Binding Evolution of the Dengue Virus Envelope Against DC-SIGN: A Combined Approach of Phylogenetics and Molecular Dynamics Analyses Over 30 Years of Dengue Virus in Brazil

[Display omitted] •The Red Queen Hypothesis in virus-host interactions; viruses adapt proteins, hosts alter receptors.•Mutual adaptation shapes receptor interactions, informing disease unpredictability and interventions.•The article utilizes phylogenetics, modeling, and dynamics, focusing on Brazili...

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Veröffentlicht in:	Journal of molecular biology 2024-06, Vol.436 (11), p.168577-168577, Article 168577
Hauptverfasser:	Penteado, André Berndt, de Oliveira Ribeiro, Geovani, Lima Araújo, Emerson Luiz, Kato, Rodrigo Bentes, de Melo Freire, Caio Cesar, de Araújo, Joselio Maria Galvão, da Luz Wallau, Gabriel, Salvato, Richard Steiner, de Jesus, Ronaldo, Bosco, Geraldine Goés, Franz, Helena Ferreira, da Silva, Pedro Eduardo Almeida, de Souza Leal, Elcio, Goulart Trossini, Gustavo Henrique, de Lima Neto, Daniel Ferreira
Format:	Artikel
Sprache:	eng
Schlagworte:	Brazil Cell Adhesion Molecules - chemistry Cell Adhesion Molecules - genetics Cell Adhesion Molecules - metabolism coevolution Dengue - virology dengue envelope protein Dengue virus Dengue Virus - genetics Dengue Virus - metabolism Evolution, Molecular Host-Pathogen Interactions - genetics Humans Lectins, C-Type - chemistry Lectins, C-Type - genetics Lectins, C-Type - metabolism ligands molecular biology molecular dynamics Molecular Dynamics Simulation Phylogeny Protein Binding Receptors, Cell Surface - chemistry Receptors, Cell Surface - genetics Receptors, Cell Surface - metabolism Receptors, Virus - chemistry Receptors, Virus - genetics Receptors, Virus - metabolism Red Queen Hypothesis therapeutics Viral Envelope - metabolism Viral Envelope Proteins - chemistry Viral Envelope Proteins - genetics Viral Envelope Proteins - metabolism viral evolution viral phylogeny viruses
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