The role of miR-433-3p in vascular calcification in type 2 diabetic patients: targeting WNT/β-Catenin and RANKL/RANK/OPG signaling pathways

Background Vascular calcification (VC) is a major predictor of cardiovascular diseases that represent the principal cause of mortality among type-2 diabetic patients. Accumulating data suggest the vital role of some microRNAs on vascular calcification as an epigenetic regulator. Thus, we assessed he...

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Veröffentlicht in:	Molecular biology reports 2023-11, Vol.50 (11), p.9073-9083
Hauptverfasser:	Elshamy, Amira M., Hafez, Yasser Mostafa, Safa, Mohamed A. E., Ibrahim, Hoda A., Khalfallah, Mohamed, Rizk, Fatma H., Eltabaa, Eman F., Ghafar, Muhammad T. Abdel, Atef, Marwa Mohamed
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal Anatomy Animal Biochemistry beta Catenin - genetics beta Catenin - metabolism Biomedical and Life Sciences blood serum Calcification Calcification (ectopic) Cardiovascular diseases Cbfa-1 protein Chromosome 3 Core Binding Factor Alpha 1 Subunit - genetics Diabetes Diabetes mellitus Diabetes Mellitus, Type 2 - complications Diabetes Mellitus, Type 2 - genetics Dkk1 protein Down-regulation Epigenetics Gene expression Histology Humans Life Sciences ligands microRNA MicroRNAs - genetics MicroRNAs - metabolism miRNA Morphology mortality noninsulin-dependent diabetes mellitus Original Article Osteoprotegerin Osteoprotegerin - genetics Osteoprotegerin - metabolism Signal transduction Signal Transduction - genetics TRANCE protein Vascular Calcification - genetics Vascular Calcification - metabolism Wnt protein β-Catenin
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