Mapping novel QTL and fine mapping of previously identified QTL associated with glucose tolerance using the collaborative cross mice

A chronic metabolic illness, type 2 diabetes (T2D) is a polygenic and multifactorial complicated disease. With an estimated 463 million persons aged 20 to 79 having diabetes, the number is expected to rise to 700 million by 2045, creating a significant worldwide health burden. Polygenic variants of...

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Veröffentlicht in:	Mammalian genome 2024-03, Vol.35 (1), p.31-55
Hauptverfasser:	Abu-Toamih-Atamni, Hanifa J., Lone, Iqbal M., Binenbaum, Ilona, Mott, Richard, Pilalis, Eleftherios, Chatziioannou, Aristotelis, Iraqi, Fuad A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Genetics and Genomics Biomedical and Life Sciences blood glucose Blood levels Cell Biology Collaboration computer software Diabetes Diabetes mellitus (non-insulin dependent) environmental exposure Gene mapping Genetic markers genome Genomics Glucose Glucose tolerance glucose tolerance tests glycemic effect Haplotypes High fat diet Human Genetics Life Sciences loci Metabolic syndrome Metabolism mice noninsulin-dependent diabetes mellitus Phenotypes Polygenic inheritance Quantitative trait loci quantitative traits
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