Structural Characterization of a Pathogenic Antibody Underlying Vaccine-Induced Immune Thrombotic Thrombocytopenia (VITT)

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare but dangerous side effect of adenoviral-vectored COVID-19 vaccines. VITT had been linked to production of autoantibodies recognizing platelet factor 4 (PF4). Here, we characterize anti-PF4 antibodies obtained from a VITT patient’s b...

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Veröffentlicht in:	Analytical chemistry (Washington) 2024-04, Vol.96 (16), p.6209-6217
Hauptverfasser:	Nguyen, Son N., Le, Si-Hung, Ivanov, Daniil G., Ivetic, Nikola, Nazy, Ishac, Kaltashov, Igor A.
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Amino acid sequence amino acid sequences Amino acids analytical chemistry Antibodies Autoantibodies Blood case studies chemokine CXCL4 COVID-19 infection COVID-19 vaccines Fragments germ cells Glycan Glycosylation Immunoglobulin G Monoclonal antibodies mutation patients Peptide mapping Peptides Platelet factor 4 proteinases Segments Sequence analysis Structural analysis Thrombocytopenia Vaccines
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