Deciphering the therapeutic potential of SheXiangXinTongNing: Interplay between gut microbiota and brain metabolomics in a CUMS mice model, with a focus on tryptophan metabolism

•XTN demonstrates significant antidepressant effects in a CUMS mice model.•Network pharmacology reveals antidepressant action through modulation of key pathways, including IL-17 and dopamine signaling.•XTN mitigates depression symptoms by inhibiting neuroinflammation and pyroptosis.•Metabolomics hig...

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Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-07, Vol.129, p.155584-155584, Article 155584
Hauptverfasser:	Wang, Xiaohong, Zhou, Jiawei, Jiang, Tianlin, Xu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	16 S rRNA sequencing Animals antidepressants Antidepressive Agents - pharmacology behavior disorders brain Brain - drug effects Brain - metabolism calcium Chronic unpredictable mild stress Clostridia Cognition coronary disease Depression - drug therapy Depression - metabolism Disease Models, Animal domain dopamine Drugs, Chinese Herbal - pharmacology Gastrointestinal Microbiome - drug effects Helicobacter interleukin-17 intestinal microorganisms linoleic acid Male metabolism metabolites Metabolomics Mice Mice, Inbred C57BL Network Pharmacology Neuroinflammation Oriental traditional medicine pharmacology public health pyroptosis risk RNA, Ribosomal, 16S SheXiangXinTongNing species diversity Stress, Psychological - drug therapy synapse therapeutics tryptophan Tryptophan - metabolism
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