purpose of this study is to investigate the function of P. capitata and clarify its protective mechanism against DN.
We induced DN in the Guizhou miniature pig with injections of streptozotocin, and P. capitata was added to the pigs’ diet to treat DN. In week 16, all the animals were slaughtered, samples were collected, and the relative DN indices were measured. 16S rRNA sequencing, metagenomics, metabolomics, RNA sequencing, and proteomics were used to explore the protective mechanism of P. capitata against DN.
Dietary supplementation with P. capitata significantly reduced the extent of the disease, not only in term of the relative disease indices but also in hematoxylin-eosin-stained tissues. A multiomic analysis showed that two microbes (Clostridium baratii and Escherichia coli), five metabolites (oleic acid, linoleic acid, 4-phenylbutyric acid, 18-β-glycyrrhetinic acid, and ergosterol peroxide), four proteins (ENTPD5, EPHX1, ARVCF and TREH), four important mRNAs (encoding ENTPD5, EPHX1, ARVCF, and TREH), six lncRNAs (TCONS_00024194, TCONS_00085825, TCONS_00006937, TCONS_00070981, TCONS_00074099, and TCONS_00097913), and two circRNAs (novel_circ_0001514 and novel_circ_0017507) are all involved in the protective mechanism of P. capitata against DN.
Our results provide multidimensional theoretical support for the study and application of P. capitata.
[Display omitted]</abstract><cop>Germany</cop><pub>Elsevier GmbH</pub><pmid>38492367</pmid><doi>10.1016/j.phymed.2024.155499</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-1550-5135</orcidid><orcidid>https://orcid.org/0000-0001-5881-905X</orcidid><orcidid>https://orcid.org/0000-0002-4379-8230</orcidid></addata></record> |
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| source | Elsevier ScienceDirect Journals |
| subjects | China Clostridium baratii Diabetic nephropathy dietary supplements drugs ergosterol Escherichia coli Guizhou miniature pig linoleic acid metabolites metabolomics metagenomics miniature swine Multiomic analysis oleic acid people Persicaria capitata Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross proteomics RNA Streptozotocin |
| title | Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs |
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