Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study
Background Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This condition often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Given these considerations, the present study aims to elucidate the roles of social...
Gespeichert in:
| Veröffentlicht in: | The Journal of nutrition, health & aging health & aging, 2023-10, Vol.27 (10), p.797-805 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 805 |
|---|---|
| container_issue | 10 |
| container_start_page | 797 |
| container_title | The Journal of nutrition, health & aging |
| container_volume | 27 |
| creator | Lin, H.-Y. Lin, Y.-C. Chen, Liang-Kung Hsiao, Fei-Yuan |
| description | Background
Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This condition often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Given these considerations, the present study aims to elucidate the roles of social isolation in older adults with anorexia of aging and/or sarcopenia with respect to long-term mortality using a nationally representative cohort study.
Methods
Data were obtained from the Taiwan Longitudinal Study on Aging (TLSA), with a sample size of 3,762 study participants aged 50 years and older. Data from 1999 (wave 4) to 2015 (wave 9) were analyzed. The TLSA questionnaire was used to define social isolation, anorexia, and sarcopenia. Logistic regressions were employed to explore the associations between social isolation, anorexia, and sarcopenia. The Cox proportional hazard model was utilized to examine the synergistic effects of social isolation and anorexia or sarcopenia on 16-year all-cause mortality.
Results
After controlling for demographic information and comorbidities, older adults with social isolation were significantly associated with anorexia (adjusted odds ratio [aOR] 1.46 [95% confidence interval: 1.00–2.12, p=0.0475]) and sarcopenia (aOR 1.35 [95% CI: 1.12–1.64, p=0.0021]). Furthermore, the synergistic effects of social isolation with anorexia (aOR 1.65 [95% CI: 1.25–2.18, p=0.0004]) or sarcopenia (aOR 1.65 [95% CI: 1.42–1.92, p |
| doi_str_mv | 10.1007/s12603-023-1993-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3153609596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2889791500</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3991-ef936cec1503cb60e4372e0aa80912476b2207c03fc55831c5243ec6140f27ff3</originalsourceid><addsrcrecordid>eNqFkc1u1DAUhSMEoqXwAGyQJTYsGri2EztmV434GWkQi6HryOO5SV0ldrAdtdny5HiUAhISYuUj-bvHP19RvKTwlgLId5EyAbwExkuqFC-XR8U5lQLKSjbN45yZVKWUIM-KZzHeAlS1asTT4oxLJUABPS9-XLukXT9Y15N0g2Tjx2nAe7J1CcM06IUcMN0hOrL3xuqBbKMfdLLeXZIr5wPeW31J9joYP6E7Ze2O5IsPSQ82Le9zUbT9TYqkC34kmuy8622aj9blsn0Oy_PiSaeHiC8e1ovi-uOHb5vP5e7rp-3malcarhQtsVNcGDS0Bm4OArDikiFo3YCirJLiwBhIA7wzdd1wampWcTSCVtAx2XX8oniz9k7Bf58xpna00eAwaId-ji2nNc-_UivxX5Q1jVJKVOyEvv4LvfVzyI9bKanyfSFTdKVM8DEG7Nop2FGHpaXQnly2q8s2u2xPLtslz7x6aJ4PIx5_T_ySlwG2AjFvuR7Dn6P_3foTCoypxg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2889791500</pqid></control><display><type>article</type><title>Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study</title><source>MEDLINE</source><source>SpringerLink Journals</source><source>Alma/SFX Local Collection</source><creator>Lin, H.-Y. ; Lin, Y.-C. ; Chen, Liang-Kung ; Hsiao, Fei-Yuan</creator><creatorcontrib>Lin, H.-Y. ; Lin, Y.-C. ; Chen, Liang-Kung ; Hsiao, Fei-Yuan</creatorcontrib><description>Background
Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This condition often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Given these considerations, the present study aims to elucidate the roles of social isolation in older adults with anorexia of aging and/or sarcopenia with respect to long-term mortality using a nationally representative cohort study.
Methods
Data were obtained from the Taiwan Longitudinal Study on Aging (TLSA), with a sample size of 3,762 study participants aged 50 years and older. Data from 1999 (wave 4) to 2015 (wave 9) were analyzed. The TLSA questionnaire was used to define social isolation, anorexia, and sarcopenia. Logistic regressions were employed to explore the associations between social isolation, anorexia, and sarcopenia. The Cox proportional hazard model was utilized to examine the synergistic effects of social isolation and anorexia or sarcopenia on 16-year all-cause mortality.
