Structure, cooperativity and inhibition of the inosine 5′‐monophosphate‐specific phosphatase from Saccharomyces cerevisiae

The nucleoside inosine is a main intermediate of purine nucleotide catabolism in Saccharomyces cerevisiae and is produced via the dephosphorylation of inosine monophosphate (IMP) by IMP‐specific 5′‐nucleotidase 1 (ISN1), which is present in many eukaryotic organisms. Upon transition of yeast from ox...

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Veröffentlicht in:	The FEBS journal 2024-05, Vol.291 (9), p.1992-2008
Hauptverfasser:	Byun, Sujeong, Park, Changkon, Suh, Jeong‐Yong, Witte, Claus‐Peter, Rhee, Sangkee
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites Adenosine triphosphate Allosteric properties allosteric site ATP Catabolism Dephosphorylation Homeostasis inosine Inosine monophosphate negative regulation Nucleotidase Nucleotides Plasmodium falciparum purine metabolism Saccharomyces cerevisiae Yeast Yeasts
Online-Zugang:	Volltext
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