Correlation of Gut Microbiota with Children Obesity and Weight Loss
Children obesity is a serious public health problem drawing much attention around the world. Recent research indicated that gut microbiota plays a vital role in children obesity, and disturbed gut microbiota is a prominent characteristic of obese children. Diet and exercise are efficient interventio...
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| Veröffentlicht in: | Indian journal of microbiology 2024-03, Vol.64 (1), p.82-91 |
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| creator | Peng, Li-Jun Chen, Yan-Ping Qu, Fang Zhong, Yan Jiang, Zhi-Sheng |
| description | Children obesity is a serious public health problem drawing much attention around the world. Recent research indicated that gut microbiota plays a vital role in children obesity, and disturbed gut microbiota is a prominent characteristic of obese children. Diet and exercise are efficient intervention for weight loss in obesity children, however, how the gut microbiota is modulated which remains largely unknown. To characterize the feature of gut microbiota in obese children and explore the effect of dietary and exercise on gut microbiota in simple obese children, 107 healthy children and 86 obese children were recruited, and among of the obese children 39 received the dietary-exercise combined weight loss intervention (DEI). The gut microbiota composition was detected by the 16S amplicon sequencing method. The gut microbiota composition was significantly different between obese children and the healthy cohort, and DEI significantly reduced the body weight and ameliorated the gut microbiota dysbiosis. After DEI, the abundance of the
Akkermansia muciniphila
was increased, while the abundance of the
Sutterella
genus was decreased in simple obese children. Our results may provide theoretical reference for future personalized obesity interventions based on gut microbiota. |
| doi_str_mv | 10.1007/s12088-023-01088-3 |
| format | Article |
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Akkermansia muciniphila
was increased, while the abundance of the
Sutterella
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Akkermansia muciniphila
was increased, while the abundance of the
Sutterella
genus was decreased in simple obese children. Our results may provide theoretical reference for future personalized obesity interventions based on gut microbiota.</description><subject>Abundance</subject><subject>Biomedical and Life Sciences</subject><subject>Body weight</subject><subject>Body weight loss</subject><subject>Children</subject><subject>Composition</subject><subject>diet</subject><subject>Dysbacteriosis</subject><subject>dysbiosis</subject><subject>exercise</subject><subject>genus</subject><subject>Health care</subject><subject>Intestinal microflora</subject><subject>intestinal microorganisms</subject><subject>Life Sciences</subject><subject>Medical Microbiology</subject><subject>Microbiology</subject><subject>Microbiota</subject><subject>Microorganisms</subject><subject>Obesity</subject><subject>Original Research Article</subject><subject>Public health</subject><subject>Sutterella</subject><subject>Weight control</subject><subject>Weight loss</subject><issn>0046-8991</issn><issn>0973-7715</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNqFkctLxDAQxoMo7rr6D3iQgBcv1cmjTXKU4gtWvCgeQx9TN9Jt1qRF_O_tuj7Ag57mg_nNN8x8hBwyOGUA6iwyDlonwEUCbK3EFpmCUSJRiqXbowaZJdoYNiF7MT4DpJnJ0l0yEVpmWgk-JXnuQ8C26J3vqG_o1dDTW1cFXzrfF_TV9QuaL1xbB-zoXYnR9W-06Gr6iO5p0dO5j3Gf7DRFG_Hgs87Iw-XFfX6dzO-ubvLzeVJJ0H1SlmhEA1wz4E2mS97UBjhTSsmqkg1yVBWglICm1oYZzSRTDCqORkuhjJiRk43vKviXAWNvly5W2LZFh36IVrBUpNqA_B_lJs1YBoqnI3r8C332Q-jGQ9aUlEpDujbkG2p8TYwBG7sKblmEN8vArtOwmzTsmIb9SMOKcejo03ool1h_j3y9fwTEBohjq3vC8LP7D9t3kmSR5Q</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Peng, Li-Jun</creator><creator>Chen, Yan-Ping</creator><creator>Qu, Fang</creator><creator>Zhong, Yan</creator><creator>Jiang, Zhi-Sheng</creator><general>Springer India</general><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope></search><sort><creationdate>20240301</creationdate><title>Correlation of Gut Microbiota with Children Obesity and Weight Loss</title><author>Peng, Li-Jun ; Chen, Yan-Ping ; Qu, Fang ; Zhong, Yan ; Jiang, Zhi-Sheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-bbe93f028102f68b2fd90217774cc4fe2e7c0e440e9d89198141710c2e9843793</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abundance</topic><topic>Biomedical and Life Sciences</topic><topic>Body weight</topic><topic>Body weight loss</topic><topic>Children</topic><topic>Composition</topic><topic>diet</topic><topic>Dysbacteriosis</topic><topic>dysbiosis</topic><topic>exercise</topic><topic>genus</topic><topic>Health care</topic><topic>Intestinal microflora</topic><topic>intestinal microorganisms</topic><topic>Life Sciences</topic><topic>Medical Microbiology</topic><topic>Microbiology</topic><topic>Microbiota</topic><topic>Microorganisms</topic><topic>Obesity</topic><topic>Original Research Article</topic><topic>Public health</topic><topic>Sutterella</topic><topic>Weight control</topic><topic>Weight loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peng, Li-Jun</creatorcontrib><creatorcontrib>Chen, Yan-Ping</creatorcontrib><creatorcontrib>Qu, Fang</creatorcontrib><creatorcontrib>Zhong, Yan</creatorcontrib><creatorcontrib>Jiang, Zhi-Sheng</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><jtitle>Indian journal of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peng, Li-Jun</au><au>Chen, Yan-Ping</au><au>Qu, Fang</au><au>Zhong, Yan</au><au>Jiang, Zhi-Sheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of Gut Microbiota with Children Obesity and Weight Loss</atitle><jtitle>Indian journal of microbiology</jtitle><stitle>Indian J Microbiol</stitle><addtitle>Indian J Microbiol</addtitle><date>2024-03-01</date><risdate>2024</risdate><volume>64</volume><issue>1</issue><spage>82</spage><epage>91</epage><pages>82-91</pages><issn>0046-8991</issn><eissn>0973-7715</eissn><abstract>Children obesity is a serious public health problem drawing much attention around the world. Recent research indicated that gut microbiota plays a vital role in children obesity, and disturbed gut microbiota is a prominent characteristic of obese children. Diet and exercise are efficient intervention for weight loss in obesity children, however, how the gut microbiota is modulated which remains largely unknown. To characterize the feature of gut microbiota in obese children and explore the effect of dietary and exercise on gut microbiota in simple obese children, 107 healthy children and 86 obese children were recruited, and among of the obese children 39 received the dietary-exercise combined weight loss intervention (DEI). The gut microbiota composition was detected by the 16S amplicon sequencing method. The gut microbiota composition was significantly different between obese children and the healthy cohort, and DEI significantly reduced the body weight and ameliorated the gut microbiota dysbiosis. After DEI, the abundance of the
Akkermansia muciniphila
was increased, while the abundance of the
Sutterella
genus was decreased in simple obese children. Our results may provide theoretical reference for future personalized obesity interventions based on gut microbiota.</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>38468732</pmid><doi>10.1007/s12088-023-01088-3</doi><tpages>10</tpages></addata></record> |
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| subjects | Abundance Biomedical and Life Sciences Body weight Body weight loss Children Composition diet Dysbacteriosis dysbiosis exercise genus Health care Intestinal microflora intestinal microorganisms Life Sciences Medical Microbiology Microbiology Microbiota Microorganisms Obesity Original Research Article Public health Sutterella Weight control Weight loss |
| title | Correlation of Gut Microbiota with Children Obesity and Weight Loss |
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