Iridium-Catalyzed Ortho-Selective C–H Borylation of Aryl Ketones with Transient Imine Ligands

Iridium-Catalyzed Ortho-Selective C–H Borylation of Aryl Ketones with Transient Imine Ligands

Ortho-selective C–H borylation of aromatic ketones has not been extensively explored. Herein, we report the iridium-catalyzed ortho-selective C–H borylation of aromatic ketones using in situ-formed imine as the ligand. Good compatibility is observed for various substituted acetophenones and other ar...

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Veröffentlicht in:Organic letters 2024-05, Vol.26 (20), p.4224-4228
Hauptverfasser: Liang, Min, Liu, Chuangchuang, Ju, Wenjie, Han, Shuxiong, Zhang, Jingyu, Zhao, Yingsheng
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acetophenones
imines
ligands
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container_end_page 4228
container_issue 20
container_start_page 4224
container_title Organic letters
container_volume 26
creator Liang, Min
Liu, Chuangchuang
Ju, Wenjie
Han, Shuxiong
Zhang, Jingyu
Zhao, Yingsheng
description Ortho-selective C–H borylation of aromatic ketones has not been extensively explored. Herein, we report the iridium-catalyzed ortho-selective C–H borylation of aromatic ketones using in situ-formed imine as the ligand. Good compatibility is observed for various substituted acetophenones and other aromatic ketones, and corresponding products are obtained with medium to excellent yields.
doi_str_mv 10.1021/acs.orglett.4c01067
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subjects acetophenones
imines
ligands
title Iridium-Catalyzed Ortho-Selective C–H Borylation of Aryl Ketones with Transient Imine Ligands
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