Results
After controlling for demographic information and comorbidities, older adults with social isolation were significantly associated with anorexia (adjusted odds ratio [aOR] 1.46 [95% confidence interval: 1.00–2.12, p=0.0475]) and sarcopenia (aOR 1.35 [95% CI: 1.12–1.64, p=0.0021]). Furthermore, the synergistic effects of social isolation with anorexia (aOR 1.65 [95% CI: 1.25–2.18, p=0.0004]) or sarcopenia (aOR 1.65 [95% CI: 1.42–1.92, p<0.0001]) were both significantly associated with higher risks of all-cause mortality, while social isolation alone revealed borderline statistical significance.
Conclusions
Our findings indicate that social isolation is closely linked to anorexia and sarcopenia among middle-aged and older adults. Additionally, social isolation significantly exacerbates the long-term mortality risk associated with anorexia of aging and sarcopenia. However, social isolation alone appears to have borderline long-term mortality risk in this cohort. These findings underscore the importance of addressing social isolation in older adults with anorexia and/or sarcopenia to optimize their health outcomes and mitigate long-term mortality risk.</description><identifier>ISSN: 1279-7707</identifier><identifier>EISSN: 1760-4788</identifier><identifier>DOI: 10.1007/s12603-023-1993-y</identifier><identifier>PMID: 37960901</identifier><language>eng</language><publisher>Paris: Springer Paris</publisher><subject>Aged ; Aging ; Anorexia ; Anorexia - etiology ; Cohort Studies ; confidence interval ; Geriatric Assessment - methods ; Geriatrics/Gerontology ; Humans ; Longitudinal Studies ; Medicine & Public Health ; Middle Aged ; Mortality ; Neurosciences ; Nutrition ; odds ratio ; Older people ; Original Research ; Primary Care Medicine ; Quality of Life Research ; questionnaires ; risk ; sample size ; Sarcopenia ; Social Isolation ; Taiwan</subject><ispartof>The Journal of nutrition, health & aging, 2023-10, Vol.27 (10), p.797-805</ispartof><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2023</rights><rights>Serdi and Springer-Verlag International SAS, part of Springer Nature 2023.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3991-ef936cec1503cb60e4372e0aa80912476b2207c03fc55831c5243ec6140f27ff3</citedby><cites>FETCH-LOGICAL-c3991-ef936cec1503cb60e4372e0aa80912476b2207c03fc55831c5243ec6140f27ff3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12603-023-1993-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12603-023-1993-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37960901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, H.-Y.</creatorcontrib><creatorcontrib>Lin, Y.-C.</creatorcontrib><creatorcontrib>Chen, Liang-Kung</creatorcontrib><creatorcontrib>Hsiao, Fei-Yuan</creatorcontrib><title>Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study</title><title>The Journal of nutrition, health & aging</title><addtitle>J Nutr Health Aging</addtitle><addtitle>J Nutr Health Aging</addtitle><description>Background
Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This condition often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Given these considerations, the present study aims to elucidate the roles of social isolation in older adults with anorexia of aging and/or sarcopenia with respect to long-term mortality using a nationally representative cohort study.
Methods
Data were obtained from the Taiwan Longitudinal Study on Aging (TLSA), with a sample size of 3,762 study participants aged 50 years and older. Data from 1999 (wave 4) to 2015 (wave 9) were analyzed. The TLSA questionnaire was used to define social isolation, anorexia, and sarcopenia. Logistic regressions were employed to explore the associations between social isolation, anorexia, and sarcopenia. The Cox proportional hazard model was utilized to examine the synergistic effects of social isolation and anorexia or sarcopenia on 16-year all-cause mortality.
Results
After controlling for demographic information and comorbidities, older adults with social isolation were significantly associated with anorexia (adjusted odds ratio [aOR] 1.46 [95% confidence interval: 1.00–2.12, p=0.0475]) and sarcopenia (aOR 1.35 [95% CI: 1.12–1.64, p=0.0021]). Furthermore, the synergistic effects of social isolation with anorexia (aOR 1.65 [95% CI: 1.25–2.18, p=0.0004]) or sarcopenia (aOR 1.65 [95% CI: 1.42–1.92, p<0.0001]) were both significantly associated with higher risks of all-cause mortality, while social isolation alone revealed borderline statistical significance.
