Mechanic evaluation of Wu-Mei-Pill on colitis-associated colorectal cancer: An integrated transcriptomics, metabolomics, and experimental validation study

•Wu-Mei pill (WMP) inhibited tumor progression in CAC mice.•WMP activated the PPAR signaling pathway.•WMP inhibited Wnt signaling pathway-mediated EMT.•WMP limited the inflammatory response and inhibited the CCL3/CCR1 axis. Chronic intestinal inflammatory diseases play a crucial role in the onset of...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-06, Vol.128, p.155509-155509, Article 155509
Hauptverfasser:	Cui, Huantian, Jin, Yutong, Wang, Ning, Liu, Haizhao, Shu, Rongli, Wang, Jida, Wang, Xiangling, Jia, Beitian, Wang, Yiyang, Bian, Yuhong, Wen, Weibo
Format:	Artikel
Sprache:	eng
Schlagworte:	acyl-CoA dehydrogenase Animals Azoxymethane beta oxidation body weight changes cadherins carcinogenesis carnitine carnitine palmitoyltransferase CCL3/CCR1-mediated inflammatory responses CCR1 receptor chemokines Colitis - chemically induced Colitis-associated colorectal cancer Colitis-Associated Neoplasms colon Colon - drug effects Colon - metabolism Colon - pathology Colorectal Neoplasms dextran Dextran Sulfate Disease Models, Animal Drugs, Chinese Herbal - pharmacology fluorescent antibody technique interleukin-17 interleukin-6 ligands Male metabolites Metabolomics Mice Mice, Inbred C57BL Non-targeted metabolomics peroxisome proliferator-activated receptor alpha peroxisome proliferator-activated receptor gamma PPARα-mediated fatty acid oxidation sodium sulfate survival rate T-lymphocytes therapeutics transcription (genetics) Transcriptome Transcriptomics vimentin Western blotting wnt proteins Wnt signaling pathway-mediated epithelial-to-mesenchymal transition Wu-Mei-Pill
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!