Therapeutic potential of salvigenin to combat atrazine induced liver toxicity in rats via regulating Nrf-2/Keap-1 and NF-κB pathway

Atrazine (ATR) is the second most extensively used herbicide which adversely affects the body organs including liver. Salvigenin (SGN) is a flavonoid which demonstrates a wide range of biological and pharmacological abilities. This study was planned to assess the protective ability of SGN to avert A...

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Veröffentlicht in:	Pesticide biochemistry and physiology 2024-06, Vol.202, p.105966, Article 105966
Hauptverfasser:	Edwards, Henry, Javed, Khadija, Yadev, Kumar, Ara, Chaman, Omer, Al-Mahmoud
Format:	Artikel
Sprache:	eng
Schlagworte:	albumins Animals Atrazine Atrazine - toxicity caspase-3 catalase Chemical and Drug Induced Liver Injury - drug therapy Chemical and Drug Induced Liver Injury - metabolism flavonoids glutathione peroxidase glutathione-disulfide reductase hepatotoxicity Herbicides - toxicity histology Inflammation interleukin-6 Isoflavones - pharmacology Kelch-Like ECH-Associated Protein 1 - metabolism liver Liver - drug effects Liver - metabolism Liver - pathology Liver damage Male malondialdehyde necrosis neoplasms NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism Oxidative stress Oxidative Stress - drug effects physiology poisoning prostaglandin synthase Rats Rattus norvegicus reactive oxygen species Reactive Oxygen Species - metabolism Salvigenin Signal Transduction - drug effects therapeutics Toxicity
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