Effects of trastuzumab emtansine on canine urothelial carcinoma cells in vitro and in vivo

Urothelial carcinoma (UC) is the most common malignancy of the urinary tract in dogs and has aggressive behaviour. Although human epidermal growth factor receptor 2 (HER2) is a known therapeutic target with evidence in canine UC, the efficacy of anti‐HER2 antibody drugs remains unknown. This study a...

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Veröffentlicht in:	Veterinary & comparative oncology 2024-06, Vol.22 (2), p.230-238
Hauptverfasser:	Sakai, Kosei, Kato, Daiki, Yoshinaka, Junka, Takahashi, Yosuke, Ikeda, Namiko, Aoki, Susumu, Iguchi, Takaaki, Ishikawa, Shingo, Yamagishi, Norio, Shimamura, Shunsuke, Nakagawa, Takayuki
Format:	Artikel
Sprache:	eng
Schlagworte:	aggression antibodies apoptosis carcinoma cell cycle cell lines dog dogs dose response erbB-2 receptor flow cytometry HER2 protein synthesis therapeutics trastuzumab T‐DM1 urinary tract urothelial carcinoma
Online-Zugang:	Volltext
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