An enzymic l-2-hydroxyglutarate biosensor based on l-2-hydroxyglutarate dehydrogenase from Azoarcus olearius

l-2-Hydroxyglutarate (l-2-HG) is a critical signaling and immune metabolite but its excessive accumulation can lead to l-2-hydroxyglutaric aciduria, renal cancer, and other diseases. Development of efficient and high-throughput methods for selective l-2-HG detection is urgently required. In this stu...

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Veröffentlicht in:	Biosensors & bioelectronics 2024-01, Vol.243, p.115740-115740, Article 115740
Hauptverfasser:	Hou, Shuang, Kang, Zhaoqi, Liu, Yidong, Lü, Chuanjuan, Wang, Xia, Wang, Qian, Ma, Cuiqing, Xu, Ping, Gao, Chao
Format:	Artikel
Sprache:	eng
Schlagworte:	Azoarcus Biosensor biosensors dehydrogenation detection limit fluorescence Fluorescent assay humans kidney neoplasms l-2-Hydroxyglutarate l-2-Hydroxyglutarate dehydrogenase metabolites oxidoreductases Resazurin
Online-Zugang:	Volltext
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