Baohuoside I suppresses the NLRP3 inflammasome activation via targeting GPER to fight against Parkinson's disease

Accumulating evidence indicates the crucial role of microglia-mediated inflammation and the NLR family pyrin domain containing 3 (NLRP3) inflammasome-mediated pyroptosis in the pathogenesis of Parkinson's disease (PD). Baohuoside I, a natural flavonoid extracted from Herba Epimedii, has been sh...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-04, Vol.126, p.155435-155435, Article 155435
Hauptverfasser:	Gu, Yu, Hu, Zi-Fan, Zheng, Dan-Wen, Yang, Yan-Qing, Dong, Xiao-Li, Chen, Wen-Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antagonists Anti-Inflammatory Agents - metabolism Anti-Inflammatory Agents - pharmacology astrocytes Baohuoside I Caspases - metabolism cytokines domain drugs energy estrogen receptors family flavonoids Flavonoids - pharmacology fluorescent antibody technique G protein-coupled estrogen receptor gene deletion gene targeting Icariside II immunohistochemistry Inflammasomes inflammation intragastric administration Lipopolysaccharides - pharmacology Mice Mice, Inbred C57BL Microglia Molecular Docking Simulation Neuroinflammatory Diseases Neuroprotective Agents - pharmacology NF-kappa B - metabolism NLR Family, Pyrin Domain-Containing 3 Protein - metabolism NLRP3 inflammasome Parkinson disease Parkinson Disease - drug therapy Parkinson Disease - metabolism Parkinson's disease pathogenesis pyroptosis quantitative polymerase chain reaction Receptors, G-Protein-Coupled - metabolism Western blotting
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!