Conclusions
Our findings indicate that social isolation is closely linked to anorexia and sarcopenia among middle-aged and older adults. Additionally, social isolation significantly exacerbates the long-term mortality risk associated with anorexia of aging and sarcopenia. However, social isolation alone appears to have borderline long-term mortality risk in this cohort. These findings underscore the importance of addressing social isolation in older adults with anorexia and/or sarcopenia to optimize their health outcomes and mitigate long-term mortality risk.</description><subject>Aged</subject><subject>Aging</subject><subject>Anorexia</subject><subject>Anorexia - etiology</subject><subject>Cohort Studies</subject><subject>confidence interval</subject><subject>Geriatric Assessment - methods</subject><subject>Geriatrics/Gerontology</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neurosciences</subject><subject>Nutrition</subject><subject>odds ratio</subject><subject>Older people</subject><subject>Original Research</subject><subject>Primary Care Medicine</subject><subject>Quality of Life Research</subject><subject>questionnaires</subject><subject>risk</subject><subject>sample size</subject><subject>Sarcopenia</subject><subject>Social Isolation</subject><subject>Taiwan</subject><issn>1279-7707</issn><issn>1760-4788</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkc1u1DAUhSMEoqXwAGyQJTYsGri2EztmV434GWkQi6HryOO5SV0ldrAdtdny5HiUAhISYuUj-bvHP19RvKTwlgLId5EyAbwExkuqFC-XR8U5lQLKSjbN45yZVKWUIM-KZzHeAlS1asTT4oxLJUABPS9-XLukXT9Y15N0g2Tjx2nAe7J1CcM06IUcMN0hOrL3xuqBbKMfdLLeXZIr5wPeW31J9joYP6E7Ze2O5IsPSQ82Le9zUbT9TYqkC34kmuy8622aj9blsn0Oy_PiSaeHiC8e1ovi-uOHb5vP5e7rp-3malcarhQtsVNcGDS0Bm4OArDikiFo3YCirJLiwBhIA7wzdd1wampWcTSCVtAx2XX8oniz9k7Bf58xpna00eAwaId-ji2nNc-_UivxX5Q1jVJKVOyEvv4LvfVzyI9bKanyfSFTdKVM8DEG7Nop2FGHpaXQnly2q8s2u2xPLtslz7x6aJ4PIx5_T_ySlwG2AjFvuR7Dn6P_3foTCoypxg</recordid><startdate>20231001</startdate><enddate>20231001</enddate><creator>Lin, H.-Y.</creator><creator>Lin, Y.-C.</creator><creator>Chen, Liang-Kung</creator><creator>Hsiao, Fei-Yuan</creator><general>Springer Paris</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20231001</creationdate><title>Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study</title><author>Lin, H.-Y. ; Lin, Y.-C. ; Chen, Liang-Kung ; Hsiao, Fei-Yuan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3991-ef936cec1503cb60e4372e0aa80912476b2207c03fc55831c5243ec6140f27ff3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Aged</topic><topic>Aging</topic><topic>Anorexia</topic><topic>Anorexia - etiology</topic><topic>Cohort Studies</topic><topic>confidence interval</topic><topic>Geriatric Assessment - methods</topic><topic>Geriatrics/Gerontology</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neurosciences</topic><topic>Nutrition</topic><topic>odds ratio</topic><topic>Older people</topic><topic>Original Research</topic><topic>Primary Care Medicine</topic><topic>Quality of Life Research</topic><topic>questionnaires</topic><topic>risk</topic><topic>sample size</topic><topic>Sarcopenia</topic><topic>Social Isolation</topic><topic>Taiwan</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, H.-Y.</creatorcontrib><creatorcontrib>Lin, Y.-C.</creatorcontrib><creatorcontrib>Chen, Liang-Kung</creatorcontrib><creatorcontrib>Hsiao, Fei-Yuan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Psychology Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>The Journal of nutrition, health & aging</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, H.-Y.</au><au>Lin, Y.-C.</au><au>Chen, Liang-Kung</au><au>Hsiao, Fei-Yuan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study</atitle><jtitle>The Journal of nutrition, health & aging</jtitle><stitle>J Nutr Health Aging</stitle><addtitle>J Nutr Health Aging</addtitle><date>2023-10-01</date><risdate>2023</risdate><volume>27</volume><issue>10</issue><spage>797</spage><epage>805</epage><pages>797-805</pages><issn>1279-7707</issn><eissn>1760-4788</eissn><abstract>Background
Social isolation is a pervasive and debilitating condition that has adverse prognostic impacts. This condition often co-occurs with other geriatric syndromes, further exacerbating negative health outcomes. Given these considerations, the present study aims to elucidate the roles of social isolation in older adults with anorexia of aging and/or sarcopenia with respect to long-term mortality using a nationally representative cohort study.
Methods
Data were obtained from the Taiwan Longitudinal Study on Aging (TLSA), with a sample size of 3,762 study participants aged 50 years and older. Data from 1999 (wave 4) to 2015 (wave 9) were analyzed. The TLSA questionnaire was used to define social isolation, anorexia, and sarcopenia. Logistic regressions were employed to explore the associations between social isolation, anorexia, and sarcopenia. The Cox proportional hazard model was utilized to examine the synergistic effects of social isolation and anorexia or sarcopenia on 16-year all-cause mortality.
Results
After controlling for demographic information and comorbidities, older adults with social isolation were significantly associated with anorexia (adjusted odds ratio [aOR] 1.46 [95% confidence interval: 1.00–2.12, p=0.0475]) and sarcopenia (aOR 1.35 [95% CI: 1.12–1.64, p=0.0021]). Furthermore, the synergistic effects of social isolation with anorexia (aOR 1.65 [95% CI: 1.25–2.18, p=0.0004]) or sarcopenia (aOR 1.65 [95% CI: 1.42–1.92, p<0.0001]) were both significantly associated with higher risks of all-cause mortality, while social isolation alone revealed borderline statistical significance.
Conclusions
Our findings indicate that social isolation is closely linked to anorexia and sarcopenia among middle-aged and older adults. Additionally, social isolation significantly exacerbates the long-term mortality risk associated with anorexia of aging and sarcopenia. However, social isolation alone appears to have borderline long-term mortality risk in this cohort. These findings underscore the importance of addressing social isolation in older adults with anorexia and/or sarcopenia to optimize their health outcomes and mitigate long-term mortality risk.</abstract><cop>Paris</cop><pub>Springer Paris</pub><pmid>37960901</pmid><doi>10.1007/s12603-023-1993-y</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1279-7707 |
| ispartof | The Journal of nutrition, health & aging, 2023-10, Vol.27 (10), p.797-805 |
| issn | 1279-7707 1760-4788 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3153609596 |
| source | MEDLINE; SpringerLink Journals; Alma/SFX Local Collection |
| subjects | Aged Aging Anorexia Anorexia - etiology Cohort Studies confidence interval Geriatric Assessment - methods Geriatrics/Gerontology Humans Longitudinal Studies Medicine & Public Health Middle Aged Mortality Neurosciences Nutrition odds ratio Older people Original Research Primary Care Medicine Quality of Life Research questionnaires risk sample size Sarcopenia Social Isolation Taiwan |
| title | Untangling the Complex Interplay between Social Isolation, Anorexia, Sarcopenia, and Mortality: Insights from a Longitudinal Study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-05T03%3A24%3A33IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Untangling%20the%20Complex%20Interplay%20between%20Social%20Isolation,%20Anorexia,%20Sarcopenia,%20and%20Mortality:%20Insights%20from%20a%20Longitudinal%20Study&rft.jtitle=The%20Journal%20of%20nutrition,%20health%20&%20aging&rft.au=Lin,%20H.-Y.&rft.date=2023-10-01&rft.volume=27&rft.issue=10&rft.spage=797&rft.epage=805&rft.pages=797-805&rft.issn=1279-7707&rft.eissn=1760-4788&rft_id=info:doi/10.1007/s12603-023-1993-y&rft_dat=%3Cproquest_cross%3E2889791500%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2889791500&rft_id=info:pmid/37960901&rfr_iscdi=true |