Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta‐analysis of randomized controlled trials
The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta‐analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta‐analysis of h...
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| Veröffentlicht in: | Phytotherapy research 2024-05, Vol.38 (5), p.2560-2571 |
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| creator | Shylaja, Hanumanthappa Viswanatha, Gollapalle Lakshminarayanashastry Sunil, Venkategowda Hussain, Shalam M. Farhana, Syeda Ayesha |
| description | The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta‐analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta‐analysis of hesperidin to determine its beneficial effect in alleviating alterations in cardiovascular parameters. In this study, the literature search was performed using online databases such as PubMed and Google Scholar till April 2023 involving randomized controlled studies conducted on hesperidin against various cardiovascular disorders including metabolic disorders in healthy/diseased individuals compared to the placebo/control. Based on the inclusion and exclusion criteria, nine clinical studies involving 2414 subjects were included. The meta‐analysis revealed that hesperidin has significantly reduced the low‐density lipoprotein (LDL) (IV: −0.55 (−0.94 to −0.16) at 95% CI, p = 0.005, I2 = 70%), total cholesterol (TC) (IV: −61 (−0.82 to −0.41) at 95% CI, p |
| doi_str_mv | 10.1002/ptr.8174 |
| format | Article |
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Also, there is a meta‐analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta‐analysis of hesperidin to determine its beneficial effect in alleviating alterations in cardiovascular parameters. In this study, the literature search was performed using online databases such as PubMed and Google Scholar till April 2023 involving randomized controlled studies conducted on hesperidin against various cardiovascular disorders including metabolic disorders in healthy/diseased individuals compared to the placebo/control. Based on the inclusion and exclusion criteria, nine clinical studies involving 2414 subjects were included. The meta‐analysis revealed that hesperidin has significantly reduced the low‐density lipoprotein (LDL) (IV: −0.55 (−0.94 to −0.16) at 95% CI, p = 0.005, I2 = 70%), total cholesterol (TC) (IV: −61 (−0.82 to −0.41) at 95% CI, p < 0.00001, I2 = 69%), and triglycerides (TG) (IV: −0.21 (−0.40 to −0.02) at 95% CI, p = 0.03, I2 = 12%). However, there were no statistically significant changes in the systolic blood pressure (IV: −0.29 (−2.21 to 1.63) at 95% CI, p = 0.77, I2 = 60%), diastolic blood pressure (IV: 0.79 (−0.74 to 2.31) at 95% CI, p = 0.31, I2 = 49%), and high‐density lipoprotein (IV: 0.04 (−0.25 to 0.34) at 95% CI, p = 0.78, I2 = 56%) in the hesperidin treatment compared to the placebo/control. In conclusion, the outcomes of this meta‐analysis suggest that hesperidin administration could benefit patients with CVD by reducing LDL, TC, and TG. Further high‐quality studies are needed to firmly establish the clinical efficacy of hesperidin for its benefits in treating cardiovascular conditions.</description><identifier>ISSN: 0951-418X</identifier><identifier>ISSN: 1099-1573</identifier><identifier>EISSN: 1099-1573</identifier><identifier>DOI: 10.1002/ptr.8174</identifier><identifier>PMID: 38462779</identifier><language>eng</language><publisher>Chichester, UK: John Wiley & Sons, Ltd</publisher><subject>Blood pressure ; Blood Pressure - drug effects ; cardioprotective effect ; cardiovascular disease ; Cardiovascular Diseases - prevention & control ; Cholesterol ; clinical studies ; Clinical trials ; Density ; diastolic blood pressure ; Hesperidin ; Hesperidin - pharmacology ; high density lipoprotein ; Humans ; lipid composition ; lipid profile ; Lipids ; Lipids - blood ; Low density lipoprotein ; Meta-analysis ; Metabolic disorders ; myocardial infarction ; phytotherapy ; Placebos ; Randomized Controlled Trials as Topic ; Statistical analysis ; Systematic review ; systolic blood pressure ; Triglycerides ; Triglycerides - blood</subject><ispartof>Phytotherapy research, 2024-05, Vol.38 (5), p.2560-2571</ispartof><rights>2024 John Wiley & Sons Ltd.</rights><rights>2024 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3434-7747a2d553624861a6bd1bbc32361804736965e8baa9c56b901e941dc1aa75783</cites><orcidid>0009-0009-9368-2672 ; 0000-0002-9944-4888</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fptr.8174$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fptr.8174$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38462779$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shylaja, Hanumanthappa</creatorcontrib><creatorcontrib>Viswanatha, Gollapalle Lakshminarayanashastry</creatorcontrib><creatorcontrib>Sunil, Venkategowda</creatorcontrib><creatorcontrib>Hussain, Shalam M.</creatorcontrib><creatorcontrib>Farhana, Syeda Ayesha</creatorcontrib><title>Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta‐analysis of randomized controlled trials</title><title>Phytotherapy research</title><addtitle>Phytother Res</addtitle><description>The cardioprotective activity of hesperidin has been well demonstrated in several clinical studies. Also, there is a meta‐analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta‐analysis of hesperidin to determine its beneficial effect in alleviating alterations in cardiovascular parameters. In this study, the literature search was performed using online databases such as PubMed and Google Scholar till April 2023 involving randomized controlled studies conducted on hesperidin against various cardiovascular disorders including metabolic disorders in healthy/diseased individuals compared to the placebo/control. Based on the inclusion and exclusion criteria, nine clinical studies involving 2414 subjects were included. The meta‐analysis revealed that hesperidin has significantly reduced the low‐density lipoprotein (LDL) (IV: −0.55 (−0.94 to −0.16) at 95% CI, p = 0.005, I2 = 70%), total cholesterol (TC) (IV: −61 (−0.82 to −0.41) at 95% CI, p < 0.00001, I2 = 69%), and triglycerides (TG) (IV: −0.21 (−0.40 to −0.02) at 95% CI, p = 0.03, I2 = 12%). However, there were no statistically significant changes in the systolic blood pressure (IV: −0.29 (−2.21 to 1.63) at 95% CI, p = 0.77, I2 = 60%), diastolic blood pressure (IV: 0.79 (−0.74 to 2.31) at 95% CI, p = 0.31, I2 = 49%), and high‐density lipoprotein (IV: 0.04 (−0.25 to 0.34) at 95% CI, p = 0.78, I2 = 56%) in the hesperidin treatment compared to the placebo/control. In conclusion, the outcomes of this meta‐analysis suggest that hesperidin administration could benefit patients with CVD by reducing LDL, TC, and TG. Further high‐quality studies are needed to firmly establish the clinical efficacy of hesperidin for its benefits in treating cardiovascular conditions.</description><subject>Blood pressure</subject><subject>Blood Pressure - drug effects</subject><subject>cardioprotective effect</subject><subject>cardiovascular disease</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cholesterol</subject><subject>clinical studies</subject><subject>Clinical trials</subject><subject>Density</subject><subject>diastolic blood pressure</subject><subject>Hesperidin</subject><subject>Hesperidin - pharmacology</subject><subject>high density lipoprotein</subject><subject>Humans</subject><subject>lipid composition</subject><subject>lipid profile</subject><subject>Lipids</subject><subject>Lipids - blood</subject><subject>Low density lipoprotein</subject><subject>Meta-analysis</subject><subject>Metabolic disorders</subject><subject>myocardial infarction</subject><subject>phytotherapy</subject><subject>Placebos</subject><subject>Randomized Controlled Trials as Topic</subject><subject>Statistical analysis</subject><subject>Systematic review</subject><subject>systolic blood pressure</subject><subject>Triglycerides</subject><subject>Triglycerides - blood</subject><issn>0951-418X</issn><issn>1099-1573</issn><issn>1099-1573</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkctqFUEQQBsxmGsU_AJpcONmkn4_3IUQHxCISAR3Q09PDXbomR67ZxKuK_0Dv9EvsW8eCoK4qqI4HCgOQs8oOaSEsKN5yYeGavEAbSixtqFS84doQ6ykjaDm0z56XMolIcQyIh6hfW6EYlrbDfp-OgzgF5wG_BnKDDn0YcJpwl1MqcdzhlLWDNhNPY5hDrtTGkKEV_gYl21ZYHRL8DjDVYDrG2yExf389sNNLm5LKDt1rvc0hq_QY5-mJacY67rk4GJ5gvaGOuDp3TxAH1-fXpy8bc7O37w7OT5rPBdcNFoL7VgvJVdMGEWd6nradZ4zrqghQnNllQTTOWe9VJ0lFKygvafOaakNP0Avb731gS8rlKUdQ_EQo5sgraXlVHKpmdH8vyizUjJljBAVffEXepnWXF-vQiKJIYwb-0focyolw9DOOYwub1tK2l3BthZsdwUr-vxOuHYj9L_B-2QVaG6B61ph-09R-_7iw43wF_UjpcQ</recordid><startdate>202405</startdate><enddate>202405</enddate><creator>Shylaja, Hanumanthappa</creator><creator>Viswanatha, Gollapalle Lakshminarayanashastry</creator><creator>Sunil, Venkategowda</creator><creator>Hussain, Shalam M.</creator><creator>Farhana, Syeda Ayesha</creator><general>John Wiley & Sons, Ltd</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7QP</scope><scope>7QR</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0009-0009-9368-2672</orcidid><orcidid>https://orcid.org/0000-0002-9944-4888</orcidid></search><sort><creationdate>202405</creationdate><title>Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta‐analysis of randomized controlled trials</title><author>Shylaja, Hanumanthappa ; 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Also, there is a meta‐analysis published on this topic in 2019. However, considering the recently published clinical studies, there is a scope for performing a systematic review and meta‐analysis of hesperidin to determine its beneficial effect in alleviating alterations in cardiovascular parameters. In this study, the literature search was performed using online databases such as PubMed and Google Scholar till April 2023 involving randomized controlled studies conducted on hesperidin against various cardiovascular disorders including metabolic disorders in healthy/diseased individuals compared to the placebo/control. Based on the inclusion and exclusion criteria, nine clinical studies involving 2414 subjects were included. The meta‐analysis revealed that hesperidin has significantly reduced the low‐density lipoprotein (LDL) (IV: −0.55 (−0.94 to −0.16) at 95% CI, p = 0.005, I2 = 70%), total cholesterol (TC) (IV: −61 (−0.82 to −0.41) at 95% CI, p < 0.00001, I2 = 69%), and triglycerides (TG) (IV: −0.21 (−0.40 to −0.02) at 95% CI, p = 0.03, I2 = 12%). However, there were no statistically significant changes in the systolic blood pressure (IV: −0.29 (−2.21 to 1.63) at 95% CI, p = 0.77, I2 = 60%), diastolic blood pressure (IV: 0.79 (−0.74 to 2.31) at 95% CI, p = 0.31, I2 = 49%), and high‐density lipoprotein (IV: 0.04 (−0.25 to 0.34) at 95% CI, p = 0.78, I2 = 56%) in the hesperidin treatment compared to the placebo/control. In conclusion, the outcomes of this meta‐analysis suggest that hesperidin administration could benefit patients with CVD by reducing LDL, TC, and TG. Further high‐quality studies are needed to firmly establish the clinical efficacy of hesperidin for its benefits in treating cardiovascular conditions.</abstract><cop>Chichester, UK</cop><pub>John Wiley & Sons, Ltd</pub><pmid>38462779</pmid><doi>10.1002/ptr.8174</doi><tpages>12</tpages><orcidid>https://orcid.org/0009-0009-9368-2672</orcidid><orcidid>https://orcid.org/0000-0002-9944-4888</orcidid></addata></record> |
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| subjects | Blood pressure Blood Pressure - drug effects cardioprotective effect cardiovascular disease Cardiovascular Diseases - prevention & control Cholesterol clinical studies Clinical trials Density diastolic blood pressure Hesperidin Hesperidin - pharmacology high density lipoprotein Humans lipid composition lipid profile Lipids Lipids - blood Low density lipoprotein Meta-analysis Metabolic disorders myocardial infarction phytotherapy Placebos Randomized Controlled Trials as Topic Statistical analysis Systematic review systolic blood pressure Triglycerides Triglycerides - blood |
| title | Effect of hesperidin on blood pressure and lipid profile: A systematic review and meta‐analysis of randomized controlled trials |